44,655 papers found

OBJECTIVE: Population-based cohorts make it possible to study health and well-being trajectories during childhood and adolescence, their determinants, and their usefulness for informing public policies. The aim of this paper was to identify, compare, and synthesise population-based cohorts on child and adolescent healt…

Carbon dioxide (CO) angiography has emerged as an alternative contrast agent for arterial endovascular procedures, particularly in patients at increased risk of complications from iodinated contrast media (ICM). The present review evaluates the clinical circumstances in which carbon dioxide (CO) angiography can reduce…

Colorectal cancer (CRC) has shown significant heterogeneity regarding its response to immunotherapy. Long-lasting, beneficial effects have been observed in mismatch repair-deficient, microsatellite instability-high (dMMR/MSI-H) tumours, while mismatch repair-proficient, microsatellite stable (pMMR/MSS) tumours have rem…

OBJECTIVE: To systematically review relevant literature to assess the extent of acute kidney injury problems as a result of exposure to different poisons in subcontinental settings. METHODS: The Meta-Analysis was conducted in April 2025, and comprised search on PubMed, Cochrane Library, Web of Science, Embase, PubMed…

BACKGROUND: Atrial fibrillation (AF) is a prevalent arrhythmia associated with increased stroke risk, morbidity, and healthcare burden. Oral anticoagulation (OAC) is essential for stroke prevention, but adherence is often suboptimal. Smartphone-based mobile health (mHealth) applications offer potential to enhance adher…

PURPOSE: This systematic review and meta-analysis aimed to characterize etiological patterns of uveitis in individuals aged 60 years or older. METHODS: Following the PRISMA 2020 and MOOSE reporting guidelines, we searched PubMed/MEDLINE, Scopus, PubMed Central (PMC), and Web of Science (January 1, 2005-January 1, 2025…

Periprosthetic joint infection (PJI) remains a challenging complication after arthroplasty. Intraoperative direct sonication (sonicating explanted components or periprosthetic tissue in the operating room and inoculating processed fluid into blood culture bottles) may improve pathogen detection by disrupting biofilm. W…

BACKGROUND: Early mobilization (EM) has become essential for improved recovery after surgery, but its particular advantages in cardiac surgery populations have not been consistently reported. OBJECTIVE: To systematically evaluate the effects of early mobilization on functional recovery outcomes, hospital length of sta…

INTRODUCTION: School feeding programmes reach over 466 million children globally, making them one of the largest social safety nets worldwide. Beyond providing immediate nutritional benefits, school feeding programmes increasingly aim to strengthen local food systems through procurement from smallholder farmers,…

BACKGROUND: Depression is one of the most prevalent mental illnesses worldwide, significantly impairing patients' quality of life. As a modernized form of acupuncture, electroacupuncture (EA) has been widely applied as an adjunctive therapy for depression. In recent years, both clinical and mechanistic studies on EA ha…

BACKGROUND: Mental health disorders affect approximately 84 million people in the European Union (18.4% of the total EU population), with significant variations in preventive care approaches across member states. Despite growing policy attention, significant implementation gaps persist, particularly in Central and East…

Olanzapine long-acting injection (LAI) is a second-generation antipsychotic used in patients with schizophrenia-spectrum disorders, particularly those with poor adherence. However, evidence on its comparative efficacy, safety, and tolerability remains limited. We conducted a systematic review and meta-analysis followin…

OBJECTIVE: This scoping review aims to characterize the methodology and findings of head and neck cancer (HNC) literature utilizing deprivation indices. DATA SOURCES: Studies published in MEDLINE (PubMed), Embase (Elsevier), Cochrane Database of Systematic Reviews (Wiley), Cochrane Central Register of Controlled Trial…

OBJECTIVES: To synthesise and critically appraise evidence from randomised controlled trials directly comparing silver diamine fluoride with conventional restorative treatments for the management of cavitated dentinal caries in primary molars. DATA: Data on caries arrest and treatment failure or need for retreatment a…

INTRODUCTION: Therapy-associated thrombosis remains a challenge in the management of patients with acute lymphoblastic leukaemia (ALL). Thrombosis associated with asparaginase-containing chemotherapy complicates patient management strategies, prompting the need for effective prophylaxis. Assessing the relationship betw…

INTRODUCTION: Oral Lichen Planus is a chronic inflammatory disease and a potentially malignant disorder of the oral mucosa. We aimed to investigate the possibility of replacing the gold-standard steroids (ST) due to their propensity for drug tolerance and numerous associated side effects. Recently, calcineurin inhibito…

BACKGROUND: Inflammatory bowel disease (IBD), which encompasses Crohn's disease (CD) and ulcerative colitis (UC), is characterized by chronic inflammation of the gastrointestinal tract. Anemia is a common complication in patients with IBD, significantly impacting quality of life. Hepcidin, the primary regulator of iron…

AIM: To identify and describe instruments used to assess obstetric violence and evaluate their methodological quality and psychometric properties. DESIGN: A scoping review. DATA SOURCES: Ten databases [Medline (via PubMed), Web of Science, the Cochrane Library, Embase, Cumulative Index to Nursing and Allied Health Li…

INTRODUCTION: Scientific understanding of dental implant success has evolved significantly. Nowadays, it is well established that the long-term stability of an implant relies on osseointegration, a complex biological process directed by molecular and genetic signals at the bone-implant interface. This systematic review…

BACKGROUND: Prostate cancer is the second most commonly diagnosed cancer worldwide. Prostate biopsy, essential for definitive diagnosis, has evolved significantly with new technologies and techniques. Transrectal ultrasound-guided biopsy (TRUS-Bx) has been the gold standard but carries substantial infectious risks due…