44,638 papers found

BACKGROUND: Fatigue is a common symptom in cancer patients receiving active treatment. There are a limited number of reviews evaluating interventions for fatigue during active treatment, and they are restricted to patients with advanced cancer, or to patients during radiotherapy. To date there is no systematic review o…

BACKGROUND: For almost one hundred years abdominoperineal excision has been the standard treatment of choice for rectal cancer. With advances in the techniques for rectal resection and anastomosis, anterior resection with preservation of the sphincter function has become the preferred treatment for rectal cancers, exce…

BACKGROUND: The effect of different concentrations of heparin-locking solution for central venous catheters (CVC) in hemodialysis patients is varied. Regarding the optimal concentration of heparin-locking solution, there is no definitive consensus based on evidence. OBJECTIVE: To investigate the efficacy and safety of…

BACKGROUND: Chronic neck pain is a common problem with a poorly understood pathophysiology. Often no underlying structural pathology can be found and radiological imaging findings are more related to age than to a patient's symptoms. Besides its common occurrence, chronic idiopathic neck pain is also very disabling wit…

BACKGROUND: Treatment of sleep disorders in visually impaired children is complicated by a complex pathophysiology, a high incidence of sleep disorders in this population, and a dearth of management options. The significant impact on the health of these children and distress to their caregivers warrant a systematic ass…

: Attention-deficit/hyperactivity disorder (ADHD) is associated with alterations in eating behavior, dietary patterns, and body weight regulation. Although pharmacological treatment is known to suppress appetite, its broader effects on nutrition-related outcomes remain unclear. This scoping review aimed to map the avai…

INTRODUCTION: Myasthenia gravis (MG) is an antibody-mediated autoimmune neuromuscular disorder for which long-term disease control remains challenging in some patients. Telitacicept, a dual inhibitor of B-cell activating factor (BAFF) and a proliferation-inducing ligand (APRIL), has been investigated as a potential the…

BACKGROUND: Across the world, many national sport systems make extensive strategic investments in talent promotion programs (TPPs). The most common TPPs include youth sport academies and sport federations' junior squads. The central idea of TPPs is (1) to select the most promising talents at young ages (around puberty…

INTRODUCTION: A patent processus vaginalis (PPV) is frequently observed during laparoscopic orchiopexy in infants with cryptorchidism. Nevertheless, the decision to primarily close the PPV following laparoscopic orchiopexy remains a subject of debate. This protocol therefore outlines the scope and methodology for a sys…

BACKGROUND: Older adults represent a growing and highly vulnerable intensive care unit (ICU) population due to geriatric syndromes, functional decline, and multimorbidity. These factors increase the complexity of care and require nursing interventions that support functional stability, prevent complications and ad…

BACKGROUND: Severe early childhood caries (s-ECC) remains a highly prevalent condition among children worldwide, posing a considerable burden in both developed and developing regions. This systematic review seeks to comprehensively identify, synthesize, and critically evaluate available evidence on salivary proteomic a…

This systematic review and meta-analysis aims to investigate the effect of heparin full-dose anticoagulation on preventing COVID-19 disease progression in non-critically ill COVID-19 adult patients in accordance with the Cochrane methodology and the Preferred Reporting for Systematic Reviews and Meta-Analyses (PRISMA)…

BACKGROUND: This systematic review aims to assess whether extending Alt-RAMEC (Alternating Rapid Maxillary Expansions and Constrictions) protocols from four to nine weeks yields superior skeletal, dental, and soft-tissue outcomes in growing noncleft Class III patients when compared to conventional rapid maxillary expan…

Ureteropelvic junction obstruction (UPJO) is a major cause of obstructive uropathy in pediatric patients. However, the optimal management remains controversial. We aimed to summarize the evidence comparing surgical versus conservative treatment. We searched MEDLINE/PubMed (2016 to 31 October 2024) and the Cochrane Cent…

The indications for deltoid ligament (DL) repair in ankle fractures are not well-defined. This meta-analysis aims to evaluate clinical, radiographical, and functional outcomes related to DL repair in ankle fractures. Following Cochrane and PRISMA guidelines, a comprehensive literature search was conducted across Cochra…

BACKGROUND: The clinical manifestations of 22q11.2 deletion syndrome (22q11.2 DS) are highly heterogeneous, and the underlying causes of phenotypic variation remain unclear. This study conducted a systematic meta-analysis to evaluate the impact of the deletion position within the 22q11.2 region on phenotypic variabilit…

PURPOSE: Maxillary sinus floor elevation is a safe and effective surgical technique for achieving vertical bone height, performed through either a lateral or crestal approach. The latter includes both the osteotome technique and osseodensification. The aim of this systematic review was to compare the outcomes of the cl…

RATIONALE: Although there is broad agreement that caffeine provides an acute improvement in attention in the normal population, estimates of effect size vary and the relationship between dose and effect is unclear. OBJECTIVE: To examine the acute effect of caffeine on attention in a systematic review and meta-analysis…

Gastrocolic fistula (GCF) is a rare but serious complication following metabolic bariatric surgery (MBS), primarily caused by leaks from the staple line or anastomotic sites. This systematic review aims to comprehensively analyze the diagnosis and management strategies for GCF following MBS. The Cochrane Central Regist…

Parkinson's Disease (PD) is a progressive neurodegenerative disorder characterized by motor impairments, including balance deficits, gait disturbances, and postural instability. Given the limitations of pharmacological treatments, alternative rehabilitative strategies such as Argentine Tango (AT) have been explored for…