376,015 papers found

Two recently published meta-analyses of controlled trials of a wide variety of progestational agents, used in pregnancy (Daya 1989; Goldstein et al. 1989), prompted this third meta-analysis of placebo-controlled trials involving the prophylactic use of a single agent, 17 alpha-hydroxyprogesterone caproate. Of seven rel…

Thrombolytic therapy has become an established procedure in patients with acute myocardial infarction (AMI). However, the aftercare of such patients is still uncertain. A meta-analysis of twenty trials of intravenous or subcutaneous heparin in AMI performed during the prethrombolysis period indicated a significant redu…

Results of numerous independent studies suggest that families of a critically ill hospitalized member have similar needs that they can readily identify as very important. Empirical analysis of results compiled from many studies across patient populations, settings, geographic locations, and over time indicates that fam…

This review of the literature focuses on risk factors of smoking, hypertension, obesity, and family history that are associated with the development of coronary heart disease. The prevalence of these cardiac risk factors are incorporated from several Canadian health surveys. Health professionals in cardiovascular setti…

BACKGROUND: Levosimendan is an inodilator developed for treatment of acute heart failure and other cardiac conditions where the use of an inodilator is considered appropriate. Levosimendan has been studied in different therapeutic settings including acutely decompensated chronic heart failure, advanced heart failure, r…

The primary objective of this study is to evaluate the efficacy of various pharmaceuticals (combination therapy versus monotherapy) in patients with glioblastoma (GB) with abnormal epidermal growth factor receptor (EGFR) genes. Clinical trials to investigate the therapeutic effects of different therapy was searched by…

BACKGROUND AND OBJECTIVE: Mind-body exercise (MBE) has emerged as a vital adjunctive modality in the rehabilitation of chronic heart failure (CHF). However, the relative advantages of various MBE types in improving functional capacity and quality of life (QoL) remain elusively defined. This study aimed to compare the t…

BACKGROUND: Chronic low back pain (CLBP) is often accompanied by anxiety and depression, which hinders clinical treatment. Therefore, this study conducts a Bayesian network meta-analysis to compare the effectiveness of different non-drug interventions in relieving pain and related emotional symptoms in CLBP patients.…

BACKGROUND: Tumor necrosis factor-α inhibitors (TNFi) are established to increase the risk of tuberculosis (TB). However, the comparative risk across different TNFi agents remains poorly defined due to a lack of head-to-head comparative studies. This network meta-analysis (NMA) aimed to evaluate and compare the r…

BackgroundVaricose vein surgery increases the risk of venous thromboembolism (VTE). Although pharmacological thromboprophylaxis is commonly used postoperatively, its efficacy and optimal regimen remain unclear. This study systematically reviews the effectiveness and safety of various anticoagulant strategies.MethodsA c…

BACKGROUND: Stroke is a leading cause of long-term disability worldwide, particularly among older adults, and severely compromises functional independence and quality of life. Exercise interventions are well established as effective strategies for promoting motor recovery through improvements in neuroplasticity, fitnes…

BACKGROUND AND OBJECTIVES: Red blood cell transfusions are commonly required in pediatric cranial vault remodeling (CVR); however, they carry risks and potential complications. This study evaluates the evidence on perioperative blood conservation agents assessing their efficacy in optimizing and reducing transfusion re…

The plasma concentration versus antihypertensive effect relationship for the calcium antagonist felodipine was investigated in 67 patients with hypertension and 21 healthy subjects by use of the Emax model. No consistent effect of felodipine on blood pressure was observed in the healthy subjects. In patients with hyper…

This paper reports findings of a subset of 91 programs, which included drug use measures, from the data base previously reported in the author's meta-analysis of 143 adolescent drug prevention programs. Treatment components of strategies successful in decreasing drug use by adolescents are discussed with regard to both…

Meta-analysis on data from 16 (two volunteer and 14 endoscopic) studies ahs been performed to investigate the prevalence of Helicobacter pylori infection in the stomachs of individuals within the Peoples Republic of China. In this survey covering 2216 cases (89 volunteers and 2127 endoscopy patients), the incidence of…

With transcranial direct-current stimulation's (tDCS) popularity both in motor learning research and as a commercial product, it is important that the quality of evidence on its effectiveness be evaluated. Special attention should be paid to meta-analyses, as they usually have a large impact on research and clinical pr…

Tissue factor pathway inhibitor (TFPI) impedes early stages of the blood coagulation response, and low TFPI plasma levels increase the risk of thrombosis. TFPI plasma levels are heritable, but specific genetic determinants are unclear. We conducted a comprehensive review of genetic risk factors for TFPI plasma levels a…

Diagnostic test accuracy studies assess a diagnostic test's performance against a reference standard. In this review, we explore and compare statistical methods used in meta-analyses of diagnostic test accuracy studies. Specifically, we evaluate two frequentist methods - split component synthesis (SCS) and bivariate mo…

BACKGROUND: Pressure sores, also known as pressure ulcers, present a critical health-care challenge, with a prevalence of 5%-20% in Western countries and annual costs exceeding $26.8 billion in the US. This study evaluates the effectiveness of various dressings in preventing pressure ulcers, aiming to improve patient c…