97,465 papers found

Combination products are therapeutic and diagnostic products that combine drugs, devices and/or biological products, leading to safer and more effective treatments thanks to careful and precise drug targeting, local administration and individualized therapy. These technologies can especially benefit patients suffering…

OBJECTIVE: To describe 34 cases of placental site trophoblastic tumor (PSTT) treated at Charing Cross Hospital over 25 years. STUDY DESIGN: Between 1975 and 2001, 1,685 patients with gestational trophoblastic disease (GTD) were treated; 34 of them had PSTT (2%). The computer database clinical notes and the pathology r…

BACKGROUND: The aim of this study was to investigate the effect of reduction loss of more than 3 mm on clinical and radiological results after at least 2 years of follow-up after arthroscopic fixation of acute acromioclavicular joint dislocations using a double-button device. METHODS: Thirty-six patients…

Thirty-five years after their initial description, ramp lesions of the medial meniscus in anterior cruciate ligament (ACL)-deficient knees are slowly being rediscovered. Routinely repaired in open ACL and peripheral reconstructions before the era of arthroscopic ACL reconstruction, ramp lesions have been largely ignore…

The management of rheumatoid arthritis has changed dramatically over the last three decades. Improvements in clinical assessment have been a key driver of these changes. However, in the last five years, three areas of unresolved uncertainty have dominated specialist thinking in the field. These challenges comprise iden…

Pentannulated heterocycles are the key structural subunit of many natural and biologically active compounds. Over the last decades, many precious metal-assisted pentannulations have been described as a consequence of an extensive research. This Focus Review gives an overview of precious metal-catalyzed reactions applie…

The only method aiming to permanently cure allergic disorders is allergen immunotherapy. Over the last 20 years there has been great progress in understanding the mechanisms that govern allergen immunotherapy in order to meet three basic prerequisites: safety, effectiveness and compliance. In the present summary report…

The last years were characterized by efforts on the field of urological oncology: development of highly effective regimens for the curative treatment of metastatic diseases, improvement of diagnostic techniques based on monoclonal antibodies and molecularbiological techniques, development of operative techniques to imp…

Breast angiosarcomas are malignant tumours of the vascular endothelium that arise frequently following radiation therapy. Their clinical and radiological aspects are highly heterogeneous. The current study reports an unusual case, never previously reported, of a late recurrent breast angiosarcoma occurring in an 83-yea…

In 222 nonselected, otherwise healthy children, seven repetitive tympanometric screenings were performed from ages 4 to 7 years. At the last three screenings, otomicroscopy was performed and the changes of the eardrum were analyzed. At age five years 24%, at age six years 37%, and at age seven years 39% of all 444 ears…

AIM: The RM Classic® cup shows very good results. The RM Pressfit® cup has an equatorial pressfit; it is a monoblock implant without metalback. The aim of this study was to evaluate retrospectively the survival of this implant, monitoring patients for at least 5 years in all consecutive cases operated in our…

IMPORTANCE: Clinician specialization in the care of nursing home (NH) residents or patients in skilled nursing facilities (SNFs) has become increasingly common. It is not known whether clinicians focused on NH care, often referred to as SNFists (ie, physicians, nurse practitioners, and physician assistants concentratin…

Doxylamine succinate, one of the antihistamines available without a prescription for patients suffering from insomnia, is also an antihistamine with the potential for abuse. Although there are case reports about the addictive potential of antihistamines, there are not many studies on doxylamine succinate addiction in t…

Surfactant crystals can stabilize liquid foams. The crystals are adsorbed at bubble surfaces, slowing down coarsening and coalescence. Excess crystals in the liquid channels between bubbles arrest drainage, leading to ultrastable foams. The melting of crystals upon raising the temperature allows thermoresponsive foams…

Hip arthroscopy has evolved significantly over the last 5 to 10 years. With this comes the burden of patients with continued pain after their index procedure. Reasons for the need for revision surgery can be many, including incomplete resection of impingement morphology, unrecognized/unaddressed acetabular dysplasia or…

Deficient bone volume, anatomical limitations, lack of available mesiodistal space, adjacent teeth angulations, and surgical errors may lead to placement of narrow diameter implants. In such a scenario, functional and esthetic-yet sustainable-replacement of more than one missing tooth becomes quite challenging. This ar…

This study investigated the prevalence of inclusion body hepatitis (IBH) infections during the past five years (2010-2014) in broiler chicken flocks in Poland. The diagnosis of IBH was based on anatomopathological investigations and histopathological analyzes. IBH was the most prevalent disease in broiler flocks in Pol…

In medicine time is one of the main dimensions used in order to assess the efficacy of a cure. In oncology we measure either the advantage obtained with a treatment or the clinical course of a cancer as time intervals or survival benefit. In the last years we can describe life expectancy in many solid tumors following…

Heart failure (HF) represents the quintessential disorder of cardiovascular aging, reflecting the convergence of age-related changes in the cardiovascular system and other organ systems and the increasing prevalence of cardiovascular diseases at older age. The prevalence and incidence of HF increase progressively with…