44,649 papers found

BACKGROUND: With improving survival in breast cancer, supportive care has increasingly focused on long-term, treatment-related symptom clusters (e.g., pain, fatigue, vasomotor symptoms, insomnia, and anxiety) that impair quality of life and adherence. Within integrative oncology, non-pharmacological Traditional Chinese…

BACKGROUND: As the global demand for hip and knee arthroplasty procedures grow, advancements in orthopedic research are vital for progress. Pilot and feasibility trials play a critical role in optimising research efficiency, highlighting methodological gaps, and maximising study insights. However, the completeness of r…

BACKGROUND: Unhealthy lifestyles are associated with gut microbiota dysbiosis through complex inflammatory and immune-related pathways. Despite extensive primary research, comprehensive big-data syntheses mapping this field remain limited. This study systematically analyzes the research landscape, related pathophysiolo…

BACKGROUND: HIV serodiscordant relationships, where one partner is HIV-positive and the other is HIV-negative, present unique challenges despite biomedical advances including U = U (Undetectable = Untransmittable). Effective interventions are crucial to support these couples in managing thei…

BACKGROUND: Pharmacology plays a central role in linking biomedical science concepts with their application in clinical practice across medical and healthcare education. Globally, the pharmacological curriculum has evolved, just like other disciplines, through the integration of case-based, problem-based, and hybrid te…

Opioids are commonly used to manage both acute and chronic pain by acting on opioid receptors in the central and peripheral nervous systems. However, concerns about their increasing prescription and misuse have emerged due to adverse effects, toxicity, and the global impact of opioid-related harm.This systematic review…

BACKGROUND: Radiotherapy is a well-recognized risk factor of acute leakage after colorectal surgery. However, its relationship with delayed leakage remains unclear. The aim of this systemic review and meta-analysis was to determine its association with delayed anastomotic leakage (DAL) after rectal surgery. METHODS: A…

BACKGROUND: Musculoskeletal disorders (MSDs) significantly impact quality of life, particularly among Black, Asian, and Minority Ethnic communities in the UK, who face disproportionate burdens and barriers to care. Despite growing recognition of ethnic health disparities, there is limited understanding of interventions…

Early cancer detection and innovative treatments have prolonged the lifespan of cancer patients, leading to long-term consequences, including cancer-related cognitive impairment (CRCI). In 2011, the International Cancer and Cognition Task Force (ICCTF) established guidelines for neuropsychological assessment, however m…

BACKGROUND: Endoscopic ultrasound (EUS) has evolved from a diagnostic tool to a management technique for various gastroenterological conditions, including biliary strictures. AIM: To summarize the current evidence on EUS's role in diagnosing and managing biliary strictures. METHODS: Two independent reviewers searched…

INTRODUCTION: Systemic lupus erythematosus (SLE) is a chronic and complex multisystem autoimmune disease with high mortality. Telitacicept is a new strategy for the treatment of SLE, inhibiting the maturity, proliferation and differentiation of B cells, and thus, reduces disease activity. However, the effectiveness and…

BACKGROUND: Glaucoma is a leading cause of blindness globally, with emerging research suggesting that glaucoma-related degeneration may affect the visual pathway. Recent advancements in magnetic resonance imaging (MRI) offer promising non-invasive methods for evaluating glaucoma, including advanced diffusion MRI (dMRI)…

Crohn's disease (CD) and ulcerative colitis (UC) are two forms of inflammatory bowel disease (IBD). This chronic, immune-mediated disorder leads to inflammation in specific gastrointestinal tract regions. Myocarditis is a rare but significant IBD complication that affects roughly 0.3% of cases. Mesalazine-induced myoca…

BACKGROUND: Oxytocin has received considerable research attention for its role in affiliative behaviors, particularly regarding its pro-social effects. More recent evidence has pointed to a broader role of oxytocin signaling, which includes non-social cognitive processes. However, meta-analytic data on oxytocin's effec…

BACKGROUND: Aquatic activities are becoming increasingly popular as a form of exercise during pregnancy. However, the effects of these activities on the physical and mental health outcomes of pregnant women during and after pregnancy as well as fetal outcomes remain unclear. This meta-analysis evaluated the current evi…

This review aimed to systematically compare and pool the prevalence of all the known evidence on caregiver hesitancy and to describe the factors influencing vaccine hesitancy among caregiver worldwide such as COVID-19, MMR, Influenza, HPV and others. We searched article from few electronic databases (PubMed, CENTRAL, P…

Non-communicable diseases (NCDs) represent a high burden for the society and affected individuals. Conservative non-pharmacological interventions play a first-line role in the treatment and management of most NCDs. Systematic reviews (SRs) provide the highest level of evidence and significantly influence clinical decis…

The objective of this review was to evaluate the efficacy and safety of propofol in the treatment of critically ill patients diagnosed with alcohol withdrawal syndrome (AWS). A review was conducted in accordance with the PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-Analyses) criteria, and Embase, M…

BACKGROUND: Vibration platforms have demonstrated systemic effects generated by the use of mechanical vibrations, which are similar to those of any physical activity. The effect that whole body vibration (WBV) generates on the organism could be recommended in Diabetes Mellitus 2 (DM 2) patients. OBJECTIVE: To systemat…

Disorders linked to increased body weight are on the rise and obesity is a global epidemic associated with a rising risk for developing comorbidities, such as hypertension or type 2 diabetes. There is a significant need to develop a multimodal approach targeting obesity within clinical medicine. Pharmacological options…