44,672 papers found

BACKGROUND: Currently, there are many surgical options for patellar dislocation. The purpose of this study is to perform a network meta-analysis of the randomized controlled trials (RCTs) and cohort studies to determine the better treatment. METHOD: We searched the Pubmed, Embase, Cochrane Central Register of Controll…

Active exergaming for improving cognitive function is a relatively novel concept as it has certain unique features that could prove advantageous in improving patient outcomes, particularly in patients with neurological disabilities. Hence, we have conducted this review to obtain a comprehensive estimate of effectivenes…

BACKGROUND: The tic disorders are common neuropsychiatric disorders that affects the growth and development of children and adolescents. Chinese herbal medicine is commonly used for the treatment of tic disorders. However, there is no consensus on the difference in clinical efficacy compared with routine treatment. The…

BACKGROUND: Extraction is the foremost step to isolate the natural constituents from a medicinal plant and leads the process of development of herbal formulation from bench to bed. INTRODUCTION: In the field of extraction, the optimization approach helps in achieving better yield and quality where a response of concer…

COVID-19 is caused by SARS-CoV-2, which originated in Wuhan, Hubei province, Central China, in December 2019 and since then has spread rapidly, resulting in a severe pandemic. The infected patient presents with varying non-specific symptoms requiring an accurate and rapid diagnostic tool to detect SARS-CoV-2. This is f…

Glutamine is a conditionally essential amino acid widely used in sports nutrition, especially because of its immunomodulatory role. Notwithstanding, glutamine plays several other biological functions, such as cell proliferation, energy production, glycogenesis, ammonia buffering, maintenance of the acid-base balance, a…

is a valuable medicinal plant species among different ethnic groups in tropical Africa. The aim of the current study was to review existing literature on the ethnomedicinal uses, phytochemistry and pharmacological properties ofin an effort to evaluate the therapeutic potential of the species. The relevant information o…

Traumatic brain injury (TBI) is now characterized as a progressive, degenerative disease and continues to stand as a prevalent cause of death and disability. The pathophysiology of TBI is complex, with a variety of secondary cell death pathways occurring which may persist chronically following the initial cerebral insu…

BACKGROUND: Diving is a popular sport, and some recreational divers have medical risk factors. Their health can be endangered by high extracorporeal (ambient) pressure and its many systemic effects. METHODS: We review relevant publications on free (breath-hold) diving, scuba diving, medical evaluation for diving, baro…

AIMS: First, to discuss sex differences in auditory function between women and men, and whether cyclic fluctuations in levels of female sex hormones (i.e., estradiol and progesterone) affect auditory function in pre-menopausal and post-menopausal women. Second, to systematically review the literature concerning the dis…

BACKGROUND: Currently, there is no evidence-based medical evidence for the diagnosis of lymph node metastasis (LNM) of thyroid cancer (TC) by ultrasound combined with computed tomography (US + CT), and the results of various studies on its diagnostic efficacy are inconsistent. Therefore, the diagnosis of cervical LNM b…

Safe and reliable venous access is mandatory in modern health care, but central venous catheters (CVCs) are associated with significant morbidity and mortality, This paper describes current Swedish guidelines for clinical management of CVCs The guidelines supply updated recommendations that may be useful in other count…

Stimulant treatment with methylphenidate (MPH) and amphetamines (AMP) is first-line for children and adolescents with attention-deficit/hyperactivity disorder (ADHD), but quantitative guidance on comparative efficacy and dose selection within licensed dose ranges remains limited. This study aimed to compare dose-respon…

BACKGROUND: Natural products, including medicinal plants, have been explored for obesity management.contains the bioactive compound forskolin, which may influence body composition and weight regulation. This systematic review assessed the effectiveness and safety ofextract as an anti-obesity agent. METHODS: PubMed, Sc…

BACKGROUND: Non-compressible torso hemorrhage (NCTH) is a leading cause of preventable trauma death. Resuscitative thoracotomy (RT) has served as salvage intervention, while resuscitative endovascular balloon occlusion of the aorta (REBOA) has emerged as a less invasive alternative, though evidence remains discordant.…

PURPOSE: To evaluate the effect of standalone iStent inject implantation on intraocular pressure and the medication burden in patients with pseudoexfoliative (PEX) glaucoma, and to compare these findings with results reported for open-angle glaucoma without subtype stratification. MATERIALS AND METHODS: A search…

BACKGROUND: Cutaneous mucinoses are a heterogeneous group of disorders characterized by dermal accumulation of glycosaminoglycans, leading to a wide spectrum of clinical manifestations. Among these, pretibial myxedema (PTM), scleredema, scleromyxedema, and obesity-associated lymphedematous mucinosis represent clinicall…

BACKGROUND: Restricted ankle dorsiflexion from gastrocnemius tightness contributes to multiple foot and ankle disorders. Proximal medial gastrocnemius release (PMGR), originally developed for spasticity, is increasingly used for adult pathologies, yet its indications and outcomes remain debated. METHODS: We performed…

OBJECTIVE: To review the pharmacology, efficacy, and safety of zoliflodacin for the treatment of uncomplicated urogenital gonorrhea due toin adults and pediatric patients 12 years of age and older. DATA SOURCES AND EXTRACTION: A literature search was conducted in Scopus, Web of Science, PubMed Central, Gale Academic F…

Rheumatoid arthritis (RA), systemic lupus erythematosus (SLE), spondyloarthritis, calcium pyrophosphate deposition disease, and the therapies used to treat them, particularly disease-modifying antirheumatic drugs, exemplify clinical contexts where calcium homeostasis has underappreciated relevance. Calcium balance is c…