1,557,958 papers found

The effect of metoclopramide and placebo was tested in 50 patients with an endoscopically and bioptically ascertained ventricular ulcer. In this case was started from the consideration that the motility of the stomach might play a role in the pathophysiology of the origination of ulcer. Indeed, metoclopramide is superi…

Data from a 3-yr clinical trial were used to assess reliability of two dentists who, without standardizing techniques, independently examined 286 continuous participants. Only 13.1 of 128 tooth surfaces (third molars excluded) showed a change in caries status during the trial by one or both examiners' findings. Althoug…

The early (30-day) dislodgment rate of standard-use flange-tipped and of tined endocardial electrodes was compared in a randomized prospective clinical trial. Four of 16 (25%) of the flange-tipped leads and none of the 18 tined leads dislodged within 30 days of implantation (p = 0.01). We believe that the tined electro…

A controlled study comparing salbutamol (6 mg/day) to clomipramine (150 mg/day), both given by intravenous infusion, was performed on depressed inpatients (10 per group). The symptomatology was evaluated by two blind observers at days 0, 5, and 15 using the Hamilton Rating Scale. Both treatments were effective on the o…

The authors report their initial experience with Amipaque (metrizamide) in hysterosalpingography. Amipaque was compared to Isopaque Cerebral in 37 patients, using a double-blind design. Excellent radiographs were obtained with both agents. No statistically significant difference in discomfort and pain was found up to 2…

A double-blind cross-over study of 35 out-patients with rheumatoid arthritis showed that Naproxen and Indomethacin suppositories were both effective forms of treatment in rheumatoid arthritis, both being significantly superior to placebo in terms of relief of morning stiffness.

In a prospective, controlled and double-blind investigation the influence of heparin--added to the dialysis solution--on the lapse of peritoneal dialysis is studied. The material comprises 9 patients, all of whom had 2 peritoneal dialysis, one with and one without heparin added to the dialysis solution. A significantly…

After 7 years of use of a Na2FPO3 paste, the reduction of DMF surfaces was reduced by 36-38%, relating to the control group. The caries inhibiting effect is statistically ensured. Separate consideration of the first molar shows a caries reduction of 40-42%.

In a double-blind study the therapeutic effect and tolerance of pizotifen was compared with placebo in 20 outpatients of both sexes suffering from light to moderate depression. Pizotifen seems to possess certain antidepressive effects in dosages of 4-10 mg daily. These properties, and the well-documented effect of pizo…

Sotalol, a beta-adrenergic blocking agent devoid of intrinsic sympathicomimetic activity and local anaesthetic properties, was assessed in a double-blind cross-over study for the symptomatic treatment of 10 patients with thyrotoxicosis. The heart rate and clinical thyrotoxicosis index were significantly lower than with…

A new anti-spasticity agent, brolitene, has been assessed in patients with spasticity of spinal or cerebral origin. Twenty-seven patients were entered in a double-blind cross-over trial lasting 6 weeks, using a fixed dose of six tablets (1200 mg brolitene) per day. Clinical assessment failed to show any therapeutic eff…

A double-blind comparison of lorazepam and placebo, lorazepam and pentobarbital, and a comparison of lorazepam IV drip versus lorazepam IV bolus as a premedicant showed this new agent to offer promise as a sedative premedicant. However, the potency of the drug demands caution, and its use for outpatient premedication i…