Searching PubMed for “Clinical Trial” and checking full-text availability…
for “Clinical Trial” · Showing 7,761–7,780 · 2039 ms
Verstraete M, Hendrickx H, Amery A·Medicina et pharmacologia experimentalis. International journal of experimental medicine
Abstract not available
Glatt M M·Psychiatria et neurologia
Abstract not available
Ryan D H, Kaiser P, Bray G A·Obesity research
Sibutramine is a novel new pharmacologic agent which is a specific reuptake inhibitor for norepinephrine and serotonin. Preclinical data show that sibutramine and its two metabolites reduce food intake of animals eating either high or low carbohydrate diets and of obese Zucker rats. An 8-week clinical trial showed a do…
Pirozynski T, Chiriţă V, Mungiu O C, +5 more·Revista medico-chirurgicala a Societatii de Medici si Naturalisti din Iasi
As compared to the psychopharmacological profile of amitriptyline hydrochloride the authors analyse the findings of a comparative clinical trial amitriptyline versus Tryptizol regarding their efficacy in neurotic and presenile depression. 170 inpatients divided into four comparative series were investigated. The drugs…
Goodall E, Oxtoby C, Richards R, +3 more·The British journal of psychiatry : the journal of mental science
Twenty-nine overweight schizophrenic patients maintained on depot neuroleptic injections who wished to lose weight took part in a double-blind, placebo-controlled trial of 30 mg D-fenfluramine. All subjects received dietary advice. Sixteen patients completed the 12-week trial. Rate of weight loss was significantly grea…
Ganança M M, Mangabeira Albernaz P L, Caovilla H H, +1 more·Pharmatherapeutica
Seventy-six patients with labyrinthine diseases of vascular origin were treated in a 6-week double-blind comparative study with either 400 mg pentoxifylline ('Trental') or 75 mg cinnarizine 3-times daily. Clinical evaluations, supported by audiological tests and vectornystagmography, were carried out before and after t…
Lelliott P T, Marks I M, Monteiro W O, +2 more·The Journal of nervous and mental disease
Five years after treatment in a controlled trial, in which all had received self-exposure homework, a group of 40 agoraphobic outpatients retained marked improvement in agoraphobia, mood, and free-floating anxiety. Frequency of spontaneous panics decreased as much in those who had placebo and self-exposure as in those…
Kvien T K, Høyeraal H M, Sandstad B·The Journal of rheumatology
Thirty-two patients with juvenile rheumatoid arthritis (JRA) entered a comparative, double blind, parallel 16-week clinical trial of azathioprine versus placebo. After 8 weeks of therapy the changes in disease activity measurements indicated an improvement in the azathioprine group compared to the placebo group. At the…
Adelusi B, Osoba A O, Adetoro O A, +3 more·African journal of medicine and medical sciences
Cases of post-abortal sepsis are admitted every day into the University College Hospital (UCH), Ibadan, Nigeria. This derives from the high incidence of induced (illegal) abortions in this environment. The infections are usually caused by mixed bacterial flora, often resistant to the common antibiotics because of the i…
Clark G M, Dowell R C, Pyman B C, +5 more·The Australian and New Zealand journal of surgery
The clinical trial of a multi-channel cochlear prosthesis has been carried out on 10 profoundly-totally deaf adult patients. Speech perception tests have shown that all the patients received significant benefit from the device. They obtained improvements in understanding running speech from 47% to 550% when using the d…
Al-Habbal M J, Al-Habbal Z, Huwez F U·Clinical and experimental pharmacology & physiology
A double-blind clinical trial was carried out on thirty-eight patients with symptomatic and endoscopically proven duodenal ulcer to compare the therapeutic responses to mastic (1 g daily, twenty patients) and placebo (lactose, 1 g daily, eighteen patients) given orally over a period of 2 weeks. Symptomatic relief was o…
Nilsson F, Norberg B, Frederiksen B, +1 more·Scandinavian journal of rheumatology
Polymorphonuclear leukocyte (PMN) chemotaxis is thought to play an essential role in the pathogenesis of rheumatoid arthritis. PMN chemotaxis is in part sensitive to microtubule antagonists (MAs), e.g. colchicine. The antimycotic antibiotic griseofulvin inhibits the MA-sensitive PMN chemotaxis in vitro in concentration…
Giacomantonio M, Bortolussi R, Gillis D A·Canadian journal of surgery. Journal canadien de chirurgie
The authors question the need to give prophylactic antibiotics perioperatively in all cases of acute appendicitis without perforation to reduce the rate of wound infection. A retrospective study of 82 patients showed a wound infection rate of 4.8%; 3 of 53 patients who did not receive antibiotics had a wound infection…
Perry T L, Wright J M, Hansen S, +4 more·Neurology
Isoniazid (INH) was given to nine patients with Huntington disease (HD) in a double-blind, placebo-controlled crossover trial. In an earlier open trial, three of six patients had improved, and one of them remained improved after 7 years on INH. Only one patient benefited in the present trial. All patients excreted smal…
Salvadeo A, Segagni S, Villa G, +3 more·International journal of clinical pharmacology, therapy, and toxicology
In a double-blind cross-over clinical trial, flutonidin (2-4 mg daily) was compared with timolol (20-40 mg daily) in the treatment of mildly or moderately hypertensive patients who concomitantly received fixed diuretic treatment. Each drug was administered for 1 month, with an interval of 2 weeks between the two monthl…
Taylor H R, Greene B M, Langham M E·Lancet (London, England)
In a double-blind controlled clinical trial comparing the safety and efficacy of oral diethylcarbamazine citrate (DEC) with topical DEC for the treatment of onchocerciasis twenty men with moderate skin-snip microfilarial counts received daily therapy for 1 week, then weekly therapy for the rest of 6 months. The number…
Bruni L, Califano A, De Angelis G, +7 more·The Journal of international medical research
In a controlled clinical trial undertaken in ten Italian centres, rifamycin SV was compared to associations of various drugs such as erythromycin, aureomycin, multivitamin preparations, etc, in the treatment of herpes zoster. Up to now 144 patients, suffering from herpes zoster at different localizations, were divided…
Strasser P H, Levy J C, Lamb G A, +1 more·Pediatrics
A randomized clinical trial of pediatric protocols administered by health assistants demonstrated an alternate method of handling telephone complaints in a large emergency room. The new system advised a higher medical examination rate than the current system in the emergency room probably bacause the current system has…
Fleiss J L, Chilton N W, Wallenstein S·Journal of dental research
Ridit analysis is presented as an appropriate method of analyzing dental clinical data which fall somewhere between the purely categorical (e.g., improved vs. not improved) and the bona fide quantitative (e.g., mg % salivary calcium) scales of measurement. The key feature of the method is the estimation of the probabil…
Zaccara G, Ferrara M, Ardito P·Rivista di patologia nervosa e mentale
Therapeutic efficacy of Nomifensine and Nortriptyline was compared with a double blind study on 29 patients suffering from several kinds of depression. The patients were admitted to the Institute of Nervous and Mental Diseases of the University of Florence. Drugs were administered according to a flexible dosage varying…