Searching PubMed for “Clinical Trial” and checking full-text availability…
for “Clinical Trial” · Showing 8,121–8,140 · 1521 ms
Simpson M R, Simpson N R, Scott B O, +1 more·Annals of physical medicine
Abstract not available
LeBlanc Michael, Moon James, Crowley John·Biometrics
We construct interpretable prognostic rules based on a sequence of "box-shaped" regions in the predictor space indexed by the fraction of patients in the prognostic group. In addition, the method can be used as a building block to construct more general prognostic rules based on unions of boxes, or even as a tool to fi…
Gillis Anne M, PA3 clinical trial·Cardiac electrophysiology review
The optimal pacing mode for patients with paroxysmal atrial fibrillation (AF) following AV junction ablation remains the subject of some debate. Recent clinical trials have not demonstrated a superior advantage of maintenance of sinus rhythm over the rate control approach. However, clinical trials in pacemaker populati…
Hallander H O, Paniagua M, Espinoza F, +4 more·Vaccine
Serum responses to oral cholera vaccines were assessed in three paediatric vaccine trials, two in León, Nicaragua and one in Stockholm, Sweden. A calibrated anti-cholera toxin B subunit (CTB) IgA ELISA was used together with an assay for vibriocidal antibodies. Swedish children had lower pre-vaccination levels of…
van der Heijde D M, van Riel P L, Nuver-Zwart I H, +1 more·The Journal of rheumatology
Radiographic data of a 48-week double-blind, randomized, parallel trial comparing hydroxychloroquine (HCQ) and sulfasalazine (SASP) and its open label extension to 3 years of follow-up are analyzed in various ways. The focus of the paper is the methodological issues involved in analyses of radiographic data in a trial.…
Tangrea J A, Adrianza M E, Helsel W E·Annals of epidemiology
In this report, we examine the potential risk factors for both the incidence and the number of placebo adverse reactions among patients who were enrolled in the placebo control group in a multicenter clinical trial (n = 491). Of the nine baseline covariates analyzed, only clinical center was significantly related to bo…
Lennon M A, Worthington H V, Coventry P, +2 more·British dental journal
The results of a 3-year parallel, controlled clinical trial comparing a capitation system of payment for the dental care of children with fee-for-service, showed that capitation offered dentists more clinical freedom. Dentists in capitation used this to provide more preventive care, particularly advice to parents on th…
Armentia-Medina A, Blanco-Quiros A, Martin-Santos J M, +4 more·Annals of allergy
We carried out a double-blind clinical trial in 30 patients who were sensitized to Bermuda grass pollen. Before and after immunotherapy we performed in vivo tests (skin tests and standardized tests of specific and nonspecific bronchial hyperreactivity), in vitro tests (histamine release), and specific IgE and IgG antib…
Kaarela K, Lehtinen K, Skinhøj A, +1 more·Current medical research and opinion
In a double-blind, crossover trial a controlled-release multiple-units indomethacin formulation (50 mg twice daily) was compared with conventional capsules (25 mg twice daily with 50 mg in the evening) in 12 young and 18 elderly in-patients with rheumatoid arthritis. Earlier findings that younger patients preferred a s…
Haffejee I E·Annals of tropical paediatrics
In a prospective, controlled, randomized single-blind clinical trial, treatment with cefotaxime (CTX) was compared with that with standard therapy (ST), which consisted of a penicillin-chloramphenicol combination with or without sulphadiazine, in 31 patients (excluding neonates) with proven bacterial meningitis. The tw…
Matucci-Cerinic M, Casini A·International journal of clinical pharmacology research
The efficacy and safety of topical application of ketoprofen gel and etofenamate gel were studied in a controlled double-blind clinical trial. Thirty-six patients affected by inflammation of tendons, sheaths and bursae entered the study, and were treated for seven days. The parameters studied were: pain scale, Ritchie…
Moran K T, McEntee G, Jones B, +3 more·Annals of the Royal College of Surgeons of England
The effect of subcutaneous catheter tunnelling on the incidence of catheter sepsis and on catheter life span in the absence of a nutrition team was determined in a prospective controlled clinical trial. Eighty one patients who received 92 courses of parenteral nutrition had 110 catheters inserted. Alternate catheters w…
Haverkorn M J·The Journal of hospital infection
A multi-centre double-blind, placebo-controlled clinical trial was performed to determine the minimum number of doses of metronidazole required for effective prophylaxis of vaginal cuff abscess following hysterectomy. Four hundred and seventy-five patients received zero, one, two, three, six or twenty-one 500 mg doses…
Lowenthal D T, Saris S, Paran E, +4 more·American heart journal
Worldwide clinical trial data concerning the pharmacokinetic and pharmacodynamic characteristics of the clonidine transdermal therapeutic system (TTS) are reviewed with reference to its antihypertensive efficacy. The amount of clonidine delivered to the systemic circulation is a direct function of TTS size. After initi…
Laska E M, Sunshine A, Marrero I, +3 more·Clinical pharmacology and therapeutics
A clinical trial comparing ibuprofen, 400, 600, and 800 mg, with aluminum ibuprofen, 400 mg, and placebo was conducted in patients with moderate or severe pain subsequent to third molar extraction. Pain intensity ratings and ibuprofen serum levels were obtained at baseline, 30 minutes, 1 hour, and hourly thereafter for…
Varsano I, Volovitz B, Mimouni F·American journal of diseases of children (1960)
The efficacy of sulfisoxazole prophylaxis was evaluated in 32 otitis-prone children in a double-blind cross-over clinical trial. During the sulfisoxazole therapy, seven patients (22%) had nine episodes of acute otitis media (AOM) while 20 patients (63%) receiving placebo had 36 episodes of AOM (P = .001). Although sulf…
Belovezhdov N, Talakova Ch, Angelova I, +2 more·Vutreshni bolesti
A method was elaborated for clinical trial of pharmaceuticals for the treatment of infections of kidneys and urinary ducts. The main requirements are as follows: definitive diagnostic criteria for urological infection, monotherapy, systematic control for the drug intake, precisely formulated indices for assessment of t…
Taubman B·Pediatrics
A study evaluating the treatment of colic by modification of the parent-infant interaction was carried out in a private practice setting. The study population consisted of 30 normal colicky infants and 30 control infants matched for age in weeks, sex, and the presence of siblings. The two groups were similar with regar…
Creager M A, Pariser K M, Winston E M, +3 more·American heart journal
The effect of nifedipine on fingertip hemodynamics was studied in 10 patients with Raynaud's phenomenon. Fingertip blood flow (FBF) was determined in a 20 degrees C environment by venous occlusion air plethysmography and fingertip vascular resistance (FVR) was calculated from the mean blood pressure and the FBF. Nifedi…
Ojala A, Nikkanen V N, Paloheimo S, +2 more·Strahlentherapie
A controlled clinical trial was performed to test two different chemotherapy regimens (doxorubicin + cyclophosphamide + vincristine versus CCNU + vincristine) in 100 patients with metastatic or recurrent non-small cell bronchogenic carcinoma. There was no significant difference between treatment groups in survival or i…