1,557,958 papers found

The nurse's role as a clinical trial data manager is a vital component of the success of the trial. Physicians rely on the nurse's expertise as a skilled observer to gather clinical data; act as a liaison to the many agencies involved in the study; instruct patients, families, and colleagues; and assess the information…

Patients with severe Guillain-Barre syndrome were entered into 2 groups: group I was treated with hormones alone, group II with hormones plus plasmapheresis. The results were not significantly different. In view of recognized effectiveness of plasmapheresis for treatment of the syndrome, corticosteroid addition is inap…

Epoetin alfa is a glycoprotein with the same DNA structure and biological effects as endogenous erythropoietin. Clinical studies have demonstrated that Epoetin alfa effectively maintains RBC levels, decreases the need for transfusions, and improves the overall quality of life in anemic, ESRD, dialysis patients. The sid…

Nine patients with classic rheumatoid arthritis underwent first placebo-hemosorption and then hemosorption. According to the arthrogram there was no significant difference between the action of these two procedures during the first three days. Both procedures evoked activation of the complement system and changed the b…

To investigate the relationship between naturally occurring and drug-induced panic attacks, we compared the phenomenology of panic attacks in 12 panic disorder patients who panicked during both placebo and lactate infusion and in 9 panic disorder patients who panicked during both placebo and isoproterenol infusions. Pa…

Twenty subjects entered a double-blind placebo-controlled trial of SAM in depression. Prolactin concentrations were measured before and after 14 days' treatment. There was a highly significant fall in prolactin concentrations in the SAM-treated group.

Psychiatric inpatients with tardive dyskinesia (TD) were treated with either lithium alone (n = 9) or with a combination of lithium and lecithin (n = 9) for 5 weeks in a double-blind, placebo-controlled experiment. A statistically significant but clinically unimportant improvement of TD occurred during both treatments.…

The efficacy of an orally administered calcium antagonist, nifedipine, in suppressing premature uterine activity, was compared with intravenous ritodrine and no treatment. Nifedipine was found to be significantly more effective than ritodrine or withholding therapy, and was almost devoid of side-effects.

A double-blind crossover study that compared clonidine and a placebo, which were administered to 19 postmenopausal women who were suffering from hot flushes, failed to demonstrate any statistical reduction in the number of hot flushes. Therefore, clonidine is not recommended as a treatment drug for this symptom.

The study confirmed the usefulness of both pirprofen and piroxicam in a short-term treatment of decompensated osteoarthritis of weight-bearing joints associated with night pain. Both drugs were fairly tolerated. The tolerance of pirprofen was somewhat better then that of piroxicam.

Ceruletide, a cholecystokinin analogue, has been reported to interact with dopamine in the CNS and to benefit schizophrenic individuals. The authors, using a double-blind design, a higher total dose, and a larger sample size than previous studies, found no evidence of benefit.

The efficacy of salbutamol was assessed in a double blind placebo controlled crossover study in nine hospitalized children with whooping cough in the convulsive stage verified by culture or serology. The children were 1.5 to 27 months old (median, 4 months). The dosage of salbutamol was the one normally used and supple…

The effect of metoclopramide and placebo was tested in 50 patients with an endoscopically and bioptically ascertained ventricular ulcer. In this case was started from the consideration that the motility of the stomach might play a role in the pathophysiology of the origination of ulcer. Indeed, metoclopramide is superi…