5,084,297 papers found

The evidence-based health care movement has generated new opportunity for scholars to generate synthesized sources of evidence. Systematic reviews are rigorous forms of synthesized evidence that scholars can conduct if they have requisite skills, time, and access to excellent library resources. Systematic reviews play…

BACKGROUND: Indigenous Peoples face a notable absence of standardized equity indicators for non-communicable diseases. Existing measurement models are rooted in Euro-Western biomedical frameworks that overlook Indigenous worldviews, definitions of health, and relational approaches to wellness. These models remain narro…

BACKGROUND: Occupational exposure to cytotoxic drugs is associated with various unfavorable health outcomes. This protocol reports a methodology for a systematic review and meta-analysis that aims to systematically review the published literature and quantify the level of environmental contamination of healthcare setti…

Repositioning is regarded as an important intervention to prevent the development of pressure injuries in patients who are immobile. However, there is uncertainty as to the optimal regimen in terms of frequency and method of repositioning. This commentary summarises and critically appraises a Cochrane systematic review…

Systematic reviews are an essential tool in identifying knowledge gaps and synthesizing evidence from in vivo animal research to improve human health. The review process follows an explicit and systematic methodology to minimize bias, but is not immune to biases or methodological flaws. Pre-registering a systematic rev…

Prenatal exposure to ambient air pollution and extreme temperatures are among the major risk factors of adverse birth outcomes and with potential long-term effects during the life course. Although low- and middle-income countries (LMICs) are most vulnerable, there is limited synthesis of evidence in such settings. This…

INTRODUCTION: Conducting a rigorous systematic review of animal studies requires a priori registration of a study protocol. However, it remains unknown how many of these registered studies culminate in publication and how long it takes to complete such a systematic review. Thus, this study had two objectives: (1) to as…

INTRODUCTION: Cancer affects not only patients but also their families, increasing the risk of stress-related illnesses among family members. Despite the development of various support interventions, family members continue to report unmet support needs, largely due to the limited implementation of these interventions…

BACKGROUND: Artificial intelligence (AI) tools are increasingly being used to assist researchers with various research tasks, particularly in the systematic review process. Elicit is one such tool that can generate a summary of the question asked, setting it apart from other AI tools. The aim of this study is to determ…

INTRODUCTION: The number of babies, children and young people with complex care needs (henceforth children with complex care needs (CCCN)) in England has increased in recent decades, and this has also been recognised globally. CCCN may have frequent and lengthy hospital admissions, but during these episodes, their need…

INTRODUCTION: Obesity has become one of the biggest public health problems of the 21st century. Prevalence of obesity in children and adolescents has increased dramatically worldwide over the last 20 years, and this trend is expected to continue. Obesity in childhood is concerning as it predicts obesity in adulthood, a…

BACKGROUND: Over the years, family-centered care has evolved as the "gold standard" model for the provision of healthcare services. With the advent of family-centered approach to care comes the inherent need to provide support services to caregivers in addition to meeting the functional needs of children with physical…

BACKGROUND: Systematic reviews have developed into a powerful method for summarising and synthesising evidence. The rise in systematic reviews creates a methodological opportunity and associated challenges and this is seen in the development of overviews, or reviews of systematic reviews. One of these challenges is how…

This is a protocol for a Cochrane Review (intervention). The objectives are as follows: The primary objective is to assess the effects of implementation interventions aimed at improving the uptake of evidence-based opioid prescribing by healthcare prescribers for adults with acute non-cancer pain, compared with no inte…

INTRODUCTION: Multidisciplinary teams (MDTs) are integral to oncology management, involving specialised healthcare professionals who collaborate to develop individualised treatment plans for patients. However, as cancer care grows more complex, MDTs must continually adapt to better address patient needs. This scoping r…

INTRODUCTION: Machine learning is a rapidly expanding field and is already incorporated into many aspects of medicine including diagnostics, prognostication and clinical decision-support tools. Epilepsy is a common and disabling neurological disorder, however, management remains challenging in many cases, despite expan…

The laborious and time-consuming nature of systematic review production hinders the dissemination of up-to-date evidence synthesis. Well-performing natural language processing (NLP) tools for systematic reviews have been developed, showing promise to improve efficiency. However, the feasibility and value of these techn…

BACKGROUND: Low back pain is a disability that occurs worldwide. It is a heterogeneous disorder that affects patients with dominant nociceptive, neuropathic, and central sensitization pain. An important pathophysiology of low back pain involves pain sensitization. Various nonoperative interventions are available for tr…