42,349 papers found

BACKGROUND: The clinical characteristics of craniomaxillofacial fibrous dysplasia (FD) have not been clearly identified. The objective of this meta-analysis is to assess the predominance of the monostotic form of FD using an evidence-based review. Furthermore, we examined the laterality and sex dominance of FD in patie…

The aim of this review was to summarize the studies on noise-induced hearing loss (NIHL) which were carried out in the countries of Central and Eastern Europe, South-East Europe, and former Soviet Union countries or Newly Independent States in the period from 1970 to 2012. The papers were identified by literature searc…

BACKGROUND: Home parenteral nutrition (HPN) is currently the management of choice for patients with chronic intestinal failure. AIM: To summarise the major issues in delivering long-term parenteral nutrition (>3 months) and assess outcome as per complications, mortality and quality of life. To assess the evidence for…

OBJECTIVE: 5α-reductases are a family of isozymes expressed in a wide host of tissues including the central nervous system (CNS) and play a pivotal role in male sexual differentiation, development and physiology. METHODS: A comprehensive literature search from 1970 to 2011 was made through PubMed and the relevan…

BACKGROUND: Orbscan scanning-slit optical pachymetry was introduced over a decade ago and yielded higher central corneal thickness (CCT) values to the "gold standard" of contact ultrasound pachymetry (U/S). An acoustic correction factor (AF) was introduced later to compensate for this difference. The goal of this revie…

BACKGROUND: Narcolepsy is currently categorized into three groups; narcolepsy with and without emotionally triggered loss of muscle tone (cataplexy), and narcolepsy secondary to other medical conditions. Many patients with hypersomnia are diagnosed too late. The article presents a review of this field. MATERIAL AND ME…

Our objective was to conduct a meta-analysis of therapeutic efficacy of pharmacological treatment of adult ADHD based on data from controlled clinical trials. We used the search engines PubMed and Medline to identify relevant clinical trials. Short-term studies with double-blind parallel-group design were selected for…

OBJECTIVE: To determine the effectiveness of orthodontic oral health promotion (OHP) upon gingival health. DATA SOURCES: The Cochrane Central Register of Controlled Trials [CENTRAL (January 2005)], MEDLINE [OVID and PubMed platforms (1966 to May 2005)] and EMBASE (1966 to May 2005) were searched. A grey literature sea…

OBJECTIVES: The aims of this review are to point out the determinants of oxygen saturation of the haemoglobin of mixed venous blood (SvO(2)), to specify the correlations existing between SvO(2) and central venous saturation in superior vena cava (ScvO(2)), to determine and finally to locate the current place of venous…

BACKGROUND: The insertion of central venous catheters (CVCs) may be associated with peri- and post-procedural bleeding. People who require a central line often have disorders of coagulation as a result of their underlying illness, co-morbidities or the effects of treatment. Clinical practice in some institutions is to…

BACKGROUND: Central nervous system lymphoma (CNSL) is aggressive, and treatment with Bruton tyrosine kinase (BTK) inhibitors (BTKis) plays a key role. For this systematic review and meta-analysis, the authors evaluated BTKis for the treatment of primary CNSL (PCNSL) and secondary CNSL (SCNSL). METHODS: By May 1, 2025,…

This study investigates the incidence of ischemic cerebrovascular disease (CVD), including ischemic stroke, silent stroke, and transient ischemic attack (TIA) or amaurosis fugax (AF), in patients with retinal artery occlusion (RAO). Subgroup analyses focus on RAO type and study site, exploring the association between s…

BACKGROUND: Pancreatic surgery is challenging owing to the anatomical characteristics of the pancreas. Increasing attention has been paid to changes in quality of life (QOL) after pancreatic surgery. AIM: To summarize and analyze current research results on QOL after pancreatic surgery. METHODS: A systematic search o…

INTRODUCTION: The evidence on efficacy of intravitreously administered Conbercept (IVC) monotherapy for diabetic macular degeneration was still limited. METHODS: A systematic review was conducted in November 2019 to summarize the current evidence on visual acuity (VA) changes with IVC monotherapy in the treatment of d…

This systematic review and meta-analysis was conducted to compare relapse rates and adverse effects with oral dexamethasone vs. oral prednisone for acute asthma exacerbations in pediatric patients.A computerized literature search of PubMed, Embase, Scopus, CENTRAL (Cochrane Central Register of Controlled Trials) and Go…

PURPOSE: The gut-liver interaction suggests that modification of gut bacterial flora using probiotics and synbiotics may improve liver function. This systematic review and meta-analysis aimed to clarify the effect of probiotics and synbiotics consumption on the serum concentration of liver function enzymes. METHODS: P…

BACKGROUND: Diabetic macular edema (DME) causes visual impairment in diabetic patients. Aflibercept is a standard treatment of DME; however, the benefit of combining it with laser therapy remains uncertain. METHODS: A systematic review of randomized controlled trials (RCTs) comparing aflibercept alone with a combinati…

BACKGROUND: Interspinous process devices (IPDs) have been widely promoted as a minimally invasive alternative to traditional decompressive surgery for lumbar spinal stenosis (LSS). However, their clinical durability, safety, and comparative effectiveness have remained controversial. This review aims to review and synth…

BACKGROUND: Sellar region tumors, such as craniopharyngiomas, pituitary adenomas, and chordomas, pose substantial surgical complexity. Although outcomes have improved, venous thromboembolism (VTE), particularly deep vein thrombosis (DVT), remains a significant postoperative risk. While prior studies report elevated VTE…

BACKGROUND: While magnetic resonance imaging (MRI) is increasingly used in the diagnostic workup of canine central nervous system (CNS) disorders, its role in neosporosis has not been systematically characterised. Numerous questions remain regarding optimal diagnostic approaches and treatment protocols, and large-scale…