11,606,371 papers found

PURPOSE: The purpose of this study was to consider how human rights concepts developed by the international human rights movement could contribute to advocacy efforts on behalf of the aging in an era of population aging. DESIGN AND METHODS: This study evaluated changes in popular perceptions of aging, the concomitant…

BACKGROUND: The emergency rescue ability of firefighters is particularly important in the event of major disasters or accidents. Therefore, an assessment of the firefighter-training effectiveness is necessary. OBJECTIVE: This paper aims to achieve a scientific and effective assessment of the firefighter-training effec…

PURPOSE: Mesial temporal lobe epilepsy (MTLE) is a common epileptic disorder. Although likely multifactorial, the mechanisms underlying the etiology and pathogenesis of the disease remains unknown in majority of patients. Viruses, particularly Human Herpes Virus 6A and B (HHV-6), two neurotropic herpes viruses, have be…

While the disclosure of research findings is relevant to all types of biomedical research, it has garnered particular attention with respect to genetics and genomics research due to some of the unique aspects of the data and the high public profile of the field. In this chapter, we review the attitudes of stakeholders…

Autism Spectrum Disorder (ASD) is defined by distinctive socio-cognitive behaviors that deviate from typical patterns. Notably, social imitation skills appear to be particularly impacted, manifesting early on in development. This paper compared the behavior and inter-brain dynamics of dyads made up of two typically dev…

This article considers 2 types of standard by which health technology assessment (HTA) studies should be judged: methodological and social. Methodological desiderata specify characteristics of a good quality analysis and should be met regardless of context. Transparency about an HTA study's perspective (eg, specifying…

BACKGROUND: Within implementation science studies, contextual analysis is increasingly recognized as foundational to interventions' successful and sustainable implementation. However, inconsistencies between methodological approaches currently limit progress in studying context and guidance to standardize the use of th…

This chapter focuses on the development and evaluation of prediction models for heart failure using machine learning techniques. By analyzing patient characteristics and applying algorithms such as random forest, gradient boosting, and others, highly accurate predictions were achieved. The findings demonstrate that mac…

We read the study of Bhatt and colleagues titled "Longitudinal changes in cognitive and physical function and health-related quality of life in older adults with acute myeloid leukaemia" published in Journal of Geriatric Oncology in January 2024. We commented in regards to the importance of the wording to be used when…

BACKGROUND AND AIM: The gut barrier protects the liver through tight junctions, which are disrupted in liver disease either from dysbiosis, inflammation, or the effects of ingested compounds such as alcohol. Strengthening of the gut barrier may ameliorate liver injury of varying etiologies. Short chain fatty acids (SCF…

Different regulatory agencies provide criteria for selecting a reference product for bioequivalence (BE) studies. In most cases, the criteria vary from one regulatory agency to another, and, consequently, the generic companies often have to repeat the BE studies comparing the same test product with the reference produc…

Working on a moving platform can significantly impede human performance. Previous studies on moving vehicles have often focused on the overall impact on general task performance, whereas our study's emphasis is on precise hand movements, exploring the interaction between body motion and the escalation of task difficult…

To review the state of research on the association between common chronic health conditions and academic outcomes, the authors reviewed published studies investigating the association of school attendance, cognitive ability, and achievement with a number of chronic diseases. Tables with brief descriptions of each study…

To ensure effective administration of probiotics in clinical practice, it is crucial to comprehend the specific strains and their association with human health. Therefore, we conducted a systematic review and meta-analysis to evaluate the scientific evidence on the impact of Lactiplantibacillus plantarum probiotic cons…

This article was written to reflect the importance of a correct quantification of the complexity of the elderly patient and its potential possibilities in clinical practice. From the decision to perform a laboratory test to the decision of the benefits of a determinate surgery through adjusting pathologies in several s…

Through the Human Microbiome Project, research on human-associated microbiomes has been conducted in various fields. New sequencing techniques such as Next Generation Sequencing (NGS) and High-Throughput Sequencing (HTS) have enabled the inclusion of a wide range of features of the microbiome. These advancements have a…

OBJECTIVE: To find out the prevalence of bullying among primary school students in an urban centre, and to categorise its types. METHODS: The descriptive, cross-sectional study was conducted from October 1, 2018, to March 31, 2019, in Baghdad, Iraq, and comprised primary school children of either gender aged 9-15 year…

UNLABELLED: Quercetin is a dietary flavonoid purported to improve human endurance exercise capacity. However, published findings are mixed. PURPOSE: The study's purpose was to perform a systematic review of the literature and meta-analysis to examine whether quercetin ingestion increases endurance exercise capacity.…

In this article, I extend the use of probability of success calculations, previously developed for fixed sample size studies to group sequential designs (GSDs) both for studies planned to be analyzed by standard frequentist techniques or Bayesian approaches. The structure of GSDs lends itself to sequential learning whi…