44,680 papers found

BACKGROUND AND AIMS: Lower extremity amputation (LEA) is a commonly performed surgery and is associated with significant mortality and morbidity. This review compares the impact of anaesthetic technique on 30-day mortality and other perioperative outcomes in patients undergoing LEA. METHODS: A systematic search of dat…

BACKGROUND: Nonoperative treatment with functional rehabilitation of Achilles tendon ruptures (ATRs) has become more common because of claim of "equivalent" risk of rerupture compared to operative treatment. We investigated how current evidence corroborates the often-claimed "equal" or "nondifferent" complication rates…

BACKGROUND: Idiopathic membranous nephropathy (IMN) is one of the leading causes of nephrotic syndrome in adults. We performed a protocol for systematic review and meta-analysis to compare the efficacy and safety of cyclophosphamide (CTX) with calcineurin inhibitors (CNIs) in the treatment of IMN. METHODS: PubMed, EMB…

BACKGROUND: Previous clinical studies have reported that electrical stimulation (ES) can be utilized to treat children with limbs spasticity (LS) after traumatic brain injury (TBI). Currently, no systematic review has addressed the effect of ES in children with LS following TBI. Thus, this systematic review will assess…

OBJECTIVE: The efficacy of add-on use of spironolactone in patients with resistant hypertension has been investigated in several small studies. We performed this meta-analysis evaluating the efficacy of add-on use of spironolactone in these patients. METHODS: We searched Pubmed, Web of Science, and Cochrane Central fo…

Diabetes is a major cause of morbidity for patients undergoing surgery and can increase the incidence of some postoperative complications such as bedsores. We conducted a meta-analysis of observational studies to examine whether patients with diabetes undergoing surgery had high risk of bedsore. We performed a systemat…

PURPOSE: To evaluate the efficacy and safety of bipolar and monopolar transurethral resection of bladder tumor (TURBT) procedures for non-muscle invasive bladder cancer (NMIBC) patients. MATERIALS AND METHODS: We searched for all studies investigating bipolar TURBT and monopolar TURBT for NMIBC patients in PubMed, Web…

AIM: The potential benefits and safety of early oral feeding (EOF) after cesarean section have not been well evaluated. We undertook a meta-analysis to assess postoperative bowel function and complications following EOF compared with delayed oral feeding (DOF) in women who had undergone cesarean section. METHODS: PubM…

PURPOSE: To evaluate the adverse events associated with tunneled central venous catheters (CVCs) and totally implantable venous access device (TIVAD) in patients of pediatric oncology undergoing chemotherapy. MATERIALS AND METHODS: A comprehensive search was retrospectively conducted using PubMed, Embase, Web of Scien…

BACKGROUND: Age-related macular degeneration (AMD) causes progressive and irreversible damage to the retina, resulting in loss of central vision. AMD is the third leading cause of irreversible visual impairment worldwide and the leading cause of blindness in industrialized countries. Since AMD is more common in older i…

Descemet membrane detachment (DMD) is an uncommon but clinically significant complication of cataract surgery, particularly phacoemulsification. This review summarizes current evidence on the incidence, risk factors, diagnosis, and management of DMD associated with cataract surgery. A narrative literature review identi…

PURPOSE: Adenosine monophosphate-activated protein kinase (AMPK) is a central regulator of cellular energy homeostasis that integrates metabolic stress signals arising from nutrient deprivation and other adverse conditions. Dysregulation of AMPK signaling is involved in malignancies, as cancer cells reprogram nutrient…

5a-reductase (5a-R) isozymes are essential for androgen metabolism and neurosteroid biosynthesis, linking endocrinology and neuropsychiatry. This systematic review, conducted in accordance with PRISMA 2020 guidelines, aimed to synthesize current evidence on the tissue distribution of SRD5A1, SRD5A2, and SRD5A3 and thei…

BACKGROUND: Individuals undergoing lung cancer surgery often face significant postoperative challenges, underscoring the importance of identifying effective preoperative rehabilitation strategies to support recovery. AIM: To identify rehabilitation interventions that can be implemented during the preoperative period f…

The PDBBind database has been widely utilized for the computational prediction of protein-protein binding affinities. While the accuracy of the PDBBind-curated equilibrium dissociation constants (KD) has been reported for the protein-ligand subset of the PDBBind database, the curation accuracy has not been reported for…

Myelin degeneration is a hallmark of multiple sclerosis, a chronic, autoimmune neurological condition that alters Central Nervous System communication. Despite the fact that the pathophysiology of multiple sclerosis is multifactorial and not fully understood, new research indicates that reducing oxidative stress and in…

The role of gut microecology in attention deficit hyperactivity disorder (ADHD) has garnered growing attention. Studies have suggested a potential link between ADHD development and an imbalance in gut microbiota composition. This review aims to analyze the characteristics of the gut microbiota in children with ADHD, ex…

OBJECTIVES: Urban transport is an important determinant of population health. Ensuring health is well considered in urban transport planning is important to create healthy cities, healthy populations and sustainable societies. This review aimed to describe how health is considered in urban transport planning. STUDY DE…

Indoor air pollution presents a critical public health challenge, particularly in countries such as India, where millions are exposed to harmful pollutants within their homes and workplaces. This scoping review delves into the multifaceted impacts of indoor air pollution on health outcomes, synthesizing evidence from v…

To uncover the clinical characteristics and investigate the underlying causes of psychiatric manifestations in patients with systemic lupus erythematosus (SLE), including its subset, neuropsychiatric systemic lupus erythematosus (NPSLE). Through comprehensive database searches in PubMed, Embase, Medline, and Cochrane,…