392,186 papers found

Human height is a very heritable trait as most of other human anthropometric traits. Genome-wide association studies have thus far identified about 200 genes associated with height with a genome-wide significance. Very large meta-analyses were needed to achieve this. These 200 height genes are involved in various biolo…

Migraine, especially migraine with aura is an established risk factor for ischemic lesions of the brain. Recent evidence has also linked migraine with and without aura to a broader range of ischemic vascular disorders including angina, myocardial infarction, coronary revascularization, claudication and cardiovascular m…

Both meta-analysis and traditional literature or narrative reviews strive to compile a great deal of information in an accessible and succinct manner. In recent years, social work researchers have been turning toward meta-analysis to identify issues in large areas of research. In order for meta-analysis to be a rigorou…

(1) A hypothesis has been proposed that artificial food colourings have a role in exacerbating hyperactive behavior in children; (2) A placebo-controlled, double-blind, crossover clinical study in 297 children representative of the general population showed higher hyperactivity scores during the periods when they were…

(1) A longitudinal cohort study showed an increase in the frequency of asthma among 7-year-old children who were treated with antibiotics during the first year of life, even when treatment was for non-respiratory tract infections. The risk increased with the number of antibiotic courses with the use of broad-spectrum a…

The major public microarray repositories Gene Expression Omnibus and ArrayExpress are growing rapidly. This enables meta-analysis studies, in which expression data from multiple individual studies are combined. To facilitate these types of studies, we developed Microarray Retriever for searching and retrieval of data f…

Several authors have studied or used the following estimation strategy for meta-analysing correlations: obtain a point estimate or confidence interval for the mean Fisher z correlation, and transform this estimate to the Pearson r metric. Using the relationship between Fisher z and Pearson r random variables, I demonst…

Given the prevalence and urgency of the childhood overweight problem, pediatric providers are searching for evidence-based management to translate into clinical practice, particularly in primary care. There are numerous challenges to translation and therefore to more widespread adoption of childhood overweight treatmen…

A systematic review is performed in attempt to answer a specific research question by means of objective, unbiased evaluation of all pertinent available evidence. Component primary studies are selected on the basis of quality, and, if possible, their results are combined mathematically by using a process known as meta-…

Meta-analysis is a vague descriptor used to encompass very diverse methods of data collection analysis, ranging from simple averages to more complex statistical methods. Holo-analysis is a fully comprehensive statistical analysis of all available data and all available variables in a specified topic, with results expre…

The primary studies in a meta-analysis of standardized mean differences generally include a mixture of single-factor t tests and multifactor analysis of variance designs. Accordingly, there is a need for effect-size measures in multifactor designs that are metrically comparable with measures in single-factor t tests. T…

The Cochrane Pregnancy and Childbirth database is an ongoing meta-analysis of evidence documenting effective health care practices for childbearing women and their neonates. It is proving invaluable to nurse educators, researchers, clinicians, and administrators working in a variety of health care delivery settings. Ev…

The distinction between schizophrenia (dementia praecox) and bipolar disorder (manic-depressive insanity), proposed by Kraepelin in 1896, was the subject of vigorous debate in the first decades of this century. The debate addressed fundamental questions about the principles underlying the nosology of psychiatric disord…

This article reports a secondary analysis of past therapy outcome meta-analysis. Fifteen meta-analysis provided effect sizes from 56 studies in previous reviews that met 1 of 3 increasingly stringent levels of criteria for clinical representativeness. The effect sizes were synthesized and compared with results from the…

Psychotherapy meta-analyses commonly combine results from controlled experiments that use random and nonrandom assignment without examining whether the 2 methods give the same answer. Results from this article call this practice into question. With the use of outcome studies of marital and family therapy, 64 experiment…

Meta-analysis has increasingly been used as an explanatory research tool. The present investigation was designed to illustrate the potential limitations of meta-analysis for making causal inferences. Several meta-analytic investigations have led others to conclude that gender differences are getting smaller over time,…

The objective of this review is how study quality is taken into account in the synthesis of information from several studies. Meta-analysis has been criticized for failing into account differential quality of evidence in primary studies, allowing poor studies to drive out good science by weight of numbers. Notwithstand…

Meta-analyses were performed on 34 samples that included correlations of the age and employee absenteeism relationship. Samples were categorized into 2 groups for voluntary absenteeism and involuntary absenteeism based on the frequency index and the time-lost index, respectively. Results indicated that both voluntary a…