392,269 papers found

BACKGROUND: Type 2 diabetes mellitus (T2DM) is a highly prevalent chronic metabolic disorder, and a substantial proportion of patients eventually require insulin therapy, which is frequently complicated by therapeutic inertia, hypoglycemia and glycemic variability. Automated insulin delivery (AID) systems combine conti…

INTRODUCTION: A proportion of patients hospitalised for COVID-19 acquire the disease during their hospital stay, underscoring the risk of hospital-acquired COVID-19 (HA-COVID-19). This risk is presumed to be high, given how commonly and intensely air and surfaces within hospitals are reportedly contaminated with SARS-C…

BACKGROUND: Wildfire, driven by climate change, continues to pose significant health, social, economic and environmental challenges in the twenty-first century. Although the association between wildfire smoke exposure and health outcomes has been studied, comprehensive systematic reviews and meta-analyses on the global…

INTRODUCTION: Postoperative pulmonary complications affect approximately 40% of individuals undergoing lung cancer surgery. A number of clinical trials and meta-analyses have shown that postoperative telehabilitation may reduce the incidence of postoperative adverse events while reducing transport time and outpatient c…

BACKGROUND: Despite the increasing clinical use of glucagon-like peptide-1 receptor agonists (GLP-1 RAs), head-to-head evidence across these agents remains limited. This systematic review and network meta-analysis (NMA) will assess the comparative efficacy and safety of GLP-1 RAs and novel co-agonists for weight loss a…

BACKGROUND: Amphetamine-type stimulant use disorder (ATSUD) contributes to the global burden of disease, notably due to its social, physical, and psychological consequences. Psychiatric disorders are frequently observed among people with ATSUD, while we still do not know their exact global prevalence because of multipl…

INTRODUCTION: Perioperative sleep disturbance (PSD) can adversely affect immunological and cognitive functions, can prolong hospital stays and have long-lasting effects on quality of life, ultimately increasing mortality rates. Unfortunately, PSD is common among surgical patients and can manifest at any stage during su…

OBJECTIVES: Assessing the certainty of evidence (COE) of both direct and indirect evidence of is crucial for enhancing the understanding of network meta-analysis (NMA) findings and drawing appropriate conclusions. To make the certainty rating of indirect evidence feasible, Grading of Recommendations Assessment, Develop…

BACKGROUND: The gut microbiota (GM) plays a critical role in systemic health, influencing immune, metabolic, and neurological functions. There is emerging evidence suggesting that moxibustion, a traditional thermal therapy, may modulate the GM to restore microbial homeostasis, yet its exclusive effects remain undiffere…

BACKGROUND: Consolidation of treatment effects from randomized controlled trials (RCT) is considered one of the highest forms of evidence in research. Cluster randomized trials (CRT) are increasingly used in the assessment of the effectiveness of interventions when individual-level randomization is impractical. In meta…

INTRODUCTION: Physical inactivity is a major global public health concern, increasing the risk factor of non-communicable diseases (NCDs) and mortality. The WHO has initiated the Global Action Plan on Physical Activity to reduce global physical inactivity by 15% by 2030. Rapid urbanisation and insufficient physical act…

INTRODUCTION: Cancer-related insomnia (CRI), a significant concurrent symptom of cancer, profoundly impacts patients. Non-pharmacological interventions include cognitive behavioural therapy, mindfulness-based stress reduction programmes, bright light, acupuncture, exercise and music therapies and tai chi. These approac…