98,302 papers found

Peroxisome proliferator activated receptors (PPARs) are fertile targets for drug discovery. They are targets for two widely used classes of drugs, the fibrates and thiazolidinediones. Remarkable advances have been made in our understanding of the mechanism of action of these receptors over the last 10 years. Further re…

In this essay with a flavor of science history, the influence of imaging techniques, as compared to other research strategies, on microbiologic investigations is discussed. Using a few selected examples, to what degree microbiology became a leading science during the last 50 years in gaining knowledge in life sciences,…

In last month's issue, in Part I, we described the experiences of three New Orleans, LA, hospitals in preparing for and coping with one of the worst potential storms in years. As will be seen, each of the three hospitals featured in Part II faced problems that were both foreseen and unforeseen--some of which required c…

The average spermatozoa concentration in the ejaculate fell progressive even if sharply in the last 50 years. The azoospermia, described as the complete spermatozoa absence in the sperm, has a variable incidence between 10 and 20% in the clinical picture of the male infertility. The authors outline an etiological class…

The four IgG subclasses differ with respect to structure and biological function. Within the last 26 years, numerous immunological methods have been developed to study the role of the individual subclasses in humoral immune response. Different methods for quantitative IgG-subclass determinations are discussed with spec…

We give a survey of the latest developments in dermatovirology. The actual epidemiologic situation is described with special reference to the increasing incidences of AIDS, condylomata acuminata, mollusca contagiosa, and herpes simplex type 2. The dermatovirological progress achieved during the last few years is mostly…

Radiological study of bone sarcomas has been improved for the last ten years. Standard X-ray analysis is now more precise. CT and MRI are presently playing an important role for pretreatment local evaluation, assessment of treatment effectiveness and detection of recurrences.

A simplified technique for treatment of pilonidal sinus has been employed in 25 patients during the last 3 years. Initial results have been very encouraging as there have been no recurrences up to the present time. Mean duration of hospitalization was 3 days, patients can get out of bed after 24 hours, and work can be…

For the last 20 years many varieties of suturing instruments for different branches of surgery have been designed. The main trend in the design of suturing instruments is the use of plate matrices, when the tissue to be sutured is placed between the matrix and the stapling part, as well as the use of needle-shaped matr…

The discoveries made by academic immunologists must be examined for their possible clinical value, and every few years an in-vitro test applicable to patients is seized upon with particular enthusiasm. Some become laboratory investigations routinely ordered by clinicians, while others fall by the wayside. In the last d…

A bibliography of behavioral research on severe and profound mental retardation was presented and briefly summarized. The review documented a dramatic shift in thinking about this population that has occurred in the last 20 years.

Primary Gastrointestinal Angiosarcoma (PGAS) constitutes a rare malignant tumor arising from vascular or lymphatic endothelial cells. The aim of this study was to review the available literature on PGAS and to elucidate its biological behavior and optimal therapeutic approach. PubMed and Embase bibliographical database…

AIM: The aim of this study was to report on the severity and incidence of children injured by treadmills and to promote the implementation of safety standards. METHOD: This retrospective review of children with treadmill friction injuries was conducted in a single tertiary-level burns centre in Australia between Janua…

Of 846 adolescents interviewed near their 15th birthday, 51% could drive a motorcycle. A further 13% intended to learn. Drivers reported friends (mean age 16.5 years) as the most common source of instruction. Forty-four per cent of drivers and 69% of intending learners planned to apply for licences. Thirty-five per cen…

INTRODUCTION: In Romania, no nationwide data for acromegaly treatment and control rate are available. Our objective was to assess the acromegaly control rate in a tertiary referral centre, which covers an important part of Romanian territory and population of patients with acromegaly. MATERIALS AND METHODS: We reviewe…

AIMS AND BACKGROUND: This study retrospectively analyzes the use of chemotherapy in patients who died of advanced cancer either after having been in care at the Medical Oncology Unit (MOU) of the University Hospital of Bologna, Italy, or after having been assisted in their terminal disease phase by the Bologna Oncologi…

Septic cardiomyopathy (SCM) is a complication that is sepsis-associated cardiovascular failure. In the last few decades, there is progress in diagnosis and treatment despite the lack of consistent diagnostic criteria. According to current studies, several hypotheses about pathogenic mechanisms have been revealed to elu…

The treatment paradigm in metastatic renal cell carcinoma (mRCC) has evolved over the last 5 years. There are now seven approved targeted therapies against the vascular endothelial growth factor (VEGF) and mammalian target of rapamycin (mTOR) pathways. The use of targeted therapy, sequences, combinations, and investiga…