42,236 papers found

BACKGROUND: Treatment of sleep disorders in visually impaired children is complicated by a complex pathophysiology, a high incidence of sleep disorders in this population, and a dearth of management options. The significant impact on the health of these children and distress to their caregivers warrant a systematic ass…

The text discusses the case of a patient who experienced pneumopericardium because of a traumatic incident. It discusses pneumopericardium's causes, symptoms, and complications, including tamponade symptoms and imaging modalities, to confirm the diagnosis and assess complications. Present various treatment options emph…

BACKGROUND AND AIMS: Diabetes is a global concern. This article took a closer look at diabetes and precision medicine. METHODS: A literature search of studies related to the use of precision medicine in diabetes care was conducted in various databases (PubMed, Google Scholar, and Scopus). RESULTS: Precision medicine…

OBJECTIVE: The aim of this systematic review was to provide an overview of cross-sectional studies that examined health literacy among university students and to identify possible determinants related to health literacy. METHOD: The current review was conducted according to the Preferred Reporting Items for Systematic…

Within the last few years, there have been an increased number of clinical studies involving urinary microbiota. Low-biomass microbiome sequencing (e.g., urine, lung, placenta, blood) is easily biased by contamination or cross-contamination. So far, a few critical steps, from sampling urine to processing and analyzing,…

Sofpironium bromide is a recently approved topical anticholinergic agent for primary axillary hyperhidrosis, developed using a retrometabolic approach to limit systemic side effects. However, randomized evidence about its effects has not yet been quantitatively synthesized. This meta-analysis aimed to assess the effica…

BACKGROUND: Lipoprotein(a)-targeted therapies are emerging approaches for lowering lipoprotein(a) [lp(a)]. OBJECTIVE: We conducted a systematic review and network meta-analysis to evaluate the efficacy and safety of lipoprotein(a)-targeted therapies in patients. METHODS: We searched PubMed, Embase, Web of Science, an…

Early detection of arthritis in autoimmune rheumatic diseases (ARDs) is critical to prevent irreversible damage. Joint ultrasound (US) offers high sensitivity and availability in a routine clinical practice. However, US is limited by examiner dependency and resource requirements. Infrared thermography (IRT) is a non-in…

OBJECTIVE: This review will investigate the effectiveness of nasoalveolar molding (NAM) in patients with non-syndromic bilateral cleft lip and palate (BCLP), compared to no intervention in patients with non-syndromic BCLP, patients with non-syndromic unilateral cleft lip and palate (UCLP), and non-cleft control subject…

Glutamatergic neurons represent 40% of neurons in the human central nervous system. Glutamate accounts for approximately 90% of all excitatory neurotransmitters. Previous research reports the presence of glucagon-like peptide-1 (GLP-1) receptors on neurons that produce glutamate. Herein, we aim to evaluate whether GLP-…

BACKGROUND: Central nervous system tuberculosis (CNS-TB), most frequently manifesting as tuberculous meningitis, is associated with high mortality and significant long-term neurological morbidity. Increasing evidence suggests that disease severity and neurological damage are driven largely by dysregulated host neuroinf…

OBJECTIVES: Aortic valve replacement with Trifecta valve provides a greater early haemodynamic performance with its externally mounted structure. However, failure rates in short-term post-implantation started to be reported, which brought great attention towards understanding the mechanisms of failure and optimal appro…

BACKGROUND AND AIMS: This study aims to evaluate the diagnostic accuracy of tools commonly employed in clinical practice for the assessment of malnutrition in patients with inflammatory bowel disease (IBD), including Global Leadership Initiative on Malnutrition (GLIM) criteria, Subjective Global Assessment (SGA), Europ…

BACKGROUND: The placebo effect is increasingly recognized in rehabilitation, yet its mechanisms remain poorly understood. Brain oscillations offer a non-invasive, time-sensitive and dynamic measure of neural activity, making them ideal for capturing the dynamic changes linked to placebo responses. This study explores o…

Cardiovascular disease is a principal cause of morbidity and mortality worldwide, disproportionately affecting individuals with type 2 diabetes mellitus (T2DM) and heart failure. Empagliflozin, a sodium-glucose cotransporter 2 inhibitor, has shown promising cardioprotective effects beyond its glucose-lowering prop…

BACKGROUND: Peroral endoscopic myotomy (POEM) is a standard achalasia treatment, matching surgery in efficacy. However, myotomy length varies. Shorter myotomies are gaining attention for potential benefits. This study compares short versus long myotomies to identify the optimal approach. METHODS: We conducted a system…

INTRODUCTION: Sexual dysfunctions are a challenging side effect associated with antipsychotic treatment. This protocol outlines a systematic review and meta-analysis to assess the prevalence of overall sexual dysfunction, as well as the specific phases of sexual function affected by antipsychotic medications. Additiona…

: The comparative efficacy and optimal combination strategies of exercise intervention, nutritional supplementation, and their integration for older women with sarcopenia remain inadequately supported by high-quality evidence.: We systematically searched PubMed, Embase, Web of Science, and the Cochrane Central Register…

OBJECTIVE: The aim of this systematic review will be to evaluate the effectiveness of palliative care for treating adults with end-stage liver disease (ESLD), focusing on outcomes such as quality of life, quality of care, symptom burden, and patient satisfaction. INTRODUCTION: ESLD is a critical health issue, characte…

BACKGROUND: Asthma is a common chronic inflammatory disease affecting children worldwide. While probiotics have been proposed as a potential therapy, their efficacy in pediatric asthma management remains controversial. METHODS: A systematic search of PubMed, Web of Science, Embase, Cochrane Central Register of Control…