11,610,369 papers found

BACKGROUND: Hereditary pancreatitis (HP) was defined on a clinical basis alone until the first cationic trypsinogen gene (PRSS1) mutation was discovered through the initial phase of the current Pittsburgh Midwest Multi-Center Pancreatic Study Group (MMPSG) HP study in 1996, making genetic testing available. AIM: To ev…

Olfactory self-inspection has been observed in various mammals, including humans. This behaviour can help individuals to monitor own state, including health and hygiene. This study's aim was to explore the frequency of sniffing particular body parts and investigate possible gender differences. Further, we tested a poss…

OBJECTIVE: High-density lipoprotein (HDL) has well-characterized anti-atherogenic cholesterol efflux and antioxidant functions. Another function of HDL uncharacterized in rheumatoid arthritis (RA) is its ability to transport microRNAs (miRNAs) between cells and thus alter cellular function. The study's purpose was to d…

BACKGROUND: Accurate classification of non-small cell lung cancer (NSCLC) using morphological features has several limitations. However, the use of thyroid transcription factor 1 (TTF-1) and Napsin A as markers for the identification of various subtypes of NSCLC has shown promise. This meta-analysis was designed to eva…

The field of paleogenomics (the study of ancient genomes) is rapidly advancing, with more robust methods of isolating ancient DNA and increasing access to next-generation DNA sequencing technology. As these studies progress, many important ethical issues have emerged that should be considered when ancient Native Americ…

INTRODUCTION AND AIMS: Studies from many different countries have found associations between alcohol use, employment and social context. The aim of this study was to investigate associations between hazardous alcohol consumption (HAC), social vulnerability and employment conditions among Chilean adults. DESIGN AND MET…

To process the various stimuli in the real world effectively, it is essential to suppress salient distractions. Recent studies employing majority search paradigms found that people can suppress the capture of salient color singleton distractors even without knowing their color, which proved that suppressing a salient s…

This paper presents findings from a multisite study of 126 subjects meeting DSM-III-R criteria for Panic Disorder who also met criteria for a concurrent Major Depressive Episode, Dysthymia, or Depressive Disorder NOS. The study's primary aim was to discern the influence of varying degrees of depression on the comparati…

BACKGROUND: Cervical cancer develops in the cells of the cervix, the lower part of the uterus that connects to the vagina. It is primarily caused by persistent infection with high-risk types of the human papillomavirus (HPV), a common sexually transmitted virus. Raising awareness about its symptoms, risk factors, and p…

Key characteristics (KCs) are properties of chemicals that are associated with different types of human health hazards. KCs are used for systematic reviews in support of hazard identification. Transcriptomic data are a rich source of mechanistic data and are frequently interpreted through "enriched" pathways/gene sets.…

This study's purpose was to develop a direct MRI-based, deep-learning semantic segmentation approach for computing global longitudinal strain (GLS), a known metric for detecting left-ventricular (LV) cardiotoxicity in breast cancer. Displacement Encoding with Stimulated Echoes cardiac image phases acquired from 30 brea…

Heavy metal lead (Pb2+) is a pollutant and causes severe toxicity when present in human tissues especially the nervous system. Recent reviews have suggested that Pb2+ can target Ca2+-related proteins within neurons and that Ca2+ channels might be a candidate for Pb2+ entry. This study's main aim was to identify the fun…

OBJECTIVE: This study aimed to assess linagliptin's inhibitory effects on the proliferation of cervical cancer cell lines and investigate its potential for targeting human heat shock protein 90. METHODS: Linagliptin's cytotoxicity was assessed on a cervical cancer cell line (Hela cancer cell line) at two different inc…

OBJECTIVE: Environmental factors are important in the generation or aggravation of sensitive skin syndrome (SSS). Creams can be useful for patients with SSS, particularly when triggering factors cannot be avoided. Several clinical studies have investigated the safety and efficacy of specific creams in patients with SSS…

BACKGROUND: Despite the bourgeoning of digital tools for bioethics research, education, and engagement, little research has empirically investigated the impact of interactive visualizations as a way to translate ethical frameworks and guidelines. To date, most frameworks take the format of text-only documents that outl…

PURPOSE: Non-specific chronic low back pain (NSCLBP) patients present with reduced back extensor muscle endurance which could be explained by the higher fatigability of their lumbar muscles. However, studies investigating lumbar muscle fatigability have shown contradictory findings. Furthermore, none investigated poten…

INTRODUCTION: Arterial carbon dioxide tension (PaCO) abnormalities are common after cardiac arrest (CA). Maintaining a normal PaCOmakes physiological sense and is recommended as a therapeutic target after CA, but few studies have examined the association between PaCOand patient outcomes. This systematic review and meta…

PURPOSE: The study's purpose was to evaluate clinical manifestations of the female athlete triad among some elite Iranian athletes. METHODS: This cross-sectional study was conducted in three phases: 1) screening for menstrual irregularity (oligomenorrhea/amenorrhea) and/or stress fracture and weight-reducing drugs, 2)…

This study's objective was to identify, in a statistically valid and efficient manner, the risk factors associated with dental implant failure. We hypothesize that factors exist which can be modified by clinicians to enhance outcome. A retrospective cohort study design was used. Cohort members had >or= one implant plac…

BACKGROUND: Several studies have suggested a decrease in sexual function after risk-reducing salpingo-oophorectomy (RRSO) that is not mitigated by hormone therapy treatment. AIMS: This is a prospective cohort study of women followed from the time of diagnosis, including those who chose whether to proceed with RRSO, an…