11,611,577 papers found

Minor ginsenosides produced by β-glucosidase are interesting biologically and pharmacologically. In this study, new ginsenoside-hydrolyzing glycosidase from Furfurilactobacillus rossiae DCYL3 was cloned and expressed in Escherichia coli strain BL21. The enzyme converted Rb1 and Gyp XVII into Rd and compound K fol…

Tuberculosis (TB) is among diseases of global health importance with Sub Saharan Africa (SSA) accounting for 25% of the global TB burden. TB prevalence among miners in SSA is estimated at 3,000-7,000/100,000, which is about 3 to 10-times higher than in the general population. The study's objective was to determine the…

BACKGROUND: Nosocomial pneumonia ranks among the top 5 diseases that lead to additional financial costs due to hospitalization. This study aimed to evaluate the cost of oral care and its clinical effectiveness in preventing pneumonia in a systematic review. METHODS: The search was conducted in the following databases:…

BACKGROUND: Organ transplant recipients (OTRs) taking immunosuppressants are at high risk of skin cancer, which is the most common malignant condition in OTRs, so dermatologic surveillance is important for OTRs. OBJECTIVES: To characterize the most common skin cancers arising from chronic immunosuppression in OTRs. M…

Self-efficacy is a critical factor influencing quality of care, particularly for psychiatric nurses at higher occupational risk; however, research on its current status and influencing factors among the nursing population in China remains scarce. This study aimed to investigate the self-efficacy level of psychiatric nu…

Mutual support groups are increasingly implemented in higher education settings across high-income countries to promote peer-based support, with demonstrated benefits for emotional well-being and social connectedness. However, their impact on other domains of students' lives remains underexplored, particularly in low-…

BACKGROUND: This cross-sectional study aimed to quantify the impact of implant-related complications on perceived pain, functional impairment, concern, quality of life (QoL) and confidence which were the study's primary outcomes. MATERIALS AND METHODS: Patients were recruited in five centres over 19 months. The…

INTRODUCTION: The ICH E9 addendum outlining the estimand framework for clinical trials was published in 2019 but provides limited guidance around how to handle intercurrent events for non-inferiority studies. Once an estimand is defined, it is also unclear how to deal with missing values using principled analyses for n…

BACKGROUND: Being able to use COVID-19 RT-PCR Ct values as simple clinical markers of disease outcome or prognosis would allow for the easy and proactive identification and triaging of high-risk cases. This study's objective was thus to explore whether a correlation exists between COVID-19 viral loads, as indicate…

BACKGROUND: The physiologic assessment of anal sphincters in cases of posttraumatic fecal incontinence is a fundamental step in planning operative treatment. In this study, we evaluate the correlation between size of anal sphincter defect, anal pressures, and clinical symptoms in patients with posttraumatic fecal incon…

PURPOSE: The aim of this study was to test the feasibility and acceptability of an Information and Communication Technology platform for assessing and managing patient reported symptoms during radiotherapy for prostate cancer. METHODS: In cooperation with a health management company, using a patient experience co-desi…

BACKGROUND: Despite alarming increases in suicide deaths among preadolescent children, knowledge of the precipitants of suicide risk and the characteristics of children who seek treatment for suicidality is limited. This study's purpose is to describe children (ages 6-12) hospitalized for suicide-related concerns and c…

Atherosclerosis causes abnormal blood flow. Four-dimensional (4D) magnetic resonance imaging (MRI) is a recently developed technique that can be used to quantify abnormal blood flow. Several blood flow parameters may reflect thoracic aortic calcification (TAC). The aim of this study was to evaluate the relationship bet…

It is widely established that sensory perception is a rhythmic process as opposed to a continuous one. In the context of auditory perception, this effect is only established on a cortical and behavioral level. Yet, the unique architecture of the auditory sensory system allows its primary sensory cortex to modulate the…

BACKGROUND: This study investigated whether ChatGPT 4o could accurately estimate the difficulty of medical assessment items by comparing its predictions with empirically-derived parameters from multistage testing simulations. METHODS: Using a hybrid simulation-validation design, the researchers had ChatGPT 4o generate…

This study's objective was to verify whether improved social and emotional skills would reduce victimization among Brazilian 6th grade student victims of bullying. The targets of this intervention were victimized students; a total of 78 victims participated. A cognitive-behavioral intervention based on social and emoti…

Domestic dogs are skillful at using the human pointing gesture. In this study we investigated whether dogs take contextual information into account when following pointing gestures, specifically, whether they follow human pointing gestures more readily in the context in which food has been found previously. Also varied…

BACKGROUND: Ischemic stroke is a major cause of death and morbidity, and risk classification is essential for predicting therapeutic outcomes. MicroRNAs may be useful indicators for risk stratification, as they control gene expression and influence physiological and pathological processes. METHODOLOGY: A systematic st…

Cervical cancer ranks among the most prevalent cancers globally with high-risk human papillomaviruses implicated in nearly 99% of cases. However, hidden players such as changes in the microbiota are now being examined as potential markers in the progression of this disease. Researchers suggest that changes in the vagin…

E-commerce has the potential to address problems in the agricultural supply chain and support the implementation of rural revitalization strategies. Previous research has largely focused on the business models of rural e-commerce platforms, but has not examined the mechanisms by which they can optimize and reconfigure…