1,558,173 papers found

Double blind controlled study on fifty treatment-resistant schizophrenic inpatients showed a statistically significant improvement in favour of the high dose group.

The anticholinergic effect of trihexphenidyl on memory function of 20 schizophrenic patients has been investigated in a double blind crossover design. Impairment of immediate memory and short term memory was evident after trihexphenidyl treatment in comparison with placebo. Sensory short term memory tested by visual ta…

Nocturnal asthma is a common and potentially dangerous condition. The mechanisms in its production are multifactorial. One factor appears to be increased vagal tone at night so that an anticholinergic drug might prove effective. The evidence for a bronchodilator action of anticholinergic drugs is reviewed. A clinical t…

Motrin (ibuprofen), a potent inhibitor of prostaglandin synthetase, was tested in women and men for treatment of recurrences of genital herpes. In a double-blind trial, no statistically significant differences were observed between treated and placebo groups in any of the measured parameters.

Fifty patients with extensive alopecia areata took part in a prolonged double blind trial to compare the effect of 1% minoxidil in unguentum merck with that of unguentum merck alone. There was no significant difference between the hair growth of patients treated with the placebo or with the active compound.

Twenty-one patients who presented to three sexually transmitted disease (STD) clinics in the south area of Los Angeles County were diagnosed to have anorectal or pharyngeal gonorrhea and gave a history of hypersensitivity of penicillin. Treatment with doxycycline, 300 mg initially, followed by 200 mg daily for six days…

Imipramine, phenelzine and alprazolam have each been shown to be efficacious in the treatment of panic disorder and in agoraphobia with panic attacks. Clonazepam, a 1,4 benzodiazepine derivative used mainly in neurology as an anti-epileptic, has specific pharmacodynamic and pharmacokinetic properties which would make i…

Thirty normal weight women with bulimia completed a double-blind, placebo-controlled trial of phenelzine sulfate. The results demonstrate a significant therapeutic advantage for phenelzine over placebo. Preliminary data suggest that phenelzine may be of benefit even to non-depressed patients with bulimia.

Piracetam has been described to improve neuroleptic-induced acute extrapyramidal syndrome where a central dopaminergic hyperactivity is implicated. In Huntington's chorea, this abnormality is also generally admitted, at least functionally. Therefore the authors have utilized piracetam in this disease. The drug was admi…

Forty six confirmed cases of polyneuritis were treated in a double-blind survey for 4 to 5 months. The results were evaluated in terms of clinical examinations and electrophysiological tests. There was a clearly significant difference in favour of isaxonin. Tolerance was good, in particular insofar as the liver was con…

The first investigation of iohexol in human cardioangiography is presented. Slight subjective reactions as well as moderate and transient influence on hemodynamics and ECG parameters were recorded. Analysis of serum enzymes indicated no myocardial injury. Good or excellent films of the left ventricle, aortic root and c…

All-night electroencephalographic (EEG) sleep studies were obtained before and during a double-blind clinical trial of hemodialysis in six schizophrenic patients with normal renal functioning. No significant changes were observed in either clinical status or sleep, except for a significant reduction in rapid eye moveme…