98,296 papers found

BACKGROUND: Although rare, cutaneous small-vessel vasculitis (CSVV) secondary to solid organ malignancy has been documented. OBJECTIVE: We sought to better understand the frequency, clinical course, therapeutic response, and outcome of CSVV associated with solid organ malignancy. METHODS: We conducted a retrospective…

BACKGROUND: The LNG-IUS has increasingly been used for contraception, treatment of menorrhagia and endometrial protection during hormone replacement therapy since mid-1990s. Thus, many women use the LNG-IUS consecutively. However, published data on the bleeding pattern regarding consecutive use of the LNG-IUS is scarce…

Purpose of this study was to determine the rate of contamination, defined as lung cancer screening in the control arm, of the Dutch-Belgian randomized lung cancer screening trial (NELSON) as contamination adversely affects the power of a trial. The NELSON cohort includes 15,822 high-risk current and former smokers, age…

BACKGROUND: Oral fluid (OF) is an exciting alternative matrix for monitoring drugs of abuse in workplace, clinical toxicology, criminal justice, and driving under the influence of drugs (DUID) programs. During the last 5 years, scientific and technological advances in OF collection, point-of-collection testing devices,…

BACKGROUND: Previous studies have shown an association between diabetes mellitus (DM) and urinary incontinence (UI) in women, especially severe UI. The purpose of this study was to investigate whether diabetes related variables could explain this association. METHODS: The study is part of the EPINCONT study, which is…

PURPOSE: Natural orifice transluminal endoscopic surgery (NOTES) is a novel technique that aims at reducing or abolishing skin incisions and potentially also postoperative pain. The purpose of this study was to analyse operative and long-term results of a series of hybrid transvaginal cholecystectomy. MATERIALS AND ME…

Recent studies have shown that the detrimental effects of sports concussions on cognitive and motor function may persist up to a few years post-injury. The present study sought to investigate the effects of having sustained a sports concussion more than 30 years prior to testing on cognitive and motor functions. Ninete…

BACKGROUND: Although the ideal treatment of thumb basal joint osteoarthritis is debated, most surgeons advocate trapeziectomy with ligament reconstruction tendon interposition arthroplasty. However, harvesting and weaving autologous tendon creates scarring, alters wrist kinetics, may prolong recovery, and is time consu…

OBJECTIVE: We sought to examine the frequency and the specific problems encountered in accessing Internet references in two leading medical journals during the last 3 years. METHODS: Two investigators independently reviewed all publications in the issues of the New England Journal of Medicine and The Lancet during Oct…

A young patient with a severe and isolated memory disorder, meeting the criteria for MCI, was followed for a period of 8 years. His overall functional level remained stable with a CDR-score at 0.5 until the last year when it dropped to 1.0. Neuropsychological testing showed severe memory deficits but otherwise normal c…

BACKGROUND: Although patients with pectus carinatum (PC) often experience moderate to severe symptoms, there are sparse published data about the indications for correction, the newer techniques of surgical repair, and the results. This study reviews clinical experience with new, less extensive, open operative technique…

INTRODUCTION: Secondary adaptive bone changes and joint distorsions in clubfoot may present a barrier to adequate correction of the deformity. The purpose of our study is to show how the lateral excision of the calcaneus distal part as described by Lichtblau, in combination with an appropriate medial release allows bet…

The 5-year survival rate for malignant melanoma has increased 40% over the last 50 years. During this same time period, the treatment for the disease has not changed significantly, and consists of wide excision of the primary tumour and perhaps regional node dissection. The purpose of this study was to investigate the…

In 1984 an investigation was done among a random sample of 400 old-age pensioners, 67 yrs, and older, who were either inmates of old people's residential or nursing homes or long-term patients in geriatric departments at the hospitals in Reykjavík. A dentist asked all participants standardised questions, among whi…

BACKGROUND: The goal of this study was to analyze long-term consequences of ifosfamide-induced nephrotoxicity on growth and renal function in children treated for cancer. PROCEDURE: In a retrospective study, departments for pediatric oncology and nephrology in Germany, Austria, and Switzerland were asked to report pat…

Surgical treatment of cardiac achalasia in children is still the main line of treatment with a success rate of 70-80%. Balloon dilatation is less widely used due to inappropriate size of balloons. The authors report on their experience in 11 children with cardiac achalasia over the last 7 years using balloon dilatation…

Intraplate hotspots deform the Earth's lithosphere and shape the morphology of reef-bound islands. This paper constrains the depositional history of the coastal plain of O'ahu, Hawaii over the past 2 million years using: (1) the strontium isotope stratigraphy of shallow water carbonates (e.g., corals, mollusks) sampled…

We report a rare case of episiotomy site scar endometriosis manifested as painful perineal swelling near the anus for 2 years affecting daily routine activity, especially during menses. A 33-year-old female, para 2 with both vaginal deliveries with last child birth 8 years back. A 2.5 × 3 cm firm, te…

BACKGROUND: Fisheries and aquaculture are statistically acknowledged to be among the most dangerous occupations. Yet, industrial safety and health precautions against occupational accidents within the sector are not sufficiently implemented in many parts of the world. The present study aims to provide a quantified over…

Seafood is a major cause of food allergy and anaphylaxis worldwide. Shellfish is included among the "big eight" food groups, which are responsible for more than 90% of all cases of food allergy. Approximately 2.5% of the world's population has experienced an adverse reaction to seafood. Seafood allergy is one of the mo…