44,672 papers found

BACKGROUND: Pectoral (PECs) block was first described by Blancofor postoperative analgesia in breast surgery. It was proposed to be an easier and safer alternative to thoracic epidural or paravertebral block (PVB). In this systematic review and meta-analysis, we compare the perioperative analgesic efficacy and adverse…

BACKGROUND/OBJECTIVES: Fibrosing alopecia in a pattern distribution (FAPD) is a newly recognized form of scarring alopecia sharing characteristics of both androgenetic alopecia (AGA) and lichen planopilaris. The existing literature on FAPD and current understanding of the epidemiology, pathogenesis, clinical featu…

OBJECTIVE: To assess the efficacy and safety of bladder irrigation with amphotericin B for treatment of fungal infection in the urinary tract. METHODS: All the available randomized controlled trials (published before March, 2018) examining bladder irrigation with amphotericin B for treatment of urinary tract fungal in…

OBJECTIVE: To compare the clinical efficacy between subcuticular sutures and staples for skin closure after cesarean delivery. METHODS: PubMed, EMBASE, Cochrane Central Register of Controlled Trials, and Web of Science were searched. Only RCTs comparing subcuticular sutures to staples following cesarean delivery were…

OBJECTIVE: To provide a clinical overview of the antidepressant levomilnacipran. DATA SOURCES: Articles were identified by searching the MEDLINE, PubMed, Cochrane Library, and Clinicaltrials.gov databases through March 2014 using the keyword levomilnacipran. The manufacturer provided additional information from unpubl…

BACKGROUND: The comorbidity of constipation and mood disorders (anxiety/depression) creates a vicious cycle of symptom superposition and treatment resistance. The persistent "efficacy-tolerability" dilemma-whereby effective treatment for one condition may exacerbate the other-remains unresolved. METHODS: This narrativ…

The aseptic non-touch technique (ANTT) constitutes a standardized clinical framework designed to minimize infectious complications during intravenous therapy. Though widely acknowledged internationally, its uptake and supporting evidence within China's healthcare system have not been systematically clarified. This scop…

AIM: To identify and synthesise qualitative and quantitative evidence of nurse managers' qualities, practices and styles related to leading nurses' interprofessional collaboration. DESIGN: Mixed-methods systematic review. METHODS: Two authors independently selected studies based on predefined inclusion criteria, asse…

BACKGROUND: At least 60% of individuals with anxiety disorders report sleep disturbances, which might be explained by shared physiological mechanisms, including cortisol dysregulation and executive function skills disruption. The scientific literature regarding medical cannabis as a potential therapeutic candidate for…

INTRODUCTION: Following prolonged opioid and/or hypnotic exposure, iatrogenic withdrawal syndrome (IWS) can develop in critically ill patients due to improper cessation of these drugs. While IWS is well-documented in pediatric and neonatal intensive care unit (ICU), research on adult ICU patients remains scarce. This s…

OBJECTIVE: To decipher the role of body mass index (BMI) measured at treatment initiation on mortality rates in tuberculosis (TB). METHODS: This PROSPERO-registered PRISMA compliant review searched PubMed, Embase, CENTRAL, and Web of Science for studies from inception upto 10June 2024. Studies on adult patients examin…

OBJECTIVE: The clinical data of a child with complex parapneumonic effusion (PPE) caused by pneumofluke infection were analyzed, and the diagnosis and treatment of the disease were discussed through literature review. The effectiveness and safety of urokinase in the treatment of complex PPE and empyema caused by multip…

INTRODUCTION: Magnetic resonance imaging-guided focused ultrasound (MRgFUS) has shown promising results for a variety of neurological conditions, including movement disorders, brain tumors, and degenerative diseases. Recent clinical trials have demonstrated that MRgFUS can produce therapeutic effects in essential tremo…

The gut microbiome influences the metabolism and health of several organs beyond the gut and has recently gained considerable attention. The gut plays a central role in food digestion, absorption, nutrition, and general health. Hence, the gut microbiome has become a research subject for almost all health conditions. Im…

BACKGROUND: Dental stem cells with neurosphere-forming abilities are a promising cell source for the treatment of neural diseases and injuries. This scoping review aimed to systematically map the existing literature on dental sphere formation assays and their characteristics associated with neural regeneration potentia…

A narrative review was performed, analyzing peer-reviewed articles from databases such as PubMed, EMBASE, Scopus, and Web of Science to examine the mechanistic links between sleep-disordered breathing (SDB), and cardiac arrhythmias, emphasizing intermittent hypoxia, autonomic imbalance, and intrathoracic pressure swing…

PURPOSE: Histological grading of tumours is a well-established biomarker used to guide treatment in female breast cancer. However, its significance in male breast cancer remains unclear. This systematic review investigates the prognostic significance of tumour grade in relation to breast cancer-specific survival (BCSS)…

OBJECTIVE: Acute subdural hematoma (ASDH) is a common critical neurosurgical condition, often requiring immediate surgical intervention. Craniotomy and decompressive craniectomy are the 2 mainstay surgical approaches. This comprehensive review and meta-analysis aims to summarize the existing evidence and compare the ou…

OBJECTIVE: This review aimed to examine if the platelet-lymphocyte ratio and lymphocyte-monocyte ratio can be useful in determining disease activity in patients with inflammatory bowel disease. METHODS: PubMed, CENTRAL, Scopus, Embase, and Web of Science were searched for studies published up to 9 January 2023. Platel…

BACKGROUND: Locomotion problems in Parkinson's syndrome are still a research and treatment difficulty. With the recent introduction of brain stimulation or neuromodulation equipment that is sufficient to monitor activity in the brain using electrodes placed on the scalp, new locomotion investigations in patients having…