42,349 papers found

BACKGROUND: Pancreatic surgery is challenging owing to the anatomical characteristics of the pancreas. Increasing attention has been paid to changes in quality of life (QOL) after pancreatic surgery. AIM: To summarize and analyze current research results on QOL after pancreatic surgery. METHODS: A systematic search o…

INTRODUCTION: The evidence on efficacy of intravitreously administered Conbercept (IVC) monotherapy for diabetic macular degeneration was still limited. METHODS: A systematic review was conducted in November 2019 to summarize the current evidence on visual acuity (VA) changes with IVC monotherapy in the treatment of d…

This systematic review and meta-analysis was conducted to compare relapse rates and adverse effects with oral dexamethasone vs. oral prednisone for acute asthma exacerbations in pediatric patients.A computerized literature search of PubMed, Embase, Scopus, CENTRAL (Cochrane Central Register of Controlled Trials) and Go…

PURPOSE: The gut-liver interaction suggests that modification of gut bacterial flora using probiotics and synbiotics may improve liver function. This systematic review and meta-analysis aimed to clarify the effect of probiotics and synbiotics consumption on the serum concentration of liver function enzymes. METHODS: P…

BACKGROUND: Diabetic macular edema (DME) causes visual impairment in diabetic patients. Aflibercept is a standard treatment of DME; however, the benefit of combining it with laser therapy remains uncertain. METHODS: A systematic review of randomized controlled trials (RCTs) comparing aflibercept alone with a combinati…

BACKGROUND: Interspinous process devices (IPDs) have been widely promoted as a minimally invasive alternative to traditional decompressive surgery for lumbar spinal stenosis (LSS). However, their clinical durability, safety, and comparative effectiveness have remained controversial. This review aims to review and synth…

BACKGROUND: Sellar region tumors, such as craniopharyngiomas, pituitary adenomas, and chordomas, pose substantial surgical complexity. Although outcomes have improved, venous thromboembolism (VTE), particularly deep vein thrombosis (DVT), remains a significant postoperative risk. While prior studies report elevated VTE…

BACKGROUND: While magnetic resonance imaging (MRI) is increasingly used in the diagnostic workup of canine central nervous system (CNS) disorders, its role in neosporosis has not been systematically characterised. Numerous questions remain regarding optimal diagnostic approaches and treatment protocols, and large-scale…

BACKGROUND: Older patients with cancer already represent the largest proportion of cancer survivors which will further increase in the upcoming years. However, older patients are highly underrepresented in clinical research, leading to a detrimental knowledge gap. Research on important aspects of quality of life (QoL)…

INTRODUCTION: Extrapulmonary manifestations of pulmonary arterial hypertension (PAH) may play a critical pathobiological role and a deeper understanding will advance insight into mechanisms and novel therapeutic targets. This manuscript reviews our understanding of extrapulmonary manifestations of PAH. AREAS COVERED:…

Diverse neurological symptoms have been reported in patients with SARS-CoV-2 disease (COVID-19), including stroke, ataxia, meningitis, encephalitis, and cognitive impairment. These alterations can cause serious sequelae or death and are associated with the entry of SARS-CoV-2 into the Central Nervous System (CNS). This…

The purpose of the present study was to determine the diagnostic accuracy of vaginal urea and creatinine levels in the detection of premature rupture of membrane (PROM). The Cochrane (central), EMBASE, PubMed, Scopus, and Web of Science were searched for studies published from the inception of the databases up to Janua…

OBJECTIVE: To propose an algorithm of treatment for sudden visual loss following filler injections and perform an English-written literature search for assignment of evidence level and grade recommendation. METHODS: Algorithm of treatment includes ocular physical Maneuvers, hyAluronidase administration, intravenous ST…

BACKGROUND: Molluscum contagiosum is a viral cutaneous infection in childhood that occurs worldwide. Physicians should familiarize themselves with this common condition. OBJECTIVE: To review in depth the epidemiology, pathophysiology, clinical manifestations, complications and, in particular, treatment of molluscum co…

BACKGROUND: Oncologic quality in colon cancer surgery hinges on achieving adequate longitudinal margins, lymphadenectomy, and mesenteric excision, yet international standards and segment-specific practices remain heterogeneous. METHODS: A focused PubMed/MEDLINE search from inception to October 2025 identified internat…

Rhodotorula species are basidiomycetous yeasts, commonly recognized as emerging opportunistic pathogens, particularly in immunocompromised patients. Fungemia is the most common presentation of Rhodotorula infections, which in the vast majority of cases is associated with the presence of central venous catheters (CVCs).…

Virtual reality (VR), a surging therapeutic tool especially in stroke rehabilitation, has emerged as a powerhouse for VR-based rehabilitation in stroke patients, which is not only restricted to motor dysfunction but also encompasses cognitive impairment. Given the central role of cognition in activities of daily living…

OBJECTIVE: To investigate the diagnostic and therapeutic approaches for M. hominis induced CNS infections in non-neonatal patients, raise clinical awareness, and provide insights for managing such cases. METHODS: A retrospective analysis was performed on the clinical presentation, laboratory findings, treatment, and p…

BACKGROUND: Managing health care acquired and device-associated intracranial infections in young children can be challenging given adverse antibiotic side effects and difficulties in achieving adequate central nervous system (CNS) antibiotic concentrations. Ceftaroline is a cephalosporin with a favorable safety profile…

Infection is one of the most commonly described complications, and a major cause of morbidity and mortality in pediatric patients treated using central venous catheters (CVCs). Taurolidine lock solutions have been used to decrease catheter-related bloodstream infections (CRBSIs) in both adult and pediatric patients. Th…