42,240 papers found

BACKGROUND: Ulcerative colitis is a chronic inflammatory bowel disease. Corticosteroids and 5-aminosalicylates are the most commonly used therapies. However, many patients require immunosuppressive therapy when their disease becomes steroid-refractory or dependent. Methotrexate is a medication that is effective for tre…

OBJECTIVE: The objective was to evaluate the efficacy and safety of dexmedetomidine in the treatment and prophylaxis of paroxysmal sympathetic hyperactivity (PSH). DATA SOURCES: A review was conducted in accordance with the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) criteria and querie…

PURPOSE: To understand the use of soft liners/reliners in complete dentures to improve mastication, bite force, and patient's quality of life, and to reduce pain. METHODS: A systematic search was performed in MEDLINE (PubMed), EMBASE, and CENTRAL until May 2025 to find clinical studies comparing removable prostheses w…

BACKGROUND: Dengue is one of the common arboviral infections and is a public health problem in South East Asia. The aim of this systematic review and meta-analysis was to evaluate the prevalence and distribution of dengue in SAARC (South Asian Association for Regional Cooperation) countries. METHODS: The PubMed, PubMe…

BACKGROUND: This systematic review and network meta-analysis aimed to evaluate the three different administration routes of vitamin B12: oral, intramuscular (IM), and sublingual (SL) routes. METHODS: We searched four electronic databases (PubMed, Scopus, Web of Science, and Cochrane CENTRAL Register of Controlled Tria…

Sleep is controlled by homeostatic mechanisms, which drive sleep after wakefulness, and a circadian clock, which confers the 24-h rhythm of sleep. These processes interact with each other to control the timing of sleep in a daily cycle as well as following sleep deprivation. However, the mechanisms by which they intera…

BACKGROUND: Climate change poses significant threats to human health, necessitating the integration of environmental protection into public health efforts. Planetary health education (PHE) represents an emerging paradigm connecting human well-being with natural systems; however, its global implementation remains inadeq…

The role of solid-food diets in managing Crohn disease (CD) is gaining increasing attention in the scientific research community, while current evidence is limited and consists of highly heterogenous methodologies. In this scoping review we aimed to provide a comprehensive analysis of the most important methodological…

CONTEXT: Nicotine has been investigated in prior studies for its analgesic effects and its impact on postoperative nausea and vomiting (PONV), yet results have been inconsistent. OBJECTIVES: This systematic review and narrative synthesis evaluates the effects of perioperative nicotine administration on postoperative p…

Scarring frequently lowers quality of life and can have both functional and aesthetic impacts. Recently it has been debated whether platelet-rich plasma (PRP) can be used as a therapy modality for improving scar outcomes, given its abundance of cytokines and growth factors. This study attempts to methodically assess PR…

Sustained ventricular tachycardia (VT) and fibrillation-related sudden cardiac death account for nearly 450,000 deaths annually in the United States. Catheter ablation (CA) and antiarrhythmic drugs (AADs) are commonly used to manage VT recurrence; however, their comparative efficacy and safety remain uncertain. We cond…

AIM: To conceptualize nursing education and care by evaluating hard and soft skills during training and professional practice, synthesize existing definitions and assessment strategies of soft skills. BACKGROUND: The nursing discipline is made up of a theoretical and practical framework, which is increasingly technica…

Primary surgery in metastatic breast cancer (MBC) has been a subject of debate in part due to the heterogeneity of the results of individual studies. We synthesized evidence from the existing randomized clinical trials (RCTs) to evaluate the effect of primary surgery on health-related quality of life (HRQoL) in MBC.We…

TOPIC: Ocular comorbidities of psoriasis: A systematic review and meta-analysis of observational studies. DESIGN: Systematic review and meta-analysis. CLINICAL RELEVANCE: Ocular comorbidities of psoriasis have been raised with growing evidence. Certain eye diseases require prompt diagnosis and appropriate interventio…

BACKGROUND: Chickpeas are a legume that may help improve glycemic control, but their acute effects on postprandial glucose and insulin responses are unclear. This systematic review and meta-analysis aimed to assess the impact of acute chickpea consumption on these outcomes in controlled, crossover trials. METHODS: We…

OBJECTIVE: The current literature on abdominal aortic aneurysms (AAAs) is characterised by heterogeneous outcome reporting and lack of standardisation. Thus, a core outcome set (COS) for patients with intact AAA not undergoing repair is being developed. The disease course in these patients is uncertain; some may progre…

BACKGROUND: Pulmonary hypertension (PH) is defined as an increase in mean pulmonary arterial pressure, often accompanied by indicators such as dyspnea on exertion, exercise intolerance, and systemic muscle dysfunction. Various protocols exist that can indirectly assess these indicators through the sit-to-stand test (ST…

INTRODUCTION: Various physical therapy interventions for coccydynia have been evaluated, but their effectiveness has not yet been comprehensively synthesized. This systematic review aims to evaluate the effectiveness of physical therapy interventions in adults with coccydynia. METHODS: A systematic search of relevant…

BACKGROUND: Disinfectant sprays and wipes reduce the risk of infection from contaminated surfaces and materials in healthcare facilities. To support guideline updates, evidence on surface disinfection against the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection are needed. AIM: This study aims to…

OBJECTIVES: To ascertain the effects of prolonging flushing intervals (FIs) for Totally Implantable Venous Access Devices (TIVADs) on catheter-related complications in the off-treatment period. METHODS: A preliminary search of PubMed, EMBASE, Cochrane, Web of Science, Web of Science, Scopus, CNKI, and SinoMed was cond…