1,557,903 papers found

A randomized, prospective comparison of radical peritoneal debridement and standard surgical management of peritonitis disclosed no differences in terms of hospital mortality for the frequency of reoperation for abscess. Adjunctive measures such as antibiotic therapy and peritoneal irrigation were identical between the…

Fourteen patients with a variety of ataxic disorders were given choline chloride, double blind for six weeks, in an attempt to improve gait and manual dexterity. One patient withdrew before receiving the active drug, twelve patients showed no functional improvement, but one achieved greater mobility; his response, whic…

The phenomenon of regression to the mean is widespread. It may affect any quantitative biological data in which there is "within subject" variability. It is demonstrated, as an example in practice, by a shift from high to lower values with time in a selected subset of patients with an abnormally high blood cholesterol.…

Nine patients with hypertension were given xipamide 40 mg orally as monotherapy on alternate days. An additional seventeen patients had xipamide added to an existing treatment regime of clonidine 450 micrograms per day. Xipamide alone produced a significant fall in blood pressure comparable to that obtained with clonid…

A eutectic mixture of lidocaine and prilocaine in a water emulsion cream base produces effective superficial dermal analgesia when applied under occlusive dressing for 60 minutes. On the genitals, lips and oral mucosa, the application time can be reduced. The cream was found to be an effective alternative to convention…

Intra-articular injections of erbium--169 citrate and methylprednisolone acetate in hand joints were compared in a randomly selected double-blind trial. The patients included 21 with rheumatoid arthritis and 3 with psoriatic arthritis, and the design was an intrapatient comparison. No difference between joints treated…

Ranitidine hydrochloride (an H2-receptor-blocking drug which does not contain the imidazole nucleus of histamine) powerfully inhibited nocturnal and pentagastrin-stimulated gastric secretion in fifteen patients with duodenal ulceration. The drug is satisfactorily absorbed and therefore warrants clinical trial.

The bioavailabilities of two tablet brands carbamazepine (CBZ) (Tegretol, A; Neurotol, B) were compared with two new experimental preparations (C,D). Formulation A showed a more sustained release nature than did the other formulations. The AUCs0 leads to infinity gave no significant differences between treatment A and…

The authors report the multi-institutional evaluation of a radioassay for serum folate utilizing a gamma-labeled folate analog (75Se-pteroyl-L-methylselenocysteine). The assay is run as a one-step simultaneous addition at ambient temperature and is completed within 45 minutes. The assay data were reproducible within fo…

In a double-blind trial renal allograft recipients were treated with fibroblast interferon preparations for 3 months in an attempt to prevent viral infections. Interferon therapy did not reduce the overall incidence of viral infections. No adverse effects were noted on liver function, platelet counts, or leucocyte coun…

In a double-blind double-placebo crossover study naproxen (500-750 mg daily) was found to be equivalent to phenylbutazone (400-600 mg daily) in the control of disease activity in 20 patients suffering from ankylosing spondylitis during a two times 5-week trial period. No serious side effects were observed during the tr…

A 1% clotrimazole solution was used as an antifungal for Tinea versicolor, Cutaneous Candidiasis and Dermatophytosis. All studies were double-blind and controlled, active vs vehicle. The final evaluation was made at a two-week follow-up after the treatment was stopped, which for most of the clinical conditions studied,…

In a double-blind trial, in a total of 45 patients, sulfentanil was compared with fentanyl and morphine in equipotent doses, as a narcotic supplement to anesthesia. Initially, morphine was shown to have a significantly longer duration of effect than fentanyl and sulfentanil, which for the first 3 doses had similar dura…

A double blind comparison of meglumine iodamide and Renografin-60 in bolus intravenous pyelography, using 50 ml of contrast or less, was conducted in 78 patients. Meglumine iodamide produced more dense opacifications, but it also produced a greater number of laboratory abnormalities. All were transient and mild. No ser…

The present report deals with a double-blind study comparing the new butyrophenone derivative, bromperidol, with haloperidol as the reference substance. Both substances were found to be highly effective in the treatment of psychotic syndromes belonging predominantly to the schizophrenia group. Certain clues, including…

As part of a clinical trial among schoolchildren in a suburban community just outside Oslo, dental preventive behavior was studied by means of mailed questionnaires. In all, 340 mothers, i.e. 95% of the sample, filled out and returned the forms. The results indicate a distinct and improving preventive attitude in the t…

In a double-blind study in six subjects propranolol significantly reduced the respiratory sensitivity to carbon dioxide rebreathing. This effect seems to have been due to beta-adrenergic blockade, since it was not seen with D-propranolol. In two subjects increasing doses of propranolol caused progressive reductions in…

Gastrointestinal blood loss provoked by short-term and long-term therapy with aspirin and ibuprofen was compared in patients with rheumatoid arthritis. Blood loss was assessed by isotope counting of four-day stool collections after infusion of 51Cr-labeled autologous erythrocytes. After two weeks on drug or after one y…

Nine patients on maintenance haemodialysis with frequent muscle cramps were given 320 mg quinine sulphate or placebo (in an identical gelatin capsule) at the beginning of each dialysis for a period of 12 weeks. The frequency of cramps was significantly reduced during dialysis in patients receiving quinine sulphate. Non…