44,638 papers found

BACKGROUND: Non-alcoholic fatty liver disease (NAFLD) is becoming a wide spread liver disease. The present recommendations for treatment are not evidence-based. Some of them are various weight reduction measures with diet, exercise, drug, or surgical therapy. OBJECTIVES: To assess the benefits and harms of intended we…

BACKGROUND: Activity limitations of the upper extremity are a common finding for individuals living with stroke. Mental practice (MP) is a training method that uses cognitive rehearsal of activities to improve performance of those activities. OBJECTIVES: To determine if MP improves the outcome of upper extremity rehab…

BACKGROUND AND OBJECTIVE: Malignant grade and death rate are very high for non-small cell lung cancer, and gefitinib is a new molecule target anticancer drug. The aim of this meta analysis is to evaluate the clinical efficacy and safety of gefitinib for non-small cell lung cancer. METHODS: We searched the Cochrane Cen…

BACKGROUND: Research on the clinical application of oral naltrexone agrees on several things. From a pharmacological perspective, naltrexone works. From an applied perspective, however, the medication compliance and the retention rates are very poor. OBJECTIVES: To evaluate the effects of naltrexone maintenance treatm…

BACKGROUND: Continuous infusions of the intravenous anaesthetic propofol are commonly used to induce and maintain sedation and general anaesthesia. Infusion devices can be manually controlled (MCI) where the anaesthetist makes each change to the infusion rate or target-controlled (TCI) where the anaesthetist sets a tar…

BACKGROUND: For almost one hundred years abdominoperineal excision has been the standard treatment of choice for rectal cancer. With advances in the techniques for rectal resection and anastomosis, anterior resection with preservation of the sphincter function has become the preferred treatment for rectal cancers, exce…

Posterior-canal benign paroxysmal positional vertigo is commonly treated with canalith repositioning maneuvers or habituation exercises. Epley-type maneuvers may provide faster symptom and nystagmus resolution than Brandt-Daroff exercises, but comparative effects on recurrence, functional outcomes, and adverse events r…

BACKGROUND: The cardiovascular safety of testosterone replacement therapy (TRT) in older men with hypogonadism has been debated for over a decade, largely on the basis of underpowered trials and conflicting observational data. The TRAVERSE trial, published in 2023, provided the first adequately powered, placebo-control…

Cardiac erosion after transcatheter closure of secundum atrial septal defect (ASD) is a rare (0.1-0.3%) but potentially life-threatening complication. Available evidence remains limited to isolated case reports and small case series.A case-based review was conducted in accordance with CABARET recommendations. PubMed, S…

BACKGROUND: Obesity is a complex chronic disease involving genetic, environmental, and behavioral factors. Traditional Chinese medicine (TCM) non-pharmacological therapies are promising complementary strategies for simple obesity, yet evidence is fragmented and their comparative effectiveness remains unclear. OBJECTIV…

() infection has been extensively studied for its potential association with irritable bowel syndrome (IBS), with prior meta-analyses reporting inconsistent findings. This study aimed to perform a systematic review and meta-analysis of observational studies restricted to those providing reconstructable 2×2 conting…

PURPOSE: Tension band fixation (TBF) using screws or wires is the widely accepted standard of care for patellar fractures. This meta-analysis aims to quantitatively compare postoperative outcomes between Kirschner wire tension band fixation (KWTB) and cannulated screw tension band fixation (CSTB) to determine the optim…

BACKGROUND: Artificial intelligence (AI)-assisted three-dimensional (3D) surgical platforms, integrated with augmented reality, have the potential to improve intraoperative anatomical recognition and provide surgeons with an immersive, dynamic operating environment during uro-oncological procedures. This review aims to…

INTRODUCTION: One of the challenges in managing patients with hantavirus infection is accurately identifying individuals who are at risk of developing severe disease. Prompt identification of these patients can facilitate critical decisions, such as early referral to an intensive care unit. The identified prognostic fa…

Subfascial placement has been reported to reduce capsular contracture (CC) in primary breast augmentation. Given the shift toward smooth implants, it is unclear whether the perceived advantage reflects the surgical plane or historical implant selection. This study compares CC rates between subfascial and subglandular b…

Malocclusion is one of the most significant dental issues that interferes with daily life activities. However, direct comparison between orthodontic treatment with clear aligners (CAs) and fixed aligners (FAs) is not yet established. We aimed to assess the impact of CA versus FA in patients with malocclusion. We s…

Ulcerative colitis (UC) significantly affects patients' lives, and treatment options may be constrained due to severe side effects. Vedolizumab, a monoclonal antibody that specifically targets the α4β7 integrin, has recently demonstrated potential as a gut-specific therapy with fewer adverse effects compare…

Heart failure remains a leading global health burden affecting over 64 million individuals worldwide, with limited effective acute management strategies. Carperitide, a recombinant form of human atrial natriuretic peptide, has been primarily used in Japan for acute heart failure treatment, but its clinical efficacy rem…

BACKGROUND: This study seeks to evaluate the comparative effectiveness of various physical activity modalities: including aerobic (AT), resistance (RT), flexibility (FT), and combined aerobic-resistance (AT + RT) training, in reducing depressive symptoms among children and adolescents, with the aim of det…