42,326 papers found

BACKGROUND: There is increasing recognition that deep venous thrombosis (DVT) is a complicating factor in some children with acute hematogenous osteomyelitis. The similarity in signs and symptoms of osteomyelitis and DVT make clinical recognition of this complicating condition difficult. It would be helpful to the clin…

BACKGROUND: Fluconazole could be an alternative to terbinafine and itraconazole for onychomycosis treatment. However, it is difficult to determine the optimal dosing regimen due to the variability in causative agents, dosing regimens and cure rates in clinical trials. By restricting the data to dermatophyte onychomycos…

In the United States, it is estimated that between 6000 and 18,000 individuals each year present with disabling pain after inguinal hernia repair. Although surgical treatment with mesh removal is one of few options available, effective alternatives to nonsurgical management are needed. The use of pulsed radiofrequency…

UNLABELLED: PubMed search was performed using the key words: NF-?B, nuclear factors, asthma. Articles were selected based on their relevance to this review. OBJECTIVE: To review the literature regarding the involvement of the nuclear factor kappa-B (NF-?B) transcription factor in asthma. RESULTS: NF-?B is a critical…

INTRODUCTION: We asked whether the mobile-bearing knee prostheses could offer clinical and radiographic advantages over the fixed-bearing knee prostheses. MATERIALS AND METHODS: We conducted a systematic review and meta-analysis to evaluate the validity of this theory. We searched PubMed, EMBASE, Ovid and the Cochrane…

PURPOSE: To identify worksite practices that show promise for promoting employee weight loss. DATA SOURCE: The following electronic databases were searched from January 1, 1966, through December 31, 2005: CARL Uncover (via Ingenta), CDP, CINAHL, Cochrane Central Register of Controlled Trials, Cochrane Library, CRISP,…

INTRODUCTION: Denture cleaning should be quick and easy to perform, especially in long-term care facilities. The lack of proper oral hygiene can put older adults at higher risk from opportunistic oral infections, particularly fungal. As an alternative to regular brushing, the use of a microwave oven has been suggested…

CONTEXT: Medicinal plants are nature's gift to human beings to make disease free healthy life, and play a vital role to preserve our health. They are believed to be much safer and proven elixir in the treatment of various ailments. The genus Artemisia (Astraceae) consists of about 500 species, occurring throughout the…

OBJECTIVES: Oxytocin (OT) has long been implicated in maternal bonding, sexual behavior and social affiliation behaviors. This paper reviews the wide effects of oxytocin and its key role in well-being. METHODS: Studies were identified through Medline, Pubmed, and PsychINFO search of the English-language literature fro…

OBJECTIVE: To review the central role of leukemia stem cells (LSCs) in drug resistance and metastasis, aiming to provide key insights into leukemogenic pathology and developing novel therapeutic strategies against the relapse of leukemia. DATA SOURCES: The data used in this review were obtained mainly from the studies…

OBJECTIVE: To describe the evolution of the epidemiological research on physical activity in Brazil. METHODS: A systematic review of the literature was carried out in electronic databases (Medline/PubMed, Lilacs, Ovid, Science Direct, BioMed Central and High Wire), non-indexed Brazilian journals, query by specific aut…

DATA SOURCES: The Cochrane Oral Health Group Trials Register, Cochrane Central Register of Controlled Trials, Medline, PubMed and Embase databases were searched. The reference lists in relevant papers were checked. STUDY SELECTION: Studies chosen were randomised controlled trials and controlled clinical trials that co…

Thrombotic events in patients with inherited bleeding disorders occur only rarely. However, in some cases, the co-existence of acquired or inherited prothrombotic risk factors may overcome the hypocoagulative state, modulating the clinical phenotype to a decrease in bleeding symptoms or even to an increase in the likel…

BACKGROUND: Fluoroquinolones (FQs) are second-line antimicrobial agents. Once the decision to prescribe an antimicrobial is made, the choice of antimicrobial should be based on both the benefits and adverse effects. This systematic review quantifies the occurrence of common adverse events (AEs) related to FQs in relati…

BACKGROUND: Early mobilization (EM) has become essential for improved recovery after surgery, but its particular advantages in cardiac surgery populations have not been consistently reported. OBJECTIVE: To systematically evaluate the effects of early mobilization on functional recovery outcomes, hospital length of sta…

INTRODUCTION: School feeding programmes reach over 466 million children globally, making them one of the largest social safety nets worldwide. Beyond providing immediate nutritional benefits, school feeding programmes increasingly aim to strengthen local food systems through procurement from smallholder farmers,…

BACKGROUND: Depression is one of the most prevalent mental illnesses worldwide, significantly impairing patients' quality of life. As a modernized form of acupuncture, electroacupuncture (EA) has been widely applied as an adjunctive therapy for depression. In recent years, both clinical and mechanistic studies on EA ha…

Olanzapine long-acting injection (LAI) is a second-generation antipsychotic used in patients with schizophrenia-spectrum disorders, particularly those with poor adherence. However, evidence on its comparative efficacy, safety, and tolerability remains limited. We conducted a systematic review and meta-analysis followin…

BACKGROUND/OBJECTIVES: While traditional sports nutrition emphasizes high carbohydrate intake for endurance athletes, trained athletes may achieve metabolic adaptation to low-carbohydrate and ketogenic diets with maintained or improved performance outcomes. This systematic review and meta-analysis synthesize evidence o…

INTRODUCTION: Therapy-associated thrombosis remains a challenge in the management of patients with acute lymphoblastic leukaemia (ALL). Thrombosis associated with asparaginase-containing chemotherapy complicates patient management strategies, prompting the need for effective prophylaxis. Assessing the relationship betw…