44,648 papers found

Idiopathic pulmonary fibrosis (IPF) is a progressive disease with a poor prognosis. A number of studies reported the association between MUC5B promoter polymorphism rs35705950 and IPF, but substantial inconsistent findings were observed and the strength of association remains unclear.The aim of the study was to investi…

OBJECTIVE: This study informs efforts to improve the discoverability of and access to biomedical datasets by providing a preliminary estimate of the number and type of datasets generated annually by research funded by the U.S. National Institutes of Health (NIH). It focuses on those datasets that are "invisible" or not…

BACKGROUND: In order to better monitor non-alcoholic fatty liver disease (NAFLD) patients at higher risk for HCC, there is a need for non-invasive diagnostic approaches to screen for the presence of advanced fibrosis in these patients. The aim of this systematic review and meta-analysis will be to evaluate the diagnost…

BACKGROUND: Despite the established causal relationship between tobacco smoking and cancer, many cancer patients continue to smoke after diagnosis. This partly reflects ignorance of the beneficial effects of smoking cessation, even after diagnosis. The aim of this study was to demonstrate the effects of continuing or q…

To determine whether off-pump coronary artery bypass grafting (CABG) increases mid-term major adverse cardiovascular (and cerebrovascular) events MACCE over on-pump CABG, we performed a meta-analysis of exclusive large randomized controlled trials (RCTs). Databases including MEDLINE, EMBASE and the Cochrane Central Reg…

BACKGROUND: Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN) are rare severe cutaneous drug reactions. No large scale epidemiological data are available for this disorder in India. AIMS: To carry out a systematic review of the published evidence of the drug-induced SJS and TEN in Indian population.…

Tourette syndrome (TS) is a heritable disorder characterized by tics that are decreased in some patients by treatment with alpha adrenergic agonists and dopamine receptor blockers. Thus, this study examines the relationship between catecholamine gene expression in blood and tic severity. TS diagnosis was confirmed usin…

BACKGROUND: The majority of patients with type 2 diabetes mellitus (T2DM) are overweight or obese. Obesity is a significant risk factor for increased morbidity and mortality in people with T2DM, and increased weight has been shown to worsen glycemic control and increase the risk of diabetes progression. METHODS: A sea…

BACKGROUND: Rhytidectomy is one of the most performed facial rejuvenation procedures, yet postoperative hematoma remains its most frequent and consequential complication, driving patient morbidity and compromising aesthetic outcomes. Tranexamic acid (TXA), a potent antifibrinolytic agent, has been widely adopted to mit…

INTRODUCTION: Stimulant use disorder (StUD), including cocaine and methamphetamine use disorders, remains a major unmet clinical need with no approved pharmacotherapies. Despite strong mechanistic rationale, dopamine transporter (DAT)-directed strategies have largely failed to translate into consistent clinical benefit…

BACKGROUND: Climate change poses significant threats to human health, necessitating the integration of environmental protection into public health efforts. Planetary health education (PHE) represents an emerging paradigm connecting human well-being with natural systems; however, its global implementation remains inadeq…

The role of solid-food diets in managing Crohn disease (CD) is gaining increasing attention in the scientific research community, while current evidence is limited and consists of highly heterogenous methodologies. In this scoping review we aimed to provide a comprehensive analysis of the most important methodological…

BACKGROUND AND AIMS: The use of supraglottic airway devices (SGADs) is still controversial in paediatric otorhinolaryngological surgeries. We conducted this review and analysis to compare SGADs to endotracheal tubes (ETTs) regarding the feasibility of their use in children. METHODS: Randomised controlled trials (RCTs)…

Scarring frequently lowers quality of life and can have both functional and aesthetic impacts. Recently it has been debated whether platelet-rich plasma (PRP) can be used as a therapy modality for improving scar outcomes, given its abundance of cytokines and growth factors. This study attempts to methodically assess PR…

The N-methyl-D-aspartate (NMDA) receptor plays a pivotal role in pain modulation, making it a key target for therapeutic interventions in chronic pain management. Traditionally known for its cognitive-enhancing effects, piracetam (2-oxo-1-pyrrolidine acetamide) has shown promise in influencing glutamatergic transmissio…

Sustained ventricular tachycardia (VT) and fibrillation-related sudden cardiac death account for nearly 450,000 deaths annually in the United States. Catheter ablation (CA) and antiarrhythmic drugs (AADs) are commonly used to manage VT recurrence; however, their comparative efficacy and safety remain uncertain. We cond…

AIM: To conceptualize nursing education and care by evaluating hard and soft skills during training and professional practice, synthesize existing definitions and assessment strategies of soft skills. BACKGROUND: The nursing discipline is made up of a theoretical and practical framework, which is increasingly technica…

BACKGROUND: In this study, we aim to evaluate the effects of hyaluronic acid and its derivatives on wound healing in diabetic foot ulcer. METHODS: The electronic databases included PubMed, BIOSIS, EMBASE, Cochrane Central Register of Controlled Trials (CENTRAL), and Google Scholar internet. The final search was update…

Primary surgery in metastatic breast cancer (MBC) has been a subject of debate in part due to the heterogeneity of the results of individual studies. We synthesized evidence from the existing randomized clinical trials (RCTs) to evaluate the effect of primary surgery on health-related quality of life (HRQoL) in MBC.We…

BACKGROUND: Chickpeas are a legume that may help improve glycemic control, but their acute effects on postprandial glucose and insulin responses are unclear. This systematic review and meta-analysis aimed to assess the impact of acute chickpea consumption on these outcomes in controlled, crossover trials. METHODS: We…