44,672 papers found

This integrative review aims to provide a consolidated evidence-based appraisal of the most up-to-date guidelines and recommendations of international public and professional health regulatory bodies in relation to preparedness framework for restructuring safe delivery of dental services amid and beyond the coronavirus…

Multiple sclerosis (MS) is an immune-mediated demyelinating disease of the central nervous system. Studies have shown that MS disrupts several social cognitive abilities [including empathy and theory of mind (ToM)]. Overall ToM deficits in MS are well documented, but how the specific ToM subcomponents and empathic capa…

BACKGROUND: Multiple sclerosis (MS) is an inflammatory and degenerative neurological disorder of the central nervous system. Cognitive impairment is frequent in MS patients, which not only includes deficits in abilities assessed by traditional neuropsychological batteries, but also often features impairments in social…

BACKGROUND: Primary dysmenorrhea is the most common gynecological disorder in women of reproductive age. In East Asia, traditional herbal medicines have been used for a long time to treat symptoms of primary dysmenorrhea. Dangguijagyag-san (DJS) is one of the most widely known traditional herbal medicine for primary dy…

BACKGROUND: Several observational and preclinical studies have shown that blood transfusion may modify the mortality of patients with myocardial infarction (MI). The aim of this meta-analysis is to evaluate the recent evidence on the effectiveness of blood transfusion for all-cause mortality in patients with MI. MATER…

The cluster-randomized controlled trial is a design increasingly used in prevention and health care evaluation studies and is highly relevant to stroke research. However, there are methodological issues that make it complex to implement. These are not always fully appreciated, with reviews continuing to reveal deficien…

STUDY OBJECTIVES: Opioids have been reported to increase the risk for sleep-disordered breathing (SDB) in patients with noncancer chronic pain on opioid therapy. This study aims to determine the pooled prevalence of SDB in opioid users with chronic pain and compare it with patients with pain:no opioids and no pain:no o…

BACKGROUND AND OBJECTIVE: Pilot trials have suggested that pharmacotherapy may aid stroke recovery. The aim of this study was to systematically review the effects of antidepressants, anti-Alzheimer drugs, anti-Parkinson drugs, central nervous system (CNS) stimulants and piracetam on gross motor function, cognition, dis…

BACKGROUND: Low-dose heparin lock has been suggested as an effective and safe catheter lock in hemodialysis. However, whether a low-dose lock is superior to a high-dose heparin lock in preventing catheter-related infections and maintaining catheter patency is inconclusive. STUDY DESIGN: A systematic review and meta-an…

INTRODUCTION: Effective therapies for neurodegenerative disorders remain limited by the blood-brain barrier. However, improving delivery across this barrier is only one part of the challenge. Investigators must also determine whether a therapy reaches the intended brain region, engages its target, and produces a meanin…

Neuroendocrine prostate cancer (NEPC) is an aggressive, treatment-refractory phenotype of advanced prostate cancer. This narrative review was informed by targeted searches of PubMed, Web of Science through May 2026. We classify evidence as Level A (human NEPC samples or clinical cohorts), Level B (NEPC-specific models)…

Artificial intelligence (AI) is becoming increasingly visible in veterinary medicine, not only in diagnostic and decision-support applications but also in ways that may influence how clinical reasoning is structured. Because veterinary clinical decision-making is shaped by animal welfare, owner preferences, economic co…

BACKGROUND AND OBJECTIVES: The gut microbiome is a key determinant of overall health, impacting numerous bodily functions, such as those of the endocrine glands. The effect of the microbiota on thyroid function has become a matter of interest, more so since the revelation of the possible link between intestinal disease…

OBJECTIVE: Funding bodies such as Canada's Tri-Agency have implemented requirements for grant recipients to encourage improved research data management (RDM) practices and data sharing. Consequently, RDM and data sharing have become a higher priority for researchers and stakeholders supporting the research process, inc…

BACKGROUND: This bibliometric study scrutinizes the thematic evolution of research on stigma and discrimination in mental disorders, covering a span of five decades. It reflects on the shifting paradigms within the stigma-focused mental health research community from 1974 to 2024. METHODS: A comprehensive bibliometric…

Arrhythmia is an important cause of cardiovascular disease deaths and a serious threat to human health, but the current means of identification are limited. Biomarkers, with the advantages of easy access and rapid detection, have shown significant value in arrhythmia risk prediction, precision diagnosis, and prognosis…

Multidisciplinary meetings (MDMs) are increasingly central to spinal oncology, where complex decision-making must balance neurological, oncological, biomechanical, and systemic factors. This review aims to analyze the structure, clinical value, limitations, and future directions of MDMs in the management of spinal tumo…

Loiasis, a filarial vector-borne disease, is common in rural West and Central Africa. Benzimidazole derivatives albendazole and mebendazole are recommended as alternative treatments due to their perceived safety in hypermicrofilaremic patients. There is growing evidence that benzimidazoles might also lead to-associated…

BACKGROUND: Persons with dementia have increased risk of malnutrition due to several challenges. There is a wide range of interventions to improve nutritional status in persons with dementia. However, the evidence for such interventions is uncertain. AIM: To investigate the effect of therapeutic interventions to impro…

INTRODUCTION: Mild Behavioral Impairment (MBI) represents a predementia syndrome marked by neuropsychiatric symptoms that may precede detectable cognitive decline. Identifying factors associated with MBI is critical for developing targeted prevention strategies in neurodegenerative disorders. METHODS: This systematic…