42,213 papers found

INTRODUCTION: Migraine is among the most disabling neurological disorders worldwide and preventive treatment remains a cornerstone for reducing disease burden. Recent advances in mechanism-based therapies have positioned calcitonin gene-related peptide (CGRP) and its main receptor as central targets for migraine prophy…

The intricate crosstalk between probiotics and the host immune system is increasingly recognized as a central determinant of mucosal integrity, resistance to infection, and systemic homeostasis. This narrative review synthesizes current evidence identified through comprehensive searches of major scientific databases, i…

INTRODUCTION: High-throughput screening (HTS) has been central to antibacterial drug discovery for decades, identifying active compounds from large libraries. Advances in screening methodologies and compound availability have extended HTS from large organizations to smaller biotech and academic groups. Despite increase…

Depression is a common and serious concern in cancer patients, significantly impacting quality of life, treatment adherence, and overall prognosis. While traditional antidepressants often take weeks to exert therapeutic effects, ketamine has emerged as a potential alternative due to its rapid antidepressant action. Thi…

Knee osteoarthritis (OA) is a chronic, multifactorial joint disorder involving cartilage degeneration, subchondral bone changes, synovial inflammation, and neuromuscular dysfunction. Exercise is first-line therapy, yet heterogeneity in modalities, dosing, and delivery limits practical guidance. A narrative review was c…

INTRODUCTION: Thoracic and lumbar vertebral fractures are rare causes of hemothorax, and data on the clinical characteristics of patients with massive hemothorax caused by blunt vertebral fractures are limited. METHODS: We conducted a literature search using PubMed, Embase, CENTRAL, Web of Science, and Google Scholar…

BACKGROUND: Ghrelin, a brain-intestinal hormone, is a growth hormone (GH) secretagogue. Because it regulates appetite and is secreted most prominently before meals, it is often described as a "hunger hormone". It consists of 28 amino acids. Given the connection between nutritional status and energy metabolism, it sugge…

: Postoperative thrombocytopenia is a frequent finding after cardiac surgery, affecting approximately 10-40% of patients. The early decline in platelet count, typically observed within the first 48-72 h, is usually explained by hemodilution, perioperative platelet consumption, and the inflammatory or mechanical impact…

This review synthesizes in silico evidence on the toxicological effects of microplastics (MPs) and nanoplastics (NPs) in zebrafish (). With the increasing prevalence of these pollutants in aquatic ecosystems, evaluating their molecular impacts is essential for risk assessment. We systematically mined toxicogenomic stud…

Chronic wounds are a growing healthcare challenge, with infections being major complications that delay healing. Biofilms are structured microbial communities encased in extracellular polymeric substances. Biofilms confer antimicrobial resistance, promote inflammation, and protect pathogens from host defenses. These me…

Cranial neuropathy is a commonly encountered condition with various underlying etiologies. While carotid artery dissection (CAD) is a well-recognized cause of ischemic stroke, CAD-related cranial neuropathy is rare and poorly characterized. We have conducted a comprehensive review of the published literature to better…

This systematic review aimed to evaluate the association betweenin the oral cavity as an extragastric reservoir and oral diseases in patients with or without gastritis. Following the PRISMA guidelines, a comprehensive search was conducted on the PubMed, Scopus, Cochrane Central, and Embase databases (2010-2025) using M…

PURPOSE: This meta-review of qualitative studies aims to explore the experiences and needs of family members following perinatal infant deaths. DESIGN: A qualitative meta-synthesis was conducted. DATA SOURCES: Four databases, PubMed, CINAHL, EMBASE, and Web of Science, were searched from inception through November 20…

INTRODUCTION: The purpose of this systematic review is to examine the effects of virtual reality training (VRT) on the muscle strength of the elderly. METHODS: Primary sources were obtained from 4 databases including PubMed, SCOPUS, CENTRAL, and Web of Science. The search period covered years from inception to Februar…

The scope of this article is to identify adolescents' social representations of the body and how the issue of black bodies has been discussed. This is a systematic review whose searches took place in August 2023 in PubMed/MEDLINE, SciELO, Scopus, Web of Science, PsycInfo, PePSIC, BVS, and in the BDTD and OATD portals.…

In cases of severe oligospermia and non-obstructive azoospermia, few spermatozoa with appropriate motility and viability are detected in epididymal and testicular samples. Sperm cryopreservation is performed to avoid multiple testis biopsies and to maintain samples. Consequently, various sperm retrieval methods are emp…

BACKGROUND: Numerous investigations have explored variations in vertical air pollutant concentrations, yielding diverse findings. So, we have conducted this systematic review to gain a more comprehensive understanding of the vertical distribution of air pollutant concentrations (PM, PM, NO, and NO) and the influencing…

BACKGROUND: Hairy cell leukemia (HCL) is a rare indolent B-cell lymphoid malignancy. The majority of patients are asymptomatic and HCL is usually diagnosed incidentally during a routine blood cell count. In symptomatic patients, typical symptoms are related to pancytopenia and splenomegaly. In this review, we present r…

The present systematic review and meta-analysis aimed to generate high-quality evidence on the association between preterm delivery (PTD) and subsequent risk of renal disease in the mother. A literature search was conducted on PubMed, Embase, CENTRAL and Scopus until the 15th of May 2023 for studies reporting an adjust…

Endometriosis is a gynecologic condition often described as the "chameleon of gynecology" because of its elusive symptoms. The World Health Organization acknowledges its severe impact on quality of life due to pain, fatigue, depression, and infertility. There is limited literature on the prevalence of endometriosis, kn…