381,725 papers found

ARTICLE TITLE AND BIBLIOGRAPHIC INFORMATION: The International Caries Detection and Assessment System-ICDAS: A Systematic Review. Ekstrand KR, Gimenez T, Ferreira FR, Mendes FM, Braga MM. Caries Res 2018; 52:406-419. SOURCE OF FUNDING: Government FAPESP, the Sao Paulo Research Foundation (FAPESP 2012/17888-1 and 2014/…

Recently a number of acupuncture clinical trial projects mainly conducted by conventional scientists have generated many negative results. A large meta-analysis of patient-level acupuncture data for the treatment of chronic pain conditions have demonstrated that the effects of verum acupuncture on pain improvement have…

The clinical introduction of rTMS for the treatment of depression is now progressing in Japan. On the basis of the successful results of a large-scale RCT, the US FDA approved an rTMS device in 2008, and four rTMS devices are now approved and used in several countries and the EC. The results of the meta-analysis of RCT…

Meta-analysis, a tool for contrasting and combining results from different research studies, has been around now for over 40 years. Journal editors are eager to publish the results from meta-analyses, as they propose to represent the integration of best research evidence with clinical expertise and patient values. Ther…

A focus on novel, confirmatory, and statistically significant results leads to substantial bias in the scientific literature. One type of bias, known as "p-hacking," occurs when researchers collect or select data or statistical analyses until nonsignificant results become significant. Here, we use text-mining to demons…

Widespread use of microarray technology that led to highly complex datasets often is addressing similar or related biological questions. In translational medicine research is often based on measurements that have been obtained at different points in time. However, the researcher looks at them as a progression over time…

A systematic review aims to synthesize all available individual studies on a certain topic and uses explicit and reproducible methods for searching the literature, while a meta-analysis is a mathematical synthesis of the results of these individual studies. Because of the explosion of information in the scientific lite…

It is well known that when a Bayesian meta-analysis includes a small number of studies, inference can be sensitive to the choice of prior for the between-study variance. Choosing a vague prior does not solve the problem, as inferences can be substantially different depending on the degree of vagueness. Moreover, becaus…

The effects of drugs on new cancer and cancer-related death are a major concern. Recently, a meta-analysis raised the possibility that ARBs might have an adverse impact in this respect. This point of view was highly debated until the publication of two other meta-analyses which did not demonstrate any increased risk of…

Meta-analyses have followed some of the most important advances in the treatment of early-stage Hodgkin lymphoma (HL). In this review, details on all meta-analyses of patients with early-stage HL are discussed. In 1990, the first meta-analysis addressing patients with early-stage HL compared radiotherapy alone to combi…

UNLABELLED: Founded upon the database of 570 public signatures, ICPS is a web-based application to obtain biomarker profiles among 11 common cancers by integrating genomic alterations with transcription signatures on the basis of a previously developed integrative pipeline. ICPS supports both public data and user's in-…

Animal-pollinated angiosperms either depend on cross-pollination or may also reproduce after self-pollination - the former are thus obligately, the latter facultatively dependent on the service of animal-pollinators. Analogously, flower visitors either solely feed on floral resources or complement their diet with these…

Review papers commonly summarize the current knowledge on a selected topic. These types of papers are considered narrative reviews. Narrative reviews rarely detail the methods used to select the literature included, nor do the authors typically report the purpose of the review. Narrative reviews may be biased due to in…

We describe a new multivariate gamma distribution and discuss its implication in a Poisson-correlated gamma-frailty model. This model is introduced to account for between-subjects correlation occurring in longitudinal count data. For likelihood-based inference involving distributions in which high-dimensional dependenc…

The quantitative analysis of the various clinical researches is carried out by means of special statistical data manipulation. It allows to receive results which cannot be taken from separate researches. In the article methodological bases of the meta-analysis and an opportunity of its application and interpretation in…

A comment on the conduct of a meta-analysis analyzing the effects of statins on cardiovascular and cerebrovascular outcomes is presented in this editorial. Competing risk and risk-stratified analysis models that may be more appropriate for the analysis of clinical trials in general and statin trials in particular are i…

PURPOSE: This paper describes the hierarchy of analytical studies, from the observational studies to the experimental ones. STATE OF THE ART AND MAIN POINTS: Case-control studies, the most frequently performed among analytical studies, may generate or confirm hypotheses. They are of particular use for rare diseases. C…

J. B. Miner and N. S. Raju (2004) contended that there are additional studies that compare the risk propensity of entrepreneurs and managers, which, when added to the data from W. H. Stewart and P. L. Roth (2001) and meta-analyzed, produce relationships between risk propensity and entrepreneurial status that are substa…