11,608,813 papers found

BACKGROUND: The incidence of asthma and asthmatic bronchitis (hereafter asthma) in Danish preschool children is estimated to be 10%-20%. Few well-controlled studies have been published on acupuncture and asthma, and no researchers have focused on asthma in preschool children. OBJECTIVE: The study's primary objective w…

BACKGROUND: Comprehensive data are unavailable for cardiac abnormalities in patients with neurofibromatosis type 1 (NF1). The goal of this study was to evaluate the prevalence of cardiovascular abnormalities with echocardiography with color Doppler scan (ECHO) in a large, consecutive series of patients with NF1. METHO…

BACKGROUND: The promotion of healthy eating is more likely to be effective if based on the understanding of how the elderly perceive their own diets and healthy eating. OBJECTIVES: The objectives of this study were to identify in the elderly European population, the attitudes to food, nutrition and health, in order to…

BACKGROUND: Despite extensive coverage in recent literature, controversy continues with regard to the relative sensitivities of computed tomography (CT) and physical examination (PE). OBJECTIVE: To identify a statistically significant consensus. DATA SOURCES: Initially, data were reviewed on 47 consecutive patients w…

Although IgA isotype testing does not enhance diagnostic accuracy of antiphospholipid syndrome (APS), recent studies suggest that IgA aCL/aβ2GPI are associated with systemic lupus erythematosus (SLE) and thrombosis, contributing to thromboinflammatory responses and potentially serving as prognostic markers. This…

BACKGROUND: Studying illicit drug circulation and its effects on population health is complicated due to the criminalization of trade and consumption. Illicit drug markets have evolved with IT, moving digital to the "darknet." Previous research has analyzed darknet market listings and customer reviews. Research tools i…

CONTEXT: Internationally, studies suggest that inadequate comprehension of the concept of palliative care and misconceptions about it hinder the effective use of palliative care, especially in developing nations. OBJECTIVE: To assess the awareness of the adult population in Jordan regarding palliative care. METHODS:…

The aim of our study was to describe and to investigate the factors associated with glycopeptide-resistant enterococci (GRE) acquisition during a single-strain outbreak which occurred in several wards of hospital from September 2013 to January 2014. We designed a case-control study. Analyses were performed using Bayesi…

BACKGROUND: Cohort studies are pivotal in understanding the natural history, and to thereby determine the incidence of a disease. The conduct of large-scale community-based cohort studies is challenging with reference to money, manpower and time. Further, attrition inherent to cohort studies can affect the power, and t…

OBJECTIVE: To assess the technical performance (proportion of technical failure and unreliable measurements) of shear wave elastography (SWE) for assessing liver stiffness in pediatric and adolescent patients. METHODS: We searched Ovid-MEDLINE and EMBASE databases for eligible studies and selected original articles in…

PURPOSE: Determinants of the natural history of recurrent herpes simplex virus (HSV) keratitis have not been consistently established. We assessed how previous HSV eye disease affects the risk of recurrent HSV keratitis and evaluated whether demographic and other variables play any predictive role. METHODS: Three hund…

INTRODUCTION: Stigma remains a major barrier to accessing healthcare for people with neurological disorders. The World Health Organization's Intersectoral Global Action Plan on epilepsy and other neurological disorders urges all member countries to have at least one functioning awareness campaign for neurological disor…

INTRODUCTION: Clinical trials are critical to the advancement of medical knowledge. However, the reliability of trial conclusions depends in part on consistency between pre-planned and reported study outcomes. Unfortunately, selective outcome reporting, in which outcomes reported in published manuscripts differ from pr…

Pioneering work in human neuroscience has relied on the ability to map brain function using task-based fMRI, but the empirical validity of these inferential methods is still being characterized. A recent landmark study by Eklund and colleagues showed that popular multiple comparison corrections based on cluster extent…

Despite their important role in security, little is known about the energy requirements of working dogs such as odor, explosive and human detection dogs. Previous researchers have evaluated the energy requirements of individual canine breeds as well as dogs in exercise roles such as sprint racing. This study is the fir…

Human exposure to micro- and nanoplastics (MNPs) is increasingly documented, yet their potential effects on reproductive and developmental health remain inadequately explored. Preliminary findings presented in scientific literature suggest that MNPs may translocate systemically and localize in reproductive tissues, pro…

OBJECTIVE: Urostomy profoundly alters the body image of bladder cancer patients, leading to a series of physiological, psychological, social, and functional changes. This review aims to synthesize qualitative research on urostomy patients' life experiences to provide healthcare professionals with a complete understandi…

BACKGROUND: Trocar site hernia (TsH) is an uncommon complication of bariatric surgery but potentially serious. People with obesity are more susceptible due to the difficulty in approximating fascial tissue. This study aims to investigate whether fascial closure (FC) or non-fascial closure (NFC) of trocar sites, in pati…

The X-ray crystal structure of human S-adenosylhomocysteine (AdoHcy) hydrolase was first determined as a tetrameric form bound with the novel mechanism-based inhibitor fluoroneplanocin A (4b). The crystallized enzyme complex showed the closed conformation and turned out to be the intermediate of mechanism-based inhibit…