44,655 papers found

OBJECTIVE: To evaluate the efficacy and safety of vonoprazan therapy as compared to conventional proton pump inhibitors (PPIs) or no vonoprazan for nonsteroidal anti-inflammatory drug (NSAID)-induced ulcers. METHODS: A literature search was conducted across databases (PubMed, Embase, Scopus, Cochrane CENTRAL, and Clin…

This systematic review aims to summarise the impact of exercise training on peripheral muscle fatigability in people with COPD, addressing different assessment methods and exercise interventions (endurance, resistance and combined training).PubMed, CENTRAL, CINAHL and PEDro databases and trial registers were searched f…

Bovine tuberculosis (bTB) has significant economic losses on the livestock productivity and poses serious public health risks worldwide. In Ethiopia, bTB is endemic and distributed across all parts of the country. Therefore, the systematic review aims to provide comprehensive investigations of the trends, risk factors,…

PURPOSE: Retinal vascular occlusion (RVO), a common reason for vision loss, is divided into central and branch RVO. Although age, hypertension, and diabetes are established risk factors, genetic variations in hemostasis-related genes like Prothrombin G20210A, Factor V Leiden, and MTHFR may also contribute. Yet, there i…

AIMS: Lubiprostone and its active metabolite may activate prostaglandin receptors, raising concerns about an increased risk of headache. We performed a systematic review and meta-analysis to identify whether lubiprostone increases the risk of headache. METHODS: To identify all relevant randomized controlled trials (RC…

Functional exercise training focuses on enhancing the body's capacity for everyday movements by targeting a combination of strength, stability, balance, coordination, and flexibility. More flexible and less standardized exercise approaches, such as functional exercise training, may offer further benefits on improving s…

BACKGROUND: Proficiency in clinical reasoning is crucial for achieving positive patient outcomes in healthcare. Nurses should take an active role in fostering their clinical reasoning skills. Bedside support strategies aim to offer practical, invaluable, and easily applicable resources for restructuring cognitive proce…

Schizophrenia (SCZ) remains a captivating mental disorder marked by complex symptomatology. Despite the success of the current therapeutic options for psychosis, a definitive cure remains elusive. Hence, this review explores mechanisms underlying SCZ pathophysiology, examining their potential as novel therapeutic targe…

INTRODUCTION: Chinese herbal medicine (CHM) taken orally is frequently utilized to enhance functional ability and independence in cerebral palsy (CP); nonetheless, there is a lack of current evidence regarding the efficacy of oral CHM in treating CP. Additionally, the general complexities of CHM prescriptions often obs…

Having a child with Down syndrome (DS) is stressful for families. Social, physical, economic and emotional difficulties are the most challenging stressors for parents of children with DS. Therefore, parents who have children with DS have used various types of coping strategies. This systematic review investigates relig…

BACKGROUND: There are established guidelines for pediatric oncology patients with neutropenic fever. However, half of pediatric oncology patients present with non-neutropenic fever. For this group, no established guidelines exist. OBJECTIVE: In this scoping review, we have explored the outcomes of non-neutropenic feve…

In cancer patients, physical and psychological issues are very common. There is a need for family support and high utilisation of healthcare resources commonly. Palliative care (PC) has grown in popularity to better fulfil of needs of patients and their families and potentially lowering hospital costs. Given that the m…

BACKGROUND: Lipomas and atypical lipomatous tumors or well-differentiated liposarcomas (ALTs/WDLs), pose a diagnostic challenge due to their overlapping clinical and imaging features. Accurate differentiation is crucial as treatment strategies differ significantly between benign lipomas and malignant ALTs/WDLs. In rece…

The global burden of hyperlipidemia is on the rise, along with an increase in associated cardiovascular complications. Since most of the patients affected by hyperlipidemia are elderly individuals with multiple comorbidities, the introduction of even a single additional drug for asymptomatic conditions such as hyperlip…

Occupational contact dermatitis (OCD) is an eczematous local inflammatory skin irritation caused by repeated use of hand sanitizer and other chemical substances. Occupational irritant contact dermatitis (OICD) and occupational allergic contact dermatitis (OACD) are the two variants of CD that cannot be identified clini…

Parkinson's disease (PD) is a degenerative neurological disorder resulting from the death of dopaminergic neurons, which, in turn, results in impaired motor and cognitive functions. Early diagnosis is important in achieving a good prognosis for PD. Currently, the only approved way to diagnose PD is through medical hist…

BACKGROUND: Faricimab stands as the inaugural and sole bispecific antibody approved by the US Food and Drug Administration (FDA) for intravitreal injection. Nonetheless, the efficacy and safety of intravitreal faricimab remained uncertain. OBJECTIVES: The purpose of this study was to evaluate faricimab. METHODS: This…

BACKGROUND: Albumin acts as a scavenger of reactive oxygen species and an inhibitor of inflammatory processes that underlie hepatic encephalopathy (HE). However, the role of albumin in hepatic encephalopathy is not well-established. The authors performed this meta-analysis to evaluate the efficacy and safety of albumin…

BACKGROUND AND AIMS: Solid pancreatic masses are sampled through tissue acquisition by endoscopic ultrasound (EUS). Inadequate samples may significantly delay diagnosis, increasing costs and carrying risks to the patients. AIM: assess the diagnostic adequacy of tissue acquisition using contrast-enhanced harmonic endos…

BACKGROUND: Percutaneous deep vein arterialization (pDVA) is considered a treatment modality in patients with no-option critical limb ischemia. However, there is still a paucity of evidence regarding its safety and efficacy. DATA SOURCES: MEDLINE (via PubMed), Embase and Web of Science databases as well as the CENTRAL…