376,015 papers found

BACKGROUND: Osteoporosis in men is an increasingly recognized health issue associated with reduced bone mineral density (BMD) and elevated fracture risk. While both antiresorptive and anabolic therapies are recommended in clinical practice, evidence directly comparing these drug classes in male populations remains limi…

BACKGROUND: To compare the effectiveness of multifactorial and exercise programs in preventing falls among older adults, with a specific focus on evaluating the individual and combined contributions of their key intervention components. METHODS: This study was a systematic review and component network meta-analysis. P…

INTRODUCTION: Many erectile dysfunction (ED) patients respond inadequately to phosphodiesterase type 5 inhibitors (PDE5is). Non-pharmacological interventions (NPIs) have emerged as potential alternative or adjunct treatments for improving erectile function. OBJECTIVES: This study aimed to evaluate and compare the effi…

BACKGROUND: Periodontitis is a chronic, multifactorial infectious disease affecting the oral cavity, destroying the periodontal supporting tissues, including alveolar bone resorption and loss of clinical attachment. These changes can result in the formation of intrabony defects and if left untreated, it can ultimately…

This Bayesian network meta-analysis evaluated the efficacy and safety of six prolyl hydroxylase inhibitors (PHIs) versus erythropoiesis-stimulating agents (ESAs) or placebo for chronic kidney disease (CKD) anemia. Electronic databases were searched through 1 May 2025. The prespecified primary outcome was change in hemo…

BACKGROUND: Acupuncture has been increasingly studied as an adjunctive treatment strategy for improving pregnancy outcomes in patients with poor ovarian response (POR). However, the effectiveness of different acupuncture types remains controversial. The purpose of this paper was to assess the effects of transcutaneous…

BACKGROUND: Survivors of digestive system cancers frequently experience depression, anxiety, fatigue, and impaired health-related quality of life (HRQoL). Exercise has emerged as a promising adjunctive therapy. However, the optimal modality and prescription remain unclear. This study aimed to evaluate the effects of ex…

INTRODUCTION: Preoperative anemia, affecting 10-30% of cardiac surgery patients, is a modifiable risk factor associated with increased transfusion needs and adverse outcomes. Current interventions (e.g., iron supplementation, erythropoietin (EPO), and autologous blood storage) lack consensus due to limited evidence and…

BACKGROUND: Reflux esophagitis (RE) is an important complication after proximal gastrectomy (PG) among proximal gastric cancer (PGC) patients. In recent years, different digestive reconstruction methods have been used to reduce the risk of RE. OBJECTIVE: To present and synthesize the clinical trial evidence regarding…

AimTo evaluate the efficacy of stem cell therapy from different sources on the ankle-brachial index, wound closure percentage, and wound closure time in the treatment of diabetic foot ulcers (DFUs).MethodsA literature search was conducted in PubMed, Embase, Cochrane Library's Central Register of Controlled Trials, and…

BACKGROUND: Approximately half of the world's population is infected with Helicobacter pylori (H.pylori), a bacterium shown to be linked with a series of gastrointestinal diseases. A growing number of systematic reviews (SRs) have been published comparing the effectiveness of different treatments for H.pylori infection…

Standard methods for meta-analysis of dose-response data in epidemiology assume a model with a single scalar parameter, such as log-linear relationships between exposure and outcome; such models are implicitly unbounded. In contrast, in pharmacology, multi-parameter models, such as the widely used Emodel, are used to d…

We report 34 infections by Plasmodium ovale found among 15,806 blood film examinations taken between 1973 and 1989 from several sites in Indonesia. Twenty five of the P. ovale infections occurred in a single sample of 514 people living in Owi, Irian Jaya. We detected five additional infections at 3 other sites in Irian…

This article discusses recent evidence pointing to an infectious etiology of premature rupture of the membranes and preterm labor. We conclude that antepartum infection is strongly related to preterm labor, premature rupture of the membranes and perinatal morbidity and mortality.

OBJECTIVES: To compare the effects of different interventions for maintaining smoking abstinence in postpartum individuals. METHODS: We searched PubMed, EMBASE, CENTRAL, CINAHL, PsycINFO, and ProQuest up to February 2024. Randomized controlled trials (RCTs) that studied the effects of any interventions on maintaining…

Tumor cell metabolism and the whole-body response to tumor metabolic activity produces a complex derangement, including alterations in carbohydrate oxidation with futile cycling and changes in gluconeogenesis and lipid utilization. An interplay between circulating hormones, lymphocyte-mediated cytokines, and tumor grow…

INTRODUCTION: Stable coronary artery disease (SCAD) is frequently accompanied by dyslipidemia, and residual lipid abnormalities persist despite pharmacological therapy. Exercise training has been shown to improve lipid metabolism, but the comparative efficacy of different exercise modalities remains unclear. EVIDENCE…

Meta-analysis enhances the power of rare variant association tests by combining summary statistics across several cohorts. However, existing methods often fail to control type I error for low-prevalence binary traits and are computationally intensive. Here we introduce Meta-SAIGE-a scalable method for rare varia…

OBJECTIVE: The aim of this study is to perform the first meta-meta-analysis on the effectiveness of parent-based interventions for children with externalizing behavior problems. Even though parent-based interventions are considered as effective treatments the effects reported in meta-analyses are heterogeneous and the…

The "information explosion" in the last 20 years has created a need for technique that synthesizes information from various sources. One of the methods for synthetasing information from various independent but similar studies is meta analysis. The aim of this study was to estimate complication rate of endomyocardial bi…