1,558,173 papers found

A randomized prospective clinical trial of feeder vessel photocoagulation for proliferative sickle cell retinopathy was performed. In Chicago there were 34 argon laser-treated eyes and 30 control eyes. In Kingston there were 53 xenon arc treated eyes and 50 control eyes. Prolonged loss of visual acuity was rare in both…

The Senile Macular Degeneration Study (SMDS) is a multicenter controlled clinical trial designed to answer the question, "Is argon laser photocoagulation useful in preventing severe visual loss in eyes with evidence of senile macular degeneration and a choroidal neovascular membrane outside the fovea?" Eligible patient…

An early clinical trial of pentamethylmelamine (PMM) the monodemethylated derivative of hexamethylmelamine, was conducted in 22 adults with solid tumors. PMM was administered as a 2-hour iv infusion every 4 weeks at doses ranging from 40 to 2400 mg/m2. A combination of gastrointestinal and neurologic (CNS) toxicity was…

The present status of 38 patients comprising a clinical trial of jejunoileal and gastric bypass for the treatment of morbid obesity, begun four years ago at North Carolina Memorial Hospital, is reported. Weight loss was greater in patients treated by jejunoileal bypass than those treated by gastric bypass. The poorer w…

In a controlled, randomized prospective clinical trial the utility of intravenous hyperalimentation (IVH) in the administration of and tolerance to chemotherapy was tested. The conclusions reached were 1) IVH is safe with a tolerable infection rate; 2) infectious complications correlate significantly with the nutrition…

A clinical trial of chemoimmunotherapy using cell-wall skeleton of BCG (BCG-CWS) was conducted in 28 patients with acute leukemia in complete remission. Chemotherapy consisted of monthly intensification therapy for 2 months and bimonthly therafter. Immunotherapy with 200 microgram of oil-attached BCG-CWS mixed with 10(…

In a double-blind crossover trial of two 12-week treatment periods with a 4-week treatment free interval, to which 21 patients were admitted, there was no statistically significant difference between clonidine 75 microgram twice daily and placebo in the total number of headache days, migraine indices, duration of attac…

The "R-75" strain live, attenuated, serum inhibitor-resistant influenza B vaccine was administered intranasally by drops in two doses 14 days apart to 21 volunteers. Each vaccinee was paired with a close associate (roommate or workmate) who similarly received two doses of a placebo solution. Although about 50% of both…

A comparison has been made of the relapse rates between 7 and 30 months for four 6-month regimens. Streptomycin plus isoniazid plus rifampicin had a relapse rate of 2 per cent of 171 patients; isoniazid plus rifampicin had a relapse rate of 7 per cent of 164. An initial 2 months of streptomycin, isoniazid, rifampicin,…

Therapeutic effects of prochlorperazine and betahistine on patients with confirmed Meniere's disease (range of duration 1-11 years) were compared in a double-blind cross-over trial. The two active treatment periods lasted 4 montsh each, separated by a single blind "wash-out" period of 1 month's duration. Out of 30 pati…

In a controlled clinical investigation based on ten patients with simple absences and ten patients with myoclonic atonic seizures, all patients who had insufficient response to conventional antiepileptic treatment received clonazepam (Rivotril [Denmark]; Clonopin, comparable US product) combined with previous antiepile…

A clinical trial was undertaken to compare the efficacy of neutral red photodynamic inactivation treatment of genital herpes infections with that of a non-photoactive dye, phenol red, as a control. In a series of nineteen patients with virologically proven herpes genitalis who were adequately followed, eleven were trea…

PURPOSE: We performed a phase 2 randomized clinical trial to evaluate the preliminary effectiveness of a clinic-based patellar mobilization therapy (PMT) in patients with knee osteoarthritis. METHODS: We recruited 208 patients with knee osteoarthritis at primary care clinics in Hong Kong. Patients were randomly assign…

A clinical trial of 21 cases was conducted to evaluate the effects of a pulsed magnetic field on pseudoarthroses. Nineteen out of 21 cases had successful results; the remaining 2 failed to respond. Two-coiled and four-coiled systems were used in this study. It was concluded that the four coiled system is more effective…

The paper analyses the results of intravascular therapy by contrykal (10 patients) and hydrocortisone (10 patients) in juvenile rheumatoid arthritis. High efficacy of treatment by contrykal was noted.

The effect of hemodilution was studied in 106 acute ischaemic stroke patients (55 hemodiluted and 51 control subjects). The investigation did not show statistically significant differences between the two groups regarding the mortality rate and the degree of rehabilitation (modified Rankin Scale) but revealed a signifi…

"Growing pains" is a benign clinical entity of unknown etiology. This study examines a muscle stretching treatment based on a theory that the etiology of these pains is related to fatigue. The experimental group (18 children) showed a more rapid resolution of their symptoms over an 18 month period when compared to the…