386,737 papers found

The prevalence of type 2 diabetes mellitus (T2DM) is increasing around the world. We hypothesized that time-restricted eating (TRE) could impact cardiometabolic factors and anthropometric indices in adults with T2DM. This umbrella review aimed to provide an accurate estimate of the overall effects of TRE on these indiv…

BACKGROUND AND AIMS: Accurate polyp measurement is vital for colorectal cancer treatment and surveillance. Traditional methods are often unreliable. The FDA-approved Virtual Scale Endoscopy (VSE) provides real-time, laser-calibrated overlays to improve size measurements. This meta-analysis evaluated the diagnostic accu…

OBJECTIVE: Gastrointestinal adverse effects are the most commonly reported adverse effects associated with the use of antidepressants. While existing studies on the gastrointestinal effects of antidepressant medications offer valuable insights, there are still opportunities to enhance the evidence base. METHODS: We in…

OBJECTIVE: To compare the efficacy and safety of lisdexamfetamine, topiramate, and naltrexone/bupropion for treating binge eating disorder (BED) using network meta-analysis. METHOD: We systematically searched PubMed, Scopus, ClinicalTrials.gov, and Cochrane Central up to February 2025 for randomized controlled trials…

BACKGROUND: The combination of neuromodulation interventions with robot-assisted gait training (RAGT) for enhancing lower limb motor function recovery in stroke patients remains contentious. OBJECTIVE: This study aims to investigate the effects of neuromodulation combined with RAGT on patients with lower limb motor dy…

PURPOSE: This systematic review aimed to evaluate the effect of the abutment material on peri-implant soft tissue health and stability. STUDY SELECTION: An electronic and hand search was conducted until February 2022. Only prospective randomized trials (RCTs) and controlled clinical trials (CCTs) comparing titanium ab…

OBJECTIVE: The aim of this study is to perform the first meta-meta-analysis on the effectiveness of parent-based interventions for children with externalizing behavior problems. Even though parent-based interventions are considered as effective treatments the effects reported in meta-analyses are heterogeneous and the…

The review aimed at quantifying the evidence of performance effects resulting from occupational exposure to manganese. Epidemiological studies published between 1987 and 2008 were analyzed. The approach was based on the meta-analytical method of effect size estimates and sought to contribute to the following issues: (1…

BACKGROUND: Genome-wide association studies hold substantial promise for identifying common genetic variants that regulate susceptibility to complex diseases. However, for the detection of small genetic effects, single studies may be underpowered. Power may be improved by combining genome-wide datasets with meta-analyt…

Establishing the overall efficacy or safety of a drug requires a unified methodological approach and analysis of all clinical trials to be included. As an example, this paper presents the aggregated dose-response relationship of efficacy data and a last-value analysis of laboratory data across all studies of the antihy…

Because individual studies evaluating the role of quinidine in the maintenance of sinus rhythm after cardioversion from chronic atrial fibrillation have involved relatively few patients, a meta-analysis of randomized control trials was performed. Six trials published between 1970 and 1984 were selected by two blinded r…

To estimate the comparative effectiveness of tailored exercise therapies in people with chronic, nonspecific low back pain.Systematic review with network meta-analysis.We searched PubMed, Cochrane Library, Web of Science, and Google Scholar from inception to August 27, 2024.Only randomized controlled trials (RCTs) stud…

BACKGROUND: The role of postoperative antithrombotic therapy in microvascular free flap reconstruction remains controversial, with no consensus on the optimal regimen. METHODS: A systematic review and arm-based Bayesian network meta-analysis was conducted searching PubMed, Scopus, and Google Scholar databases. Aspirin…

OBJECTIVES: The objective of this study was to evaluate video-assisted dispatcher cardiopulmonary resuscitation (V-DACPR) versus audio-assisted dispatcher CPR impacts on compression quality in simulated out-of-hospital cardiac arrest (OHCA) scenarios. METHODS: Network meta-analysis of randomized controlled trials (RCT…

OBJECTIVES: A systematic review and network meta-analysis were conducted to address the following research question: "What is the most effective preventive treatment for reducing the risk of jaw osteonecrosis after tooth extraction in patients receiving medications associated with osteonecrosis?" MATERIAL AND METHODS:…

BACKGROUND: Parkinson's disease is a progressive neurodegenerative disorder that causes significant motor function limitations, substantially impacting the quality of life of affected individuals and their caregivers. While the currently available pharmacological therapy with levodopa can alleviate symptoms, identifyin…

OBJECTIVE: In this study we conducted a meta-analysis of 13 case-control studies that examined the occurrence of hematopoietic cancers in pesticide related occupations in order to undertake a qualitative and quantitative evaluation of a possible relationship. METHODS: Pubmed databases were searched for case-control st…

OBJECTIVE: To obtain a quantitative estimate of the impact on infectious complications of using transparent dressings with intravenous catheters. DATA SOURCES: Meta-analysis of all studies published in the English literature, including abstracts, letters, and reports that examined the primary research question of infe…

OBJECTIVE: This network meta-analysis (NMA) of randomized controlled trials (RCTs) evaluates the long-term efficacy and feasibility of treatments for macular edema (ME) secondary to retinal vein occlusion (RVO). Comparisons between different alternatives remain unclear. METHODS: We used a Bayesian framework to perform…

Hepatocellular carcinoma (HCC) is one of the leading causes of cancer-associated death globally. Second-line therapies are crucial for improving survival and quality of life among individuals suffering from advanced HCC who have not responded to first-line therapies. This study sought to evaluate the safety and efficac…