44,672 papers found

PURPOSE: The purpose of this study is to identify and evaluate to what extent the literature on team coordination during cardiopulmonary resuscitation (CPR) empirically confirms its positive effect on clinically relevant medical outcome. MATERIAL AND METHODS: A systematic literature search in PubMed, MEDLINE, PsycINFO…

OBJECTIVE: Catastrophizing is an exaggerated negative evaluation and attention to specific symptoms such as pain or fatigue. A number of studies consistently support the significant role of catastrophizing in pain. However, the role of catastrophizing in fatigue is less frequently investigated. This article provides a…

INTRODUCTION: Wilson's disease is an inherited disorder caused by a gene located on chromosome 13, which involved copper transportation across cell membranes. The disease can cause a reduced incorporation of copper into ceruloplasmin resulting in accumulation of this metal in the liver, central nervous system, kidneys…

BACKGROUND: The diagnostic value of a positive fecal occult blood test (FOBT) at the time of digital rectal examination (DRE) is disputed despite being used commonly by a significant number of physicians. A meta-analysis was conducted to evaluate FOBT by DRE for detecting neoplasia versus FOBT on stool passed spontaneo…

INTRODUCTION: Epilepsy and menopause have complicated interactions. Treatment of epilepsy may cause exacerbation of osteoporosis and alter the effects of hormone replacement therapy (HRT) whereas HRT may influence the frequency of seizures. MATERIALS AND METHODS: An extensive search was performed in the Cochrane Centr…

OBJECTIVE: To evaluate the efficacy and safety of vasodilators for sudden sensorineural hearing loss. METHOD: Based on the principles and methods of Cocharne Systematic Reviews, we searched the cochrane central register of controlled trials, PubMed, Embase, ISI, the China biological medicine datebase, VIP, CNKI and Wa…

OBJECTIVE: To review the physiologic functions and clinical significance of peripheral GnRH receptors. DESIGN: Literature review. All peer-reviewed journal articles published before 2010 on peripheral GnRH receptors were searched for in the Pubmed database, and relevant findings were summarized. RESULT(S): Peripheral…

PURPOSE: To determine, by systematic review of the literature, the prevalence of silent pulmonary embolism in patients with deep venous thrombosis. METHODS: Twenty-eight included published investigations were identified through PubMed. Studies were selected if methods of diagnosis of pulmonary embolism were described;…

AIM: This paper is an exploration of the concepts of advocacy and paternalism in nursing and discusses the thin line between the two. BACKGROUND: Nurses are involved in care more than any other healthcare professionals and they play a central role in advocating for patients and families. It is difficult to obtain a cl…

PURPOSE: To obtain an estimate of the magnitude of the problem of glaucoma in sub-Saharan Africa, and to evaluate the existing evidence for including glaucoma as a priority disease in our Vision 2020 programs in Africa. METHODS: A Pubmed search was carried out using "glaucoma prevalence Africa," "glaucoma presentation…

CONTEXT: Obesity has emerged as a global public health challenge. The objective of this review was to examine epidemiological aspects of obesity in the Western Hemisphere. EVIDENCE ACQUISITION: Using PubMed, we searched for publications about obesity (prevalence, trends, correlates, economic costs) in countries in Nor…

The incidence of heart failure (HF) is increasing as the population ages. Pharmacotherapy is an important component of treatment and yields significant improvements in survival and quality of life. In recent decades, exercise has gradually become accepted as an intervention beneficial to patients with HF, but more info…

Diagnostic lumbar puncture (LP) is essential to the diagnosis of central nervous system infections and subarachnoid haemorrhage. Life or limb-threatening adverse events due to the procedure are rare, but less severe complications may be common. Clinical practice in diagnostic LP is often not evidenced based. The aim of…

The MitoP2 database (http://www.mitop.de) integrates information on mitochondrial proteins, their molecular functions and associated diseases. The central database features are manually annotated reference proteins localized or functionally associated with mitochondria supplied for yeast, human and mouse. MitoP2 enable…

Complex regional pain syndrome (CRPS) is a chronic pain condition characterized by sensory, autonomic, and motor disturbances that can lead to significant functional impairment and decreased quality of life. The pathophysiology of CRPS is multifactorial and involves central and peripheral sensitization, autonomic dysfu…

BACKGROUND: The therapeutic relationship is meaningful and valuable to patients in rehabilitation and is positively associated with improved rehabilitation outcomes. Despite its central role, a comprehensive understanding of what constitutes the therapeutic relationship in physiotherapy and how it can be assessed is ye…

OBJECTIVES: Chronic pain affects 1 in 5 people and persists because protective nociception is converted into maladaptive neural, immune, and psychological states. This review aimed to consolidate mechanistic and clinical evidence to clarify that transformation and identify leverage points for durable relief. METHODS:…

BACKGROUND: Given the prevalence of osteoarthritis and the growing interest in alternative treatments, there is a need to provide a comprehensive evaluation of this integrated TCM approach. Reviews are required to understand the potential benefits and safety of the combination therapy compared to conventional treatment…

Most antimicrobial drugs need an intravenous (IV) administration to achieve maximum efficacy against target pathogens. IV administration is related to complications, such as tissue infiltration and thrombo-phlebitis. This systematic review aims to provide practical recommendations about diluent, pH, osmolarity, dosage,…

Central nervous system (CNS) infections constitute a life-threatening condition, especially in children. Treatment limitations exist for drug-resistant CNS bacterial infections. Inadequate CNS penetration and intravenous (IV) antibiotic treatment failure represent a major clinical challenge. However, patients with anti…