44,649 papers found

Selective serotonin reuptake inhibitors (SSRIs) are first-line pharmacotherapy for mood and anxiety disorders. The common mechanism of drugs in this class is antagonism of the serotonin transporter. Within the serotonin transporter gene SLC6A4, two polymorphic sites termed 5-HTTLPR and STin2 are proposed to have functi…

Interleukin-4 (IL-4) polymorphisms have been reported to influence an individual's susceptibility to liver disease as it is a central anti-inflammatory Th2 cytokine; however, these results remain controversial.A comprehensive meta-analysis of the relevant literature was thus performed to better estimate the relationshi…

BACKGROUND: Studies on the association between obesity and ovarian cancer survival have had conflicting results. We reviewed and quantitatively summarized the existing evidence, exploring potentially important sources of variability, such as the timing of body mass index (BMI) assessment, BMI cut points, references use…

To determine which statin will better improve the apolipoprotein (Apo) profiles (ApoA-I levels, ApoB levels, and ApoB/A-I ratios), we performed a meta-analysis of randomized head-to-head trials of rosuvastatin versus atorvastatin therapy. MEDLINE, EMBASE, and the Cochrane Central Register of Controlled Trials were sear…

OBJECTIVE: To analyze alcohol and tobacco use among Brazilian adolescents and identify higher-risk subgroups. METHODS: A systematic review of the literature was conducted. Searches were performed using four databases (LILACS, MEDLINE /PubMed, Web of Science, and Google Scholar), specialized websites and the references…

OBJECTIVES: Orthodontic treatment can be associated with pain, particularly during separator placement, appliance insertion, or activation. Topical anesthetics may offer a simple, locally applied alternative to systemic analgesics, but their effectiveness remains uncertain. The objective of this review was to evaluate…

OBJECTIVES: To evaluate the effectiveness of telemonitoring on clinical outcomes in adult patients with heart failure, with an emphasis on treatment adherence, mortality, and hospital readmission, through a systematic review and meta-analysis of randomized clinical trials. METHODS: This is a systematic review protocol…

: Bone metastasis is one of the most common manifestations of advanced malignancy and a major cause of morbidity, particularly when involving the spine. Magnetic resonance imaging (MRI) plays a central role in its detection and characterisation due to its high sensitivity for bone marrow infiltration. However, bone met…

BACKGROUND: Atrial fibrillation (AF) recurrence after catheter ablation remains common and difficult to predict using conventional clinical risk models. Circulating biomarkers reflecting inflammation, myocardial remodeling, metabolic dysfunction, and neurohormonal activation may improve risk stratification. This system…

Sensorineural hearing loss, affecting over 1.5 billion people worldwide, results largely from irreversible damage to inner ear hair cells-specialized mechanosensory receptor cells that mammals cannot spontaneously regenerate. While recent advances in gene therapy and stem cell biology have raised hopes for biological r…

BACKGROUND: Recurrence of atrial fibrillation (AF) following catheter ablation is a major clinical problem, and there is considerable variability in patient outcomes. The identification of reliable predictors of AF recurrence is critical in developing patient management strategies. OBJECTIVE: To systematically identif…

BACKGROUND: Acute post-cesarean section (C/S) pain causes adverse maternal outcomes, and multimodal opioid-sparing analgesia is central to Enhanced Recovery after Surgery (ERAS) protocols. Quadratus lumborum block (QLB) is a promising regional technique, but evidence comparing it with other regional blocks remains frag…

Papillary thyroid cancer (PTC) is the most prevalent endocrine malignancy, accounting for over 90% of thyroid cancers. While differentiated thyroid cancers (DTCs) typically have favorable outcomes, a significant subset progresses to radioactive iodine-refractory (RAIR) disease, characterized by impaired iodine uptake a…

BACKGROUND: Primary malignant brain tumors (PBT) impose substantial burdens on patients and caregivers. Caregivers are essential in the delivery of outpatient care for patients with PBT but experience high levels of fatigue, distress, and health decline. Although exercise is known to improve outcomes in cancer patients…

AIM: Omega-3 polyunsaturated fatty acids (PUFA) possess anti-inflammatory and pro-resolving properties, suggesting potential benefits as adjuncts to non-surgical periodontal therapy (NSPT). This systematic review and meta-analysis aimed to evaluate the clinical efficacy of Omega-3 PUFA supplementation, with or without…

BACKGROUND AND AIM: Superficial musculoaponeurotic system (SMAS) rhytidectomy techniques are widely used in facelift surgery to achieve long-lasting facial rejuvenation. Nonetheless, variations in technique lead to differences in complication rates, aesthetic outcomes, and longevity of results. Current literature lacks…

BACKGROUND AND PURPOSE: Auriculotherapy for cancer-related fatigue has been investigated in various clinical trials; nonetheless, their conclusions remain inconsistent. In this systematic review and meta-analysis, the efficacy and safety of auriculotherapy for cancer-related fatigue were investigated. METHODS: Randomi…

PURPOSE: Individuals with advanced dementia often endure high symptom burden and receive limited specialized palliative care. Nurses play a central role in delivering end-of-life care, yet the impact of nurse-led interventions remains underexplored. This review synthesizes available evidence on nursing-led approaches,…

BACKGROUND: Mobile health (mHealth) technology is widely used in health care systems globally to improve patients' quality of life and reduce the burden on caregivers. Mobile apps allow users to manage different health-related situations from their homes, such as self-monitoring their symptoms, keeping track of progres…

INTRODUCTION AND AIMS: Denture biofilm is associated with various oral and systemic diseases. Therefore, an effective denture-cleaning method should be adopted by denture wearers. This systematic review aimed to evaluate the efficacy of ultrasonic denture cleaning in reducing plaque quantity and microbial load and chan…