42,326 papers found

Multidisciplinary meetings (MDMs) are increasingly central to spinal oncology, where complex decision-making must balance neurological, oncological, biomechanical, and systemic factors. This review aims to analyze the structure, clinical value, limitations, and future directions of MDMs in the management of spinal tumo…

Loiasis, a filarial vector-borne disease, is common in rural West and Central Africa. Benzimidazole derivatives albendazole and mebendazole are recommended as alternative treatments due to their perceived safety in hypermicrofilaremic patients. There is growing evidence that benzimidazoles might also lead to-associated…

BACKGROUND: Persons with dementia have increased risk of malnutrition due to several challenges. There is a wide range of interventions to improve nutritional status in persons with dementia. However, the evidence for such interventions is uncertain. AIM: To investigate the effect of therapeutic interventions to impro…

INTRODUCTION: Randomized controlled trials have suggested that tretinoin, a topical retinoid, can improve wrinkling in photodamaged skin; however, its overall effectiveness remains subject of debate. OBJECTIVES: This study evaluated the efficacy and safety of tretinoin in treating facial wrinkles induced by photodamag…

Parental labour migration is a widespread phenomenon in developing countries across Central and Eastern Europe and may impact the emotional security of Left-Behind Children (LBC) due to prolonged separation from primary attachment figures. In Romania, official data estimate that nearly 58,000 children have parents work…

INTRODUCTION: Mild Behavioral Impairment (MBI) represents a predementia syndrome marked by neuropsychiatric symptoms that may precede detectable cognitive decline. Identifying factors associated with MBI is critical for developing targeted prevention strategies in neurodegenerative disorders. METHODS: This systematic…

BACKGROUND: The article addresses one of the pivotal issues in the formation of suicidal behavior, namely the function of central and peripheral neurotransmitter systems and the mechanisms of neuroendocrine regulation. This article presents the relationship between alterations in lipid metabolism and suicidal behavior,…

The doctor shortage is a general healthcare problem on many remote islands, which differ geographically from the mainland. Revealing the factors for recruitment and retention of doctors on remote islands may help develop countermeasures. We systematically investigated the factors related to recruitment and retention of…

OBJECTIVE: The Glasgow prognostic score (GPS) is used to predict the prognosis of several cancers. This first systematic review and meta-analysis evaluated the role of GPS in predicting overall survival (OS) and progression-free survival (PFS) in patients with hematological malignancies. METHODS: Embase, PubMed, CENTR…

To compare the outcomes of rAAV2-ND4 injection in treated versus fellow eyes with Leber's hereditary optic neuropathy (LHON). The protocol was pre-registered on PROSPERO (CRD42023441669). PubMed, Ovid MEDLINE, Cochrane CENTRAL, Google Scholar, Embase, CrossRef, OpenAlex, and Web of Science were reviewed from 1990-2023.…

BACKGROUND: Gastric cancer (GC), a malignant epithelial tumor, is the fourth leading cause of cancer-related death worldwide. Therapeutic strategies for GC, despite the biggest challenges, can significantly improve survival rates through early detection and effective screening methods. AIM: To provide brief informatio…

BACKGROUND: Medulloblastoma is one of the common primary central nervous system (CNS) malignancies in pediatric patients. The main treatment is surgical resection preceded and/or followed by chemoradiotherapy. However, their serious side effects necessitate a better understanding of medulloblastoma biology to develop n…

INTRODUCTION: Despite the fact incidence and mortality vary widely among regions, sepsis remains a major cause of morbidity and cost worldwide. The importance of the endothelial barrier in sepsis and infectious diseases is increasingly recognized; however, the underlying pathophysiology of the endothelial barrier in se…

This review article presents an appraisal of pioneering technologies poised to revolutionize the diagnosis and management of aortic aneurysm disease, with a primary focus on the thoracic aorta while encompassing insights into abdominal manifestations. Our comprehensive analysis is rooted in an exhaustive survey of cont…

OBJECTIVE: To assess prognostic nutritional index (PNI) and controlling nutritional status (CONUT) score could predict overall survival (OS) and disease-free survival (DFS) in patients with breast cancer. METHODS: PubMed, Embase, ScienceDirect, CENTRAL, and Google Scholar were searched from 1January 2000 to 10October…

More than any other mental illness, the course, prognosis, and therapy of anorexia nervosa are shaped by the physical changes associated with being underweight. This article provides an overview of the endocrine changes associated with malnutrition and underweight. This overview serves as a basis for understanding the…

OBJECTIVES: The objective of this scoping review is to summarize the available information on types of telehealth services provided to older adults when physical therapy is involved in their delivery of care. Methods of clinical assessment and outcomes will also be identified. INTRODUCTION: Information on telerehabili…

BACKGROUND: Despite advancements in the treatment of psychosis, many patients continue to experience persistent symptoms and relapses during antipsychotic treatment, particularly when they fail to adhere to prescribed medications. Ayurveda explains psychotic disorders as "Unmada" and describes various treatment protoco…

OBJECTIVE: To determine which parameters of the currents used with electrotherapy in pelvic floor dysfunctions are more appropriate for the proposed objectives regarding the relief of the symptomatology of certain clinical conditions. MATERIAL AND METHODS: A systematic review was performed in CENTRAL, PubMed/MEDLINE a…

BACKGROUND: Protocadherin 10 (PCDH 10), a member of the superfamily of protocadherins, is a Ca2-dependent homophilic cell-cell adhesion molecule expressed on the surface of cell membranes. Protocadherin 10 plays a critical role in the central nervous system including in cell adhesion, formation and maintenance of neura…