42,240 papers found

BACKGROUND: Chronic neck pain is a common problem with a poorly understood pathophysiology. Often no underlying structural pathology can be found and radiological imaging findings are more related to age than to a patient's symptoms. Besides its common occurrence, chronic idiopathic neck pain is also very disabling wit…

BACKGROUND: Treatment of sleep disorders in visually impaired children is complicated by a complex pathophysiology, a high incidence of sleep disorders in this population, and a dearth of management options. The significant impact on the health of these children and distress to their caregivers warrant a systematic ass…

INTRODUCTION: Traumatic brain injury (TBI) is a major global cause of death and disability. Hyponatremia is a frequent complication in neurocritical patients with TBI and has been associated with adverse clinical outcomes. However, the association between hyponatremia and mortality in patients with TBI remains uncertai…

INTRODUCTION: A patent processus vaginalis (PPV) is frequently observed during laparoscopic orchiopexy in infants with cryptorchidism. Nevertheless, the decision to primarily close the PPV following laparoscopic orchiopexy remains a subject of debate. This protocol therefore outlines the scope and methodology for a sys…

BACKGROUND: We aimed to evaluate the efficacy and safety of early analgesic interventions, particularly NSAIDs versus opioids, in reducing pain and improving clinical outcomes among adults with AP. METHODS: A systematic literature search was conducted across PubMed, Embase, Cochrane Central Register of Controlled Tria…

OBJECTIVES: To systematically review the literature on women's sexual quality of life after transvaginal natural orifice endoscopic surgery (vNOTES) for gynecological and nongynecological procedures, and to assess women's perceptions of vNOTES, the recommended duration of postoperative sexual abstinence (medically advi…

BACKGROUND: Severe early childhood caries (s-ECC) remains a highly prevalent condition among children worldwide, posing a considerable burden in both developed and developing regions. This systematic review seeks to comprehensively identify, synthesize, and critically evaluate available evidence on salivary proteomic a…

BACKGROUND: Hypertrophic cardiomyopathy (HCM) is a primary genetic myocardial disorder associated with sudden cardiac death (SCD) due to ventricular arrhythmias, however risk stratification remains challenging. Electrocardiographic (ECG) markers may offer non-invasive tools for improved risk assessment, but their progn…

BACKGROUND: This systematic review aims to assess whether extending Alt-RAMEC (Alternating Rapid Maxillary Expansions and Constrictions) protocols from four to nine weeks yields superior skeletal, dental, and soft-tissue outcomes in growing noncleft Class III patients when compared to conventional rapid maxillary expan…

BACKGROUND: Several antiarrhythmic agents, including amiodarone (AMD) and nifekalant (NIF), are used in the management of life-threatening arrhythmias such as ventricular fibrillation (VF) and ventricular tachycardia (VT). Although a few studies have compared the antiarrhythmic effect of NIF and AMD, most have focused…

PURPOSE: Maxillary sinus floor elevation is a safe and effective surgical technique for achieving vertical bone height, performed through either a lateral or crestal approach. The latter includes both the osteotome technique and osseodensification. The aim of this systematic review was to compare the outcomes of the cl…

RATIONALE: Although there is broad agreement that caffeine provides an acute improvement in attention in the normal population, estimates of effect size vary and the relationship between dose and effect is unclear. OBJECTIVE: To examine the acute effect of caffeine on attention in a systematic review and meta-analysis…

Gastrocolic fistula (GCF) is a rare but serious complication following metabolic bariatric surgery (MBS), primarily caused by leaks from the staple line or anastomotic sites. This systematic review aims to comprehensively analyze the diagnosis and management strategies for GCF following MBS. The Cochrane Central Regist…

Parkinson's Disease (PD) is a progressive neurodegenerative disorder characterized by motor impairments, including balance deficits, gait disturbances, and postural instability. Given the limitations of pharmacological treatments, alternative rehabilitative strategies such as Argentine Tango (AT) have been explored for…

BACKGROUND: In recent years, the association between systemic immune-inflammation index (SII) and the prognosis of patients with colorectal cancer (CRC) has remained a topic of considerable debate. To address this, the present study was carried out to investigate the prognostic significance of SII in CRC. METHODS: Dat…

Non-steroidal anti-inflammatory drugs (NSAIDs) are popularly used in the management of acute postoperative pain. Intravenous (IV) ketorolac has been used for several years for this purpose. Recently, IV ibuprofen has been introduced for the management of postoperative pain. This review aims to compare the efficacy…

BACKGROUND: Chronic obstructive pulmonary disease (COPD) is a progressive inflammatory disease that has a typical illness trajectory. Awareness of unique disease courses as well as providing end-of-life care (EOLC) for COPD patients is important as most patients experience varied degrees of suffering toward the end-of-…

Technological advancements have rapidly transformed medical education and surgical training, with virtual reality (VR) emerging as a valuable tool. VR offers immersive and interactive environments, enhancing the development of surgical skills without the risks that come with conventional training methods. In this revie…

Pain is a prevalent complaint in emergency departments (EDs) worldwide. Traditional pharmacological methods for pain relief, such as opioids and non-steroidal anti-inflammatory drugs (NSAIDs), have notable side effects and risks. Transcutaneous electrical nerve stimulation (TENS) is a non-pharmacological alternative th…

PURPOSE: To evaluate the effect of oncology services rendered by clinical pharmacists on reducing chemotherapy-induced nausea and vomiting (CINV) and improving overall treatment experiences. METHODS: A systematic review and meta-analysis were conducted using studies retrieved from PubMed, Embase, Cochrane Central Regi…