2,589 papers found

Recently it has been proposed a model for fibrils of human insulin in which the fibril growth proceeds via stacking LVEALYL (fragment 11-17 from chain B of insulin) into pairs of tightly interdigitated [Formula: see text]-sheets. The experiments have also shown that LVEALYL has high propensity to self-assembly and bind…

INTRODUCTION: Functional connectivity (FC) is the correlation between brain regions' activities, studied through neuroimaging techniques like fMRI. It helps researchers understand brain function, organization, and dysfunction. Hyperthyroidism, characterized by high serum levels of free thyroxin and suppressed thyroid s…

The diagnosis of atopic dermatitis (AD) remains primarily a clinical diagnosis, in which several clinical signs and symptoms including pruritus, the presence and location of skin lesions, and a personal or family history of atopic conditions are used to facilitate a diagnosis. In recent decades, several well-establishe…

This article aims to determine an association between vasculitis and cerebrovascular accidents (CVA) and the ideal management plan to decrease the chances of CVA in vasculitis patients. We also attempt to find a preferred treatment regimen that decreases the complications of CVAs in vasculitis patients, there…

OBJECTIVE: The purpose of this paper was to review the literature regarding the mechanisms leading to degeneration in intervertebral disks and to discuss contributing mechanical and biological factors. METHODS: The inclusion criteria for the literature review were research studies conducted in the last 3 decades with…

RATIONALE: The development of IVF techniques has diminished the importance of tubal infertility but recent discoveries shed a new light on reproductive tubal surgery prior to any IVF cycle. OBJECTIVE: To adapt current state of the art recommendations concerning tubal factor infertility to actual possibilities in Roman…

The impact of preoperative scintigraphy on the management of patients with primary hyperparathyroidism has been largely documented for more than two decades. More recently, preoperative scintigraphy has also been used to select patients for intraoperative detection of hyperfunctioning parathyroid glands thanks to a gam…

BACKGROUND AND AIMS: A gluten-free diet (GFD), the mainstay of treatment for celiac disease, is being increasingly adopted by people without this condition. The long-term health effects of this diet, apart from its beneficial effect on enteropathy in celiac disease, are unclear. Concerns exist that the GFD may result i…

A linear accelerator with the flattening-filter removed generates a non-uniform dose profile beam. We aimed to analyse and compare plan quality and treatment time between flattened beam (FB) and flattening-filter-free (FFF) beam to assess the efficacy of FFF beam for stereotactic body radiation therapy (SBRT). The sear…

BACKGROUND: The Internet has recently made possible the free global availability of scientific journal articles. Open Access (OA) can occur either via OA scientific journals, or via authors posting manuscripts of articles published in subscription journals in open web repositories. So far there have been few systematic…

The lacrimal sac (LS) is a dilated structure that lies in the lacrimal fossa, and the nasolacrimal duct (NLD) is the continuation of LS from its neck up to the inferior meatus of the nose. A study of 50 specimens of formalin-fixed adult cadavers of both sexes of Indian origin was conducted. The morphological features l…

OBJECTIVES: To determine the effect of glutathione S-transferases M1 and T1 polymorphisms on the risk of senile cataract among Egyptians. BACKGROUND: The glutathione S-transferases (GSTs) are polymorphic enzymes that are important in the protection against oxidative damage. METHODS: Using a multiplex polymerase chain…

OBJECTIVES: The aim of this prospective clinical study is to evaluate our 20-year experience with surgical treatment of pulmonary metastases in germ-cell testicular cancer and discuss the optimal therapeutical approach. BACKGROUND: Authors presents 63 patients who were surgically treated in the period from 1988 to 200…

UNLABELLED: The aim of the study was to evaluate the effect of photocoagulation and range of treatment on visual acuity (VA) in patients with diabetic macular edema. MATERIAL AND METHOD: 56 patients with type II diabetes mellitus--109 eyes were divided into four groups depending on the type of treatment. The evidence…

BACKGROUND: Benign schwannomas, also referred to as neurilemomas, neurinomas, and perineural fibroblastomas, are encapsulated nerve sheath tumors. Primary schwannomas of the liver are extremely rare. We present a case of liver schwannoma, incidentally found in a patient with breast cancer. CASE: A 66-year-old female c…

Accelerated atherosclerosis can lead to an increased prevalence of coronary artery disease, heart failure, brain stroke and peripheral arterial disease. Thus, subjects with chronic renal failure are exposed to increased morbidity and mortality from cardiovascular events. A strong and pervasive link exists between kidne…

Dyspeptic symptoms are quite common in chronic hemodialysis patients, and Helicobacter pylori (cagA(+)) is thought to play an important role in the pathogenesis of the active gastritis and other upper gastrointestinal mucosal lesions in these patients. The aim of this study was to evaluate a probable association betwee…

BACKGROUND: It is assumed that changes in different parts of the host defence mechanisms could influence the outcome by making way for extracranial complications. MATERIAL AND METHODS: For our study we enrolled 121 patients who had sustained various types of severe head injury (GCS 3-8). We investigated several labora…

AIM: Radiation-induced fibrosis is a recognised consequence of radiotherapy, especially after multiple and prolonged dosing regimens. There is no definitive treatment for late-stage radiation-induced fibrosis, although the use of autologous fat transfer has shown promise. However, the exact mechanisms by which this imp…