11,611,577 papers found

IMPORTANCE: Overweight and obesity in childhood and adolescence is a global health issue associated with adverse outcomes throughout the life course. OBJECTIVE: To estimate worldwide prevalence of overweight and obesity in children and adolescents from 2000 to 2023 and to assess potential risk factors for and comorbid…

Primary central nervous system lymphoma (PCNSL) is an aggressive and rare malignancy with poor prognosis. However, there are no reliable prognostic biomarkers for PCNSL in clinical practice. Here, we aimed to identify a reliable prognostic biomarker for predicting the survival of PCNSL patients. In this study, multiple…

BACKGROUND: Transparency and reproducibility are expected to be normative practices in clinical trials used for decision-making on marketing authorisations for new medicines. This registered report introduces a cross-sectional study aiming to assess inferential reproducibility for main trials assessed by the European M…

This study investigates student and teacher perceptions of using augmented reality (AR) in the classroom and evaluates AR's impact on student cognition and academic performance. Research on its use for educational purposes is at the cradle stage, requiring more investigations. To provide more insights into the efficacy…

The dental pattern allows a taxonomic assignment of a primate and some deductions about his food preference and survival behaviour. The purpose is to define the Hominid's diet and behaviour, through a dental study. The Australopithecines teeth pattern was human like and quite different from Pongid pattern. Author indic…

BACKGROUND AND OBJECTIVE: Delivering drugs to the deviated regions in patients with nasal septal deviation is vital for the treatment but challenging due to the complex shape of the nasal cavity and the intersubject variability in the nasal anatomies. While previous studies have focused on drug delivery to standard are…

Burns generate every year an important burden of morbidity, being a major global public health problem through prolonged hospitalization, complications, and increased mortality. This study's purpose was to evaluate the serum levels of three adipokines and to establish significant correlations with other circulating mol…

The molecular profile of neurotrophic tyrosine kinase receptor (NTRK) gene fusions in lung adenocarcinoma (LUAD) is not fully understood. Next-generation sequencing (NGS) and pan-tyrosine kinase receptor (TRK) immunohistochemistry (IHC) are powerful tools for NTRK fusion detection. In this study, a total of 4,619 LUAD…

The origins of the functional class I genes predated human speciation, a phenomenon known as trans-speciation. The retention of class Ia orthologues within the great apes, however, has not been paralleled by studies designed to examine the pseudogene content, organization, and structure of their class I regions. Theref…

INTRODUCTION: Prostate-specific antigen (PSA) is a key marker for prostate cancer screening, but its utility is debated, prompting exploration of PSA derivatives for improved accuracy. While racial variations in serum PSA levels are documented, limited data exists for the Indian population. Given increasing life expect…

This research study aimed to investigate the association between demographic and operational factors and emergency medical services (EMS) missions ending in non-conveyance (NC) due to patient-initiated refusal (PIR). We conducted a retrospective population-based registry study by analyzing 67,620 EMS missions dispatche…

Although there is now a substantial body of research suggesting a positive association between the exposure to sexualized content in the media and self-objectification/body surveillance, most of the studies have been cross-sectional, conducted in exclusively female samples, focused on the use of traditional media (e.g.…

AIMS: To describe the Great Smoky Mountains Study (GSMS). METHODS: GSMS is a longitudinal study of child psychiatric disorders that began in 1992 to look at need for mental health services in a rural area of the USA. Over 20 years it has expanded its range to include developmental epidemiology more generally, not only…

Chronic kidney disease (CKD) is a major burden on the healthcare system because of its increasing prevalence, high risk of progression to end-stage renal disease, and poor morbidity and mortality prognosis. It is rapidly becoming a global health crisis. Unhealthy dietary habits and insufficient water consumption are si…

Nurses in primary health care (PHC) have multiple responsibilities but must often work with limited resources. The study's aim was to estimate burnout levels among PHC nurses. A Quantitative, observational, cross-sectional, multicentre study of 338 nurses working in PHC in the Andalusian Public Health Service (Spain) i…

AIM: To elucidate the incidence of and risk factors for severe hypertensive disorders (HD) and related maternal complications in uncomplicated twin pregnancies that reached 36 weeks' gestation. METHODS: We conducted a prospective cohort study of twin pregnancies delivered after 36 weeks' gestation. Cases of twin-twin…

Relationship status influences mental and physical health in the general population and may mitigate radiological abnormalities in multiple sclerosis (MS). However, there are limited data about whether one's relationship status impacts the neurobehavioral symptoms of MS, such as depression, anxiety, fatigue, or self-re…

BACKGROUND: Many studies have shown some relationships between thermal perception (including thermal sensation and thermal comfort) and human physiological parameters, such as brain signals. However, further research is still needed on how these parameters can help recognize the state of a human's personal thermal perc…

OBJECTIVES: To characterize human-gingival-fibroblast-(HGFs) viability, proliferation and adhesion on polymer-infiltrated-ceramic-network-(PICN), polyetheretherketone-(PEEK), hydroxyapatite-reinforced-polyetheretherketone-(HA-PEEK), polyetherketoneketone-(PEKK), as well as conventional titanium-(Ti) and zirconia cerami…

With the advancement in reusable rocket propulsion technology, space tourist trips into outer space are now becoming a possibility at a cost-effective rate. As such, astronauts will face a host of health-related challenges, particularly on long-duration space missions where maintaining a balanced healthy microbiome is…