376,071 papers found

Despite advancements in treatment, diabetic foot ulcers (DFU) are challenging to heal, and the comparative efficacy of debridement strategies is poorly understood. This study assessed the effectiveness and ranked debridement methods for DFU based on wound size reduction (WSR). We conducted a Bayesian network meta-analy…

OBJECTIVE: To systematically evaluate the effects of different exercise interventions on sleep quality improvement in patients with cancer and compare the relative effectiveness of various exercise programs using a network meta-analysis, providing evidence-based guidance for developing personalized exercise interventio…

OBJECTIVES: Nutrition support improves ICU patients' nutritional status and outcomes, but optimal models remain unclear. We performed a Bayesian and frequentist network meta-analysis (NMA) and systematic review to assess improvements in nutritional indicators and clinical outcomes. METHODS: We systematically searched…

INTRODUCTION: Obstructive sleep apnea (OSA) is a prevalent condition associated with an increased risk of multiple adverse health outcomes. CPAP is the standard treatment. However, poor adherence has increased interest in alternative and combined non-invasive therapies. OBJECTIVE: This network meta-analysis compares t…

Improving population well-being is increasingly recognized as a global priority, yet evidence on the comparative effectiveness of well-being-focused interventions in adults is fragmented. Here we conduct a preregistered systematic review and network meta-analysis (PROSPERO CRD42023403480) of randomized controlled trial…

INTRODUCTION: Percutaneous nephrolithotomy (PCNL) is a common surgical procedure for the removal of kidney stones. Adequate postoperative analgesia is crucial for enhancing recovery and minimizing complications. Peripheral nerve blocks (PNBs) have emerged as a promising method for managing postoperative pain in PCNL pa…

Multi-gene panel testing allows efficient detection of pathogenic variants in cancer susceptibility genes including moderate-risk genes such as ATM and PALB2. A growing number of studies examine the risk of breast cancer (BC) conferred by pathogenic variants of these genes. A meta-analysis combining the reported risk e…

BACKGROUND: The best initial strategy for managing epistaxis is unclear. We performed a systematic review and network meta-analysis (NMA) to compare the effectiveness of various noninvasive treatments for patients with epistaxis. METHODS: We searched PubMed, Embase, and the Cochrane Library from inception to September…

Hepatic veno-occlusive disease is a serious regimen-related toxicity in patients undergoing hematopoietic stem cell transplantation. We performed a systematic review and meta-analysis of the literature on the effect of anticoagulation in preventing veno-occlusive disease. Several databases and online journals were sear…

To study the effect of transfusion on recurrence of squamous cell carcinoma of the head and neck, we analyzed the records of 143 patients with stage II through IV squamous cell carcinoma of the supraglottic larynx or hypopharynx for whom follow-up to recurrence or 5 years after surgical therapy was available. Variables…

PURPOSE: Our main purpose was to determine whether the addition of thoracic radiation therapy to systemic chemotherapy improves 2-year survival, improves local (intrathoracic) tumor control, and affects treatment-related mortality in patients with limited-stage small-cell carcinoma of the lung. DESIGN: Eleven randomiz…

This meta-analysis was performed to determine the efficacy of digoxin, verapamil, and beta-adrenoceptor blockers as prophylaxis against supraventricular arrhythmias (SVAs) after coronary artery bypass graft surgery (CABG). Randomized control trials were included if the electrocardiographic monitoring technique was clea…

Evidence of the potential impact of intravenous thrombolytic therapy on short-term revascularization rates among patients with acute myocardial infarction was sought. Because nonrandomized comparisons with conventional treatment would be subject to various confounders, a meta-analysis of randomized controlled trials wa…

This article reports the results of a meta-analysis of the effectiveness of antiarrhythmic drugs for the suppression of ventricular ectopic depolarizations. We analyzed 97 published articles that referred to a total of 27 drugs and contained data from 2989 patient-treatment trials; our goal was to determine the number…

Knee dislocation is an uncommon orthopedic diagnosis with a high rate of neurovascular complications. The goal of definitive management is to provide a pain free and functional knee through restoration of ligamentous stability and range of motion. Operative management has been suggested to be superior to nonoperative m…

INTRODUCTION: Bias and precision statistics have succeeded regression analysis when measurement techniques are compared. However, when applied to cardiac output measurements, inconsistencies occur in reporting the results of this form of analysis. METHODS: A MEDLINE search was performed, dating from 1986. Studies comp…

The metaanalysis can be either understood as a confirmatory analysis, i.e., imposing a requirement for reproducibility, or it can be rated as a descriptive analysis. To derive confirmatory statements from the statistical metaanalysis of comparative studies, the same requirements prevail as for every individual clinical…

BACKGROUND: Cardiovascular disease remains the leading cause of mortality worldwide, with residual cardiovascular (CVS) risk remaining high despite pharmacological interventions. Cholesteryl ester transfer protein (CETP) inhibitors have shown promise in improving lipid profiles, but their comparative effectiveness in r…

BACKGROUND: Bipolar disorder (BD) is a chronic mental illness that requires lifelong treatment. We investigated the comparative efficacy and safety of pharmacological interventions for bipolar maintenance, considering dose effects across different age groups. METHODS: We conducted a network meta-analysis (NMA) of rand…

Study designNetwork Meta-Analysis.ObjectiveTo comprehensively compare the clinical efficacy and safety of anterior controllable antedisplacement and fusion (ACAF), anterior cervical corpectomy and fusion (ACCF), and laminoplasty (LP) for treating multilevel cervical ossification of the posterior longitudinal ligament (…