44,649 papers found

OBJECTIVE: This systematic review will examine the association between pesticide use and cancer incidence among farm workers. INTRODUCTION: Farmers are the most essential part of many countries' agriculture-based economies. Several studies have identified acute and chronic hazards associated with pesticide use, includ…

BACKGROUND: Patients with small cell lung cancer (SCLC) face a poor prognosis and have limited treatment options, which has prompted the initiation of clinical trials. Overall survival (OS) is the gold-standard endpoint in clinical trials, reflects the benefits patients derive from interventions. Nevertheless, utilizin…

: Vernix caseosa peritonitis (VCP) is rare. Nonspecific symptoms of acute abdomen during early puerperium make preoperative diagnosis of VCP challenging. We aimed to identify risk factors, early diagnosis and treatment options, and the association between the timing and severity of VCP diagnosis and maternal outcomes.:…

BACKGROUND: Older adults with cognitive impairment are at increased risk of falls due to impaired judgment, balance, and mobility. The effectiveness of fall prevention interventions in this population remains unclear. OBJECTIVE: To investigate the effects of fall prevention interventions on fall incidence in older adu…

BACKGROUND: Kundalini Yoga (KY) integrates breathwork, meditation, dynamic movement, and chanting, and has gained recognition as a therapeutic intervention. Despite promising results from individual randomized controlled trials (RCTs), to our knowledge, no systematic review has exclusively synthesized RCT evidence on K…

BACKGROUND AND OBJECTIVES: The management of ITP has evolved with evidence-based international guidelines. However, Iraq's unique challenges, including variations in clinical practice and treatment disparities, necessitate localized guidance to bridge global recommendations and real-world practice. This expert consensu…

PURPOSE: Epilepsy is highly prevalent among children, making it one of the most common neurological diseases in the pediatric population. Its diagnosis is problematic, largely depending on clinical judgment and inaccurate investigative studies. Thus, a more objective investigation is warranted. MicroRNAs (miRNAs) are s…

Depression, a pervasive and disabling mental health disorder, presents a global healthcare challenge. Despite persistent research on its etiology and pathophysiology, many aspects remain unclear. Predominant neurobiological research and traditional pharmacotherapies have pointed out the monoamine hypothesis as a pivota…

PURPOSE: This systematic review and meta-analysis aimed to investigate whether early oral fluid intake after surgery compared with delayed oral intake causes nausea and vomiting in pediatric patients who underwent general anesthesia in the postanesthesia care unit (PACU). DESIGN: Systematic review and meta-analys…

OBJECTIVE: The impact of maternal exposure to outdoor particulate matter during pregnancy on preterm birth is still inconsistent, particularly under the unique atmospheric particulate matter pollution conditions in China, where the effects on preterm birth remain poorly understood. The study intends to evaluate the cor…

A considerable amount of morbidity and disability are caused by a wide variety of neurological illnesses together referred to as neurodegenerative diseases. Among them, Alzheimer's and Parkinson's diseases are the most prevalent and have been thoroughly studied. The development of intervention techniques that focus on…

INTRODUCTION: Conservative surgery is the gold standard for the treatment of single and small tumors and, combined with the concept of oncoplastic tumors, brings good aesthetic results while maintaining cancer safety. The objective was to comparatively analyze the degree of satisfaction of patients undergoing breast co…

OBJECTIVE: This study aims to assess the effectiveness of 5% dextrose (D5W) in comparison to corticosteroids for treating carpal tunnel syndrome (CTS). DATA SOURCES: A comprehensive systematic search was conducted across MEDLINE (PubMed), Embase, and the Cochrane Central Register of Controlled Trials on November 13, 2…

OBJECTIVES: This review will map the various methodological approaches used in graded dental ceramics and distinguish their material characteristics and properties. The aim is to identify gaps in the development and application of grading in dental ceramic systems. INTRODUCTION: The advantage of functionally graded ma…

PURPOSE: To compare the influence of immediate loading (IL) and non-immediate loading (NIL) protocols on overdentures retained by reduced-diameter implants (≤ 3.5 mm). MATERIALS AND METHODS: Electronic databases including MEDLINE (via PubMed), Embase, and the Cochrane Central Register of Controlled Trials were…

There is no consensus on the efficacy of perioperative immunonutrition in patients with upper gastrointestinal (GI) cancer surgery. We clarified the impact of perioperative immunonutrition on postoperative outcomes in patients with upper GI cancers. We searched MEDLINE (PubMed), MEDLINE (OVID), EMBASE, Cochrane Central…

AIM: 3Mixtatin (a combination of Metronidazole, Minocycline, and Ciprofloxacin along with statins) is a novel biomaterial in pulp therapy, while Mineral Trioxide Aggregate (MTA) is considered the gold standard in endodontics. This study aimed to compare the clinical and radiographic success rates of MTA and 3Mixtatin i…

The aim of this systematic review is the assessment of the effect of mouth breathing on the prevalence of tongue thrust. The review was performed according to the PRISMA 2020 checklist guidelines, and the protocol was registered with PROSPERO (CRD42022339527). The inclusion criteria were the following: studies of clini…

OBJECTIVE: While clinical trials exploring stem cells for regenerating periodontal tissues have demonstrated positive results, there is a limited availability of systematic literature reviews on this subject. To gain a more comprehensive understanding of stem cell interventions in periodontal regeneration, this meta-an…

BACKGROUND: This systematic review explores the most current evidence regarding the mechanisms of neuropathic pain in patients with different types of diabetes and how this pain affects different functional and structural components of the neuroanatomical pain pathways. The review also seeks to provide guidelines for t…