376,071 papers found

An overview is presented of 23 trials of adjuvant chemotherapy in squamous cell carcinoma of the head and neck. These were reviewed from the point of view of design of the trial, analysis of survival, response rates, meta-analysis, site of failure, toxicity and cost. The minimal increase in survival that could be detec…

BackgroundDespite advances in migraine management, some patients fail to respond to preventive treatments for migraine. We aimed to assess the comparative effects of available pharmacological prophylaxis in adults with a treatment failure history.MethodsWe searched Medline, Embase, Cochrane Central, PsycINFO, Web of Sc…

BACKGROUND: Antiangiogenic combination therapy-antiangiogenic agents combined with immune checkpoint inhibitors and/or chemotherapy-has become an important treatment strategy for advanced driver-negative non-small cell lung cancer (NSCLC). We conducted a network meta-analysis to compare efficacy and safety and identify…

BACKGROUND: Preterm birth is a global health problem associated with an increased risk of neurodevelopmental and physical growth impairment. Early interventions aim to improve cognitive, motor, length, or weight level in preterm infants, but there is wide variation in the frequency, duration, and follow-up of intervent…

The global demand for plant-based milk alternatives is rising, but their health effects compared with cow milk remain uncertain. Therefore, we conducted a systematic review and network meta-analysis (NMA) to compare different plant-based drinks with each other and with cow's milk on cardiometabolic outcomes. A systemat…

OBJECTIVE: Immunotherapy has emerged as a therapeutic alternative to chemotherapy (CT) for perioperative treatment of resectable non-small cell lung cancer (NSCLC). The objective is to perform a network meta-analysis comparing the perioperative efficacy of immunotherapies in resectable NSCLC taking into account tumor e…

Inflation in genome-wide association studies (GWAS) summary statistics represents a major challenge, for which correction methods have been developed. These include the genomic control (GC) method, which uses the λ-value to correct summary statistics, and the linkage disequilibrium score regression (LDSR) method,…

BACKGROUND: The integration of immunotherapy with neoadjuvant therapy for proficient mismatch repair (pMMR) locally advanced rectal cancer (LARC) is a promising strategy. However, the optimal treatment platform, a short-course radiotherapy (SCRT)-based regimen or a long-course chemoradiotherapy (LCRT)-based regimen, re…

BACKGROUND: Perinatal depression and anxiety adversely affect maternal well-being. Although exercise is a promising strategy to improve mental health, the optimal prescription remains uncertain. OBJECTIVES: This study compares the effectiveness of various exercise forms in alleviating depression and anxiety symptoms i…

OBJECTIVE: This study compares short-term effects of thermal ablation techniques, alone or with medications, on dysmenorrhea, menstrual volume, uterine size, and lesion size post-medication cessation. METHODS: Searches were conducted on PubMed, Embase, Cochrane Library, Web of Science, CNKI, WanFang, VIP, CBM, Clinica…

PURPOSE: This study compares the effects of different exercise modalities on inflammatory mediators in breast cancer survivors, evaluating aerobic exercise (AE), resistance training (RT), combined exercise (CE), and low-intensity exercise (LA) on biomarkers to inform personalized exercise prescriptions. METHODS: A sys…

BACKGROUND: Peripheral vascular disease (PVD) causes significant pain and disability in patients. Current conservative treatment for PVD is often limited to physical exercise. However, several recent studies have investigated the effects of physical therapy modalities in patients with PVD. OBJECTIVE: This systematic r…

BACKGROUND AND AIMS: Accurate polyp measurement is vital for colorectal cancer treatment and surveillance. Traditional methods are often unreliable. The FDA-approved Virtual Scale Endoscopy (VSE) provides real-time, laser-calibrated overlays to improve size measurements. This meta-analysis evaluated the diagnostic accu…

OBJECTIVE: Gastrointestinal adverse effects are the most commonly reported adverse effects associated with the use of antidepressants. While existing studies on the gastrointestinal effects of antidepressant medications offer valuable insights, there are still opportunities to enhance the evidence base. METHODS: We in…

OBJECTIVE: To compare the efficacy and safety of lisdexamfetamine, topiramate, and naltrexone/bupropion for treating binge eating disorder (BED) using network meta-analysis. METHOD: We systematically searched PubMed, Scopus, ClinicalTrials.gov, and Cochrane Central up to February 2025 for randomized controlled trials…

BACKGROUND: The combination of neuromodulation interventions with robot-assisted gait training (RAGT) for enhancing lower limb motor function recovery in stroke patients remains contentious. OBJECTIVE: This study aims to investigate the effects of neuromodulation combined with RAGT on patients with lower limb motor dy…

PURPOSE: This systematic review aimed to evaluate the effect of the abutment material on peri-implant soft tissue health and stability. STUDY SELECTION: An electronic and hand search was conducted until February 2022. Only prospective randomized trials (RCTs) and controlled clinical trials (CCTs) comparing titanium ab…

INTRODUCTION: The morbidity related to long-term steroid therapy has led to continued interest in withdrawal of steroids from immunosuppressant regimens after renal transplantation. A number of recent trials have provided long-term information regarding the risks and benefits of steroid avoidance or withdrawal (SAW).…

The review aimed at quantifying the evidence of performance effects resulting from occupational exposure to manganese. Epidemiological studies published between 1987 and 2008 were analyzed. The approach was based on the meta-analytical method of effect size estimates and sought to contribute to the following issues: (1…

BACKGROUND: Genome-wide association studies hold substantial promise for identifying common genetic variants that regulate susceptibility to complex diseases. However, for the detection of small genetic effects, single studies may be underpowered. Power may be improved by combining genome-wide datasets with meta-analyt…