44,680 papers found

The vast majority of the available literature regarding cardiovascular oscillations refers to spontaneously breathing subjects. Only a few studies investigated cardiovascular oscillations, and especially respiration-related ones (RCVO), during intermittent positive pressure mechanical ventilation (IPPV) under anaesthes…

BACKGROUND: It is unclear whether or not untreated bounded edentulous spaces (BES) can cause patients problems because of migration of unopposed and adjacent teeth. OBJECTIVES: To quantitatively assess BES-related occlusal changes and the level of evidence available. MATERIAL AND METHODS: A systematic search of the l…

OBJECTIVE: To assess the benefits and harms of antenatal antithrombotic therapy for women at risk of adverse pregnancy outcomes associated with placental dysfunction. SEARCH STRATEGY: PUBMED and the Cochrane Controlled Trials Register (CENTRAL) were searched. Reference lists of retrieved studies were searched by hand.…

BACKGROUND: The clinical management of intermittent exotropia has been discussed frequently in the literature, but there is a lack of clarity regarding the indications for intervention, the most effective type and if there is a time point at which it should be carried out. OBJECTIVES: The objective of this review was…

BACKGROUND: The brainstem nucleus locus coeruleus (LC) is a rod-shaped, cylindrical, deeply pigmented neuromelanin (NM)-rich cluster of noradrenergic cells placed bilaterally in the dorsolateral tegmentum of the pons. The main neurotransmitter synthesised by these neurons is norepinephrine (NE), which polymerises to NM…

, known as the brain-eating amoeba, is a thermophilic, freshwater amoeba causing primary amoebic meningoencephalitis (PAM), a disease that progresses rapidly from symptom onset to death. Climate change is causing surface water temperatures to increase, providing a hospitable environment for, possibly increasing risk fa…

AIM: To estimate the pooled prevalence of cerebral palsy (CP) among children in South Asia. METHOD: A comprehensive search was conducted using electronic databases, including PubMed, Scopus, Cochrane Library, Wiley Online Library, SpringerLink, Web of Science, and the BMC Journal Collection (BioMed Central), up to Jun…

Infertility is an increasing concern for many women and can affect both physical and emotional well-being. The central nervous system (CNS) - particularly the hypothalamus, pituitary gland, and pineal gland - plays a crucial role in female reproductive health. We conducted a narrative review of relevant studies publish…

Hormonal influences on inner ear physiology are increasingly recognized, particularly in cochlear function; however, their role in vestibular physiology remains incompletely understood. Hormonal contraceptives represent a major source of exogenous hormonal exposure, yet their effects on vestibular function, symptom exp…

BACKGROUND: Occlusal dysesthesia (OD) is a debilitating condition characterized by persistent occlusal discomfort in the absence of detectable occlusal abnormalities. Despite decades of clinical recognition, OD remains poorly understood, frequently misdiagnosed and inconsistently managed. OBJECTIVE: To map the existin…

BACKGROUND: Periodontitis is a prevalent chronic inflammatory disease with recognized systemic implications. Its potential link to female reproductive disorders, including infertility, endometriosis, and recurrent implantation failure (RIF), has attracted growing attention, though the evidence remains heterogeneous and…

BACKGROUND: The neuropsychological effects of psychedelic compounds are well-documented; however, their respiratory activity is less clear. Since respiration is a physiologically significant process and psychedelics have increasingly attracted attention in therapies, assessing the potential effects on respiration is re…

Orexin-A and orexin-B, originally discovered as hypothalamic neuropeptides, have been detected in extra-hypothalamic tissues together with their receptors (OXR and OXR) since the early 2000s. This systematic review is the first to comprehensively synthesize evidence on the autocrine/paracrine effects of locally produce…

INTRODUCTION: Insomnia and hypertension frequently co-occur and may exacerbate cardiovascular risk. While acupuncture and related therapies (ARTs) are widely used for sleep symptoms, their comparative effectiveness across modalities remains unclear. This protocol outlines a Bayesian network meta-analysis (NMA) to compa…

BACKGROUND: Parkinson's disease (PD) is a multifactorial neurodegenerative disorder characterised by dopaminergic neuron loss and pathological accumulation of alpha-synuclein. Emerging evidence highlights a crucial interplay between mitochondrial dysfunction and disrupted lipid homeostasis as central mechanisms driving…

Inflammatory bowel diseases (IBDs) encompass Crohn's disease and ulcerative colitis. They represent idiopathic and chronic inflammatory conditions. Mucosal immune dysfunction and compromised gastrointestinal barrier integrity are implicated in the pathophysiological mechanisms of inflammatory bowel diseases. Recent stu…

INTRODUCTION: Teenage pregnancy is a significant global public health challenge with far-reaching consequences for young mothers, their children, families and society at large. Yet, the evidence synthesis landscape in teenage pregnancy prevention remains fragmented, with systematic reviews typically examining specific…

INTRODUCTION: In modern warfare, blast and burn insults account for over half of combat injuries. Burn-injured Service Members represent one military patient population in need of a pain management regimen that involves optimal acute pain control, reduced chronic pain, and reduced risk of addiction. Burn pain is a sign…

BACKGROUND: Tuberculous meningitis (TBM) is the most common central nervous system infection of(). The infection will cause focal neurological deficits and can be fatal, so that it will increase the morbidity and mortality rates. Adequate treatment is needed so that the drug can reach the center of infection. Not all a…

BACKGROUND: This systematic review and meta-analysis aimed to compare outcomes of 0.01% atropine with orthokeratology (AOK) vs. orthokeratology (OK) alone for slowing the progression of myopia in children. METHODS: MEDLINE via PubMed, Embase, Scopus, Web of Science, CENTRAL (Cochrane Central Register of Controlled Tri…