386,737 papers found

BACKGROUND: Psoriasis has been linked to cardiovascular disease (CVD), including coronary artery disease (CAD), myocardial infarction (MI), and heart failure (HF). However, available studies regarding this relationship have shown inconsistent results. Therefore, in this report, we performed a comprehensive review of th…

PURPOSE: Quinone oxidoreductase (NQO1) C609T polymorphisms have been implicated in acute lymphoblastic leukemia (ALL) risk, but previously published studies were inconsistent and recent meta-analyses were not adequate. The aim of this study was to determine more precise estimations for the relationship between the NQO1…

From 1983 to 1987, the Department of Veterans Affairs (DVA) Cooperative Studies Program (CSP) conducted a multicenter clinical trial (CSP #207) to determine whether four different antiplatelet regimens compared to placebo could prevent the occlusion of grafts following coronary artery bypass surgery. The study showed t…

BACKGROUND: Recent studies assert that sugar-containing drinks may play a key role in the etiology of obesity. However, scientific reviews show contradictory results. Whether there is just association or clear causation still is a matter of debate. It is also subject to discussion whether the quality/adequacy of the di…

Violent video games are theorized to be a significant cause of aggressive thoughts, feelings, and behaviors. Important evidence for this claim comes from a large meta-analysis by Anderson and colleagues (2010), who found effects of violent games in experimental, cross-sectional, and longitudinal research. In that meta-…

OBJECTIVE: To estimate the comparative effectiveness of medical interventions in adults versus children. STUDY DESIGN: We identified from the Cochrane Database of Systematic Reviews (Issue 1, 2007) meta-analyses with data on at least 1 adult and 1 pediatric randomized trial with binary primary efficacy outcome. For ea…

OBJECTIVE: To evaluate the treatment of bacterial vaginosis with metronidazole to determine if there is a therapeutic regimen that is superior to all others with regard to cure and recurrence rates. DATA SOURCES: Computer-assisted literature search, Medical Subject Index review, and references cited in articles identi…

Over the last decade, a number of studies have attempted to relate brain morphology to treatment response to neuroleptics. This approach has scientific potential to define subtypes of schizophrenia as well as potential clinical utility. In the present report, a review of 33 studies, including a meta-analysis, is provid…

Several postinfarction trials have evaluated the effect of secondary prophylaxis with different beta-blockers. Although so called meta-analysis of the results from all the trials have shown a beneficial effect of postinfarction beta-blockade, many of the individual studies have shown inconclusive results, mainly due to…

The discovery that beta blockers possess clinically useful hypotensive, antianginal and antiarrhythmic properties has attracted the interest of clinicians, researchers and the pharmaceutical community alike. In addition, minor differences in a variety of ancillary properties have led to speculation that specific classe…

BACKGROUND: Tranexamic acid (TXA) is widely used to reduce blood loss in spine surgery. Different administration routes, including intravenous (IV), topical, and oral, have been studied, but a comprehensive comparison of their efficacy and safety remains lacking. This network meta-analysis aims to compare the effective…

IMPORTANCE: Retractions are rising in the scientific literature, increasing the risk of reusing unreliable results. OBJECTIVES: To identify reports of systematic reviews that included retracted studies in their meta-analyses, and to assess the impact of these retracted studies on the results. DESIGN, SETTING, AND PAR…

BACKGROUND: Statins have been shown to reduce the risk of all-cause mortality among individuals with clinical history of coronary heart disease. However, it remains uncertain whether statins have similar mortality benefit in a high-risk primary prevention setting. Notably, all systematic reviews to date included trials…

BACKGROUND AND HYPOTHESIS: Identifying generalizable brain imaging markers from large multi-center datasets remains challenging due to varying statistical aggregation approaches and p-hacking with increasing big data. We hypothesized that effect size (ES) inference surpasses P-value-based inference in reliably identify…

Despite the common lay assumption that males and females are profoundly different, Hyde (2005) used data from 46 meta-analyses to demonstrate that males and females are highly similar. Nonetheless, the gender similarities hypothesis has remained controversial. Since Hyde's provocative report, there has been an explosio…

This article reviews psychosocial correlates of adolescent substance use by focusing on the recent empirical literature. Using a tabular format, an attempt is made to provide a facile tool for referencing the literature. Examination of the literature reveals considerable diversity among explanations regarding the varia…

Incidental carcinoma of the prostate is a protean disease with a natural course which may be indolent or aggressive, with prognosis correlated with histologic grade and extent of disease. Treatment of this pathologic entity has varied over time and has been governed by institutional policy rather than randomized compar…

The histologic and cytologic distinction of malignant mesothelioma from carcinomas metastatic to the pleura or peritoneum is often problematic. For this reason immunologic methods are being increasingly used as diagnostic adjuncts. This review summarizes 40 studies on the expression of carcinoembryonic antigen in mesot…

Coronary heart disease mortality has declined in the United States since 1968. Because diet has been implicated, a search was conducted of published individual assessments of food intake since 1920. One hundred seventy-one studies, ranging from 8 to 20,000 subjects and covering all ages, all ethnic groups, and both sex…

Flow cytometric determination of DNA ploidy, the DNA index, and the percentage of cells in the S-phase fraction of the cell cycle have recently emerged as prognostic factors in several human cancers. In most human carcinomas DNA aneuploidy appears to be associated with unfavorable prognosis as compared with diploid or…