98,302 papers found

Peptides have unique properties that make them useful drug candidates for diverse indications, including allergy, infectious disease and cancer. Some peptides are intrinsically bioactive, while others can be used to induce precise immune responses by defining a minimal immunogenic region. The limitations of peptides, s…

The objective of this study was to analyze in detail the time trend in prostate cancer mortality in the population of Tyrol, Austria. In Tyrol, prostate-specific antigen tests were introduced in 1988-1989 and, since 1993, have been offered to all men aged 45-74 years free of charge. More than three quarters of all men…

OBJECTIVE: The aim of this study was to evaluate, in runners participating in the 2019 Rome Marathon, the interaction between resilience and coping and how they are influenced by sex, age, body weight, height, number of weekly training sessions, and the time of the last marathon. DESIGN: Cross-sectional study. SETTIN…

OBJECTIVE: To identify factors associated with the neurological outcome of HSVE in children. MATERIALS AND METHODS: In this retrospective multicentric observational study, clinical, paraclinical data at onset and neurological outcomes at last follow-up of children (&#x2265;28 days and <18 years old) with HSVE, were st…

BACKGROUND: Multiple endocrine neoplasia type 2 syndrome (MEN2) is a hereditary disease resulting from mutations of the rearranged during transfection (RET) protooncogene subclassified into MEN2A [medullary thyroid carcinoma (MTC), pheochromocytoma, and primary hyperparathyroidism] and MEN2B (MTC, pheochromocytoma, Mar…

BACKGROUND: Hereditary angioedema (HAE) with C1-inhibitor deficiency is associated with painful, potentially fatal attacks affecting subcutaneous or submucosal tissues. OBJECTIVE: To evaluate HAE burden from the patients' perspective. METHODS: This was a noninterventional survey of patients with HAE in the United Sta…

IMPORTANCE: Rhinoplasty is a common operation in which shape and function are intimately related, whether the procedure is cosmetic, functional, or combined in nature. There is currently no properly developed and validated patient-reported outcome measure (PROM) to evaluate both functional and cosmetic components of rh…

Outcome and Prognostic Factors of Community-Acquired Pneumonia (CAP) (I-V): A pre-existing illness or alcoholism was present in 60% of 53 patients with CAP requiring treatment in an intensive care unit (ICU). An etiological diagnosis was established in only half of the patients, with S. pneumoniae as the predominating…

Background Drug abuse has been on the increase over the last few years, contributing to the healthcare cost. An understanding of the overall impact of drug abuse hospitalizations is essential in combatting the drug abuse epidemic. Objective To evaluate inpatient outcomes of total charges&#xa0;and length of stay for pat…

UNLABELLED: Cable-wakeboarding has become more and more popular in the last years in Germany and worldwide as well. The mechanism, frequency and severity of injuries is still unclear and not described in the literature yet. Thus to compare the injuries of cable-wakeboarding with similar sports we decided to perform thi…

Neural damage leads to a transient or persistent alteration, depending on the severity or type of injury sustained. During the last decade, many investigators reported on paresthesia related to dental implants. In this case report, the patient had presented repeatedly with swelling and suppuration, showing typical sign…

In the German National Health Interview and Examination Survey 1998 several anthropometric data were obtained from 7124 men and women, aged 18-79 years. These data were analysed and compared with 1990/92 survey data. On average, people form the Western part of Germany are somewhat taller than those from the Eastern par…

A study on the frequency of Chlamydia trachomatis (Ct) urogenital infection comprised 2393 patients (1,197 women and 1,196 men), aged 18-69 years. Urethral and cervical specimens were tested using immunofluorescent (DFA) for symptomatic and immunoenzymatic techniques (EIA, IMx, Vidas-ELFA) for asymptomatic patients. Ba…

PURPOSE: We present our management algorithm for patients with anterior urethral valves seen in the last 2 decades with and without the benefit of prenatal sonography. MATERIALS AND METHODS: A case series design was used to study 17 cases of anterior urethral valves. Five patients presented with prenatal hydronephrosi…

To evaluate the relationship between use of oral contraceptives and risk of invasive cervical cancer, a case-control study involving 479 patients and 789 population controls was undertaken in 5 geographic regions of the US. Initially, the relationship was obscured by confounding variables, particularly the interval sin…

An increasing number of wearable devices performing eye gaze tracking have been released in recent years. Such devices can lead to unprecedented opportunities in many applications. However, staying updated regarding the continuous advances and gathering the technical features that allow to choose the best device for a…

The assessment and management of tricuspid valve (TV) disease evolved significantly in the last decade. Tricuspid regurgitation (TR) is a frequent heart valve disease and it is most often secondary, due to annular dilatation and leaflet tethering from right ventricular remodeling. The indications for TV surgery are sev…

The role of viral infections in ocular pathology varies greatly, involving all the components of the eye. Some viruses like herpes simplex, herpes zoster, adenovirus, enterovirus 70, influenza virus, human immunodeficiency virus, and cytomegalovirus are well-known for their role in ocular pathology. In recent years, em…

During the last 12 years, antibody combinatorial libraries have provided a new approach for the construction and production of reagents and drugs based on the human monoclonal antibodies. Studies employing antibodies or antibody mimics have become an important part of the explosive growth of proteomics. This places tre…

BACKGROUND: ACE inhibitors and beta blockers have reduced morbidity and mortality from chronic heart failure significantly during the last years. Apart from medical therapy several surgical strategies for the treatment of heart failure are available. PREREQUISITES OF SURGICAL TREATMENT: Surgical treatment should be di…