376,015 papers found

Meta-analysis of genome-wide association studies (GWAS) across diverse populations offers power gains to identify loci associated with complex traits and diseases. Often heterogeneity in effect sizes across populations will be correlated with genetic ancestry and environmental exposures (e.g. lifestyle factors). We pre…

PURPOSE: To summarize and analyze all the evidence available concerning marginal bone loss (MBL) and implant failure between tilted and axial implants. MATERIALS AND METHODS: An electronic literature search was conducted without any language restrictions, and only systematic reviews with meta-analysis or meta-analysis…

BACKGROUND: The human dystrobrevin binding protein 1 (DTNBP1) gene has been linked to risk for schizophrenia. Recent studies indicate that several single nucleotide polymorphisms (SNPs) in the DTNBP1 gene may also influence general cognitive ability in both schizophrenic patients and healthy control subjects. We examin…

OBJECTIVE: The authors conducted a meta-analysis of relevant data from primary studies of the genetic epidemiology of major depression. METHOD: The authors searched MEDLINE and the reference lists of previous review articles to identify relevant primary studies. On the basis of a review of family, adoption, and twin s…

Meta-analyses of randomized evidence may include published, unpublished, and updated data in an ongoing estimation process that continuously accommodates more data. Synthesis may be performed either with group data or with meta-analysis of individual patient data (MIPD). Although MIPD with updated data is considered th…

PURPOSE: Physical activity (PA) is important for the prevention and management of cardiovascular (CV) disease (CVD). We aim to investigate the effect of different types of exercise on cardiometabolic risk factors in these subjects with CV risk factors but no history of CVD is lacking. METHODS: PubMed and Scopus databa…

AIM: To evaluate the efficacy of active pedagogical strategies for teaching the nursing process compared to traditional teaching methods. DESIGN: Systematic review with meta-analyses performed according to the recommendations of Cochrane Handbook and reported according to Preferred Reporting Items for Systematic Revie…

BACKGROUND: Maternal mental health is a key determinant of maternal well-being, fetal development, and family harmony. Although various antenatal mental health interventions exist, their comparative efficacy needs further investigation. AIM: To evaluate Mindfulness-Based Childbirth and Parenting (MBCP), Mindfulness-Ba…

PURPOSE: We aimed to assess the impact of additional proximal margin (PM) resection on survival outcomes in patients with perihilar cholangiocarcinoma (pCCA) with intraoperative PM R1. METHODS: MEDLINE, Cochrane, Embase, and Web of Science databases were systematically searched from inception to November 2024. Studies…

BACKGROUND: Coronary small-vessel disease (SVD) remains challenging for percutaneous coronary intervention (PCI) because small lumens magnify restenosis and ischemic risk. Multiple devices are available, yet their comparative performance is uncertain. This study evaluated and ranked PCI strategies for SVD. METHODS: A…

BACKGROUND: The perinatal period spans from the onset of pregnancy to one year postpartum. Sleep quality is particularly critical during this period. An appropriate exercise regimen can significantly improve their sleep quality. Previous studies have demonstrated that exercise effectively enhances sleep quality; howeve…

UNLABELLED: The aim of this systematic review and network meta-analysis was to evaluate and rank the long-term effectiveness of conservative interventions for osteoporotic vertebral compression fractures (OVCFs). Teriparatide demonstrated the greatest efficacy for both pain relief and quality of life improvement, signi…

BACKGROUND: Colorectal cancer survivors frequently experience persistent fatigue, psychological distress, and reduced health-related quality of life (HRQoL) after treatment. Exercise is increasingly recognized as an effective nonpharmacologic intervention, but the comparative efficacy of different modalities remains un…

BACKGROUND: Chronic low back pain (CLBP) is a prevalent musculoskeletal disorder. Electrotherapy modalities such as high-frequency transcutaneous electrical nerve stimulation (HF-TENS), low-frequency transcutaneous electrical nerve stimulation (LF-TENS), and interferential current (IFC) are commonly used, yet their com…

OBJECTIVE: Considering safety and effectiveness of oral antihypertensive agents when treating hypertensive disorders of pregnancy, no preference can be stated between the 3 agents currently available. Therefore, this systematic review and network meta-analysis aims to determine the effects of antenatal treatment with m…

Sixty-five studies that evaluated the efficacy of multidisciplinary treatments for chronic back pain were included in a meta-analysis. Within- and between-group effect sizes revealed that multidisciplinary treatments for chronic pain are superior to no treatment, waiting list, as well as single-discipline treatments su…

Because published outcome studies are the only available source of data about the morbidity among surviving very low birthweight infants (VLBW, less than 1500 g) a search was carried out of 1136 references in the English language. A total of 111 outcome studies were found that reported morbidity data in cohorts of VLBW…

Corticosteroids are frequently advocated for use in prevention of postherpetic neuralgia (PHN), although their use is replete with controversy. The present study is a meta-analysis of the four well-controlled clinical studies conducted on this issue. The results indicated there is a statistically significant decrease i…

Therapeutic drug monitoring (TDM) is commonly employed to optimize the dosing of certain drugs, including digoxin, aminoglycosides, theophylline, and phenytoin. Studies were reviewed in order to (a) evaluate the effect of TDM on the occurrence of toxic drug reactions (TDRs) and (b) identify factors that may modify or i…

OBJECTIVE: To compare autologous stem cell (SC) at different doses combined with core decompression (CD) versus CD alone for osteonecrosis of the femoral head (ONFH), using conversion to total hip arthroplasty (THA) as the primary outcome. METHODS: PubMed, Embase, Cochrane Library, Web of Science, and CNKI were system…