11,352,860 papers found

This study's objective was to elucidate the molecular mechanism of hemp seeds against osteoporosis using a network pharmacology approach. The methodology entailed the retrieval of active components and targets of hemp seeds from the TCMSP database, as well as OP-related targets from GeneCards, TTD, Drugbank, and OMIM d…

Attention Deficit/Hyperactivity Disorder (ADHD) is associated with impairments in social cognition and theory of mind (ToM), potentially mediated by alterations in dopaminergic and oxytocinergic pathways. This pilot, proof-of-concept, randomized controlled trial examined the effects of intranasal oxytocin (IN-OT) on To…

BACKGROUND: This study's goal was to assess the safety of intravenous (IV) olanzapine for general hospital inpatients. METHODS: Data were collected through retrospective chart review for any patient who received at least one dose of intravenous olanzapine between January 2013 and December 2022. Primary outcomes were v…

UNLABELLED: Gaucher disease (GD), the most common lysosomal disorder, is caused by a deficiency of the enzyme glucocerebrosidase (GCase). Accumulation of the substrate, glycosylceramide (Gb-1), and its lysosomal derivative, glucosylsphingosine, Lyso-Gb1, are associated with immune-mediated inflammation. Patients with G…

BACKGROUND: Proximal humerus fractures (PHFs) are a prevalent orthopedic injury and often require surgical intervention. These surgeries frequently involve resident participation as part of their training, but the impact of this involvement on surgical outcomes remains unclear. This study evaluates the effect of reside…

INTRODUCTION: Although the potential utility of large language models (LLMs) in medicine and healthcare is substantial, no assessment has been made to date of how GPs want LLMs to be applied in primary care, or of which issues GPs are most concerned about regarding the implementation of LLMs into their clinical practic…

PURPOSE: The study's aim was to characterize the variations in spinopelvic alignment among an asymptomatic population and to establish a classification system for this alignment. Additionally, it sought to formulate predictive formulas for lumbar lordosis (LL) based on pelvic incidence (PI) to enhance the accuracy of s…

INTRODUCTION: During centrifuge-simulated suborbital spaceplane flights, launch and re-entry frequently cause visual symptoms, and G-induced loss of consciousness can occur. G-related effects may be more prominent during re-entry from microgravity on actual flights. A modified anti-G maneuver that does not involve a br…

BACKGROUND Amyotrophic lateral sclerosis (ALS) is a motor neuron disease that leads to rapid degeneration of nerves in the brain and spinal cord, with eventual loss of voluntary movements, including breathing. This retrospective study of medical record data from 105 US veterans diagnosed with ALS at the Oklahoma City V…

Due to genetic, hormonal, and environmental factors, alongside increased life expectancy, breast cancer (BC) survivors have an increased risk of developing a second primary malignancy. Therefore, regular screening for other types of cancer is of utmost importance for their comprehensive care. This cross-sectional study…

Caregivers of children with medical complexity face daily tasks comparable to pediatric critical care nursing with multiple stressors. This may result in emotional and spiritual distress. Caregivers may also rely on their religion and spirituality to cope. Chaplains have the potential to support caregivers in this sett…

AIMS: To investigate the relationships among communication competence, professional autonomy and clinical reasoning and to identify the factors that influence clinical reasoning competence in oncology nurses. DESIGN: Cross-sectional descriptive design. METHODS: Participants included 147 oncology nurses with more than…

This double-blind, randomised clinical trial aimed to find out whether there is a difference in the prevalence of neurosensory disturbance (NSD) between patients who received 2% lidocaine and those who received 4% articaine during inferior alveolar nerve blocks (IANBs). Patients who underwent third molar extraction wer…

In October 2023, Israel sustained a massive terror attack, with 1,300 people murdered, over 240 kidnapped, and millions exposed to the horrors. This study's aim is to examine the profile of patients arriving to the emergency department (ED) for psychiatric services during the month following the attack, compared to a s…

BACKGROUND: Autoimmune diseases often coexist; however, the concomitant occurrence of systemic lupus erythematosus (SLE) and primary biliary cirrhosis (PBC) is rare. Therefore, this study aims to provide a comprehensive summary of evidence regarding the co-occurrence of SLE and PBC. METHODS: PubMed, Web of Science, Sc…

BACKGROUND: There is a scarcity of scientific data regarding the correlation between alignment techniques during total knee arthroplasty (TKA) and blood loss as well as transfusion rates. This study's hypothesis posited that intramedullary-aligned (IM) TKA exhibits higher blood loss and transfusion rates when contraste…

IntroductionThe National Oncology Institute of Morocco's (NIO) shift to an automated cytotoxic drug preparation system (PHARMODUCT®) has prompted an evaluation of its economic and clinical impacts compared to traditional manual methods.MethodsA retrospective cost-benefit analysis over six months, extrapolated to a…

Despite numerous theoretical and empirical studies exploring the spatial needs of road users, a significant gap remains in validating these findings with extensive real-world data sets. This study presents the idea of "safe spaces," outlining the buffer zones that both walkers and e-bicyclists maintain when crossing st…

BACKGROUND: Colon cancer is an important cause of mortality related to cancer. During the COVID-19 pandemic, an important reallotment of assistance resources was necessary to tackle the crisis, directly impacting medical practice all over the globe. OBJECTIVE: To assess the impact of the Sars-Cov-2 pandemic on the tim…

INTRODUCTION/OBJECTIVES: Psoriatic arthritis (PsA) is a chronic multisystem osteoarticular disease that requires specialized care. Most Brazilians depend on the public healthcare provided by the Unified Health System (Sistema Único de Saúde, SUS). This study aimed to describe the epidemiological characteristi…